Uniprot accession / id : Q64267  OR   Uniprot accession / id : P23025  OR   Uniprot accession / id : F2Z2T2
 
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (3)
Electron Microscopy
(6)
Solution NMR
(3)
X-ray diffraction
(2)
 
Authors  (59)
Yang W
(6)
Chen X
(4)
Cui Y
(4)
Golebiowski FM
(4)
Hanaoka F
(4)
Kim J
(4)
Li CL
(4)
Sugasawa K
(4)
Wang H
(4)
Jiang YL
(2)
Lian FM
(2)
Qian C
(2)
Yang X
(2)
Barnett JT
(1)
Buchko GW
(1)
Chernev A
(1)
Cramer P
(1)
Daughdrill GW
(1)
Dienemann C
(1)
Ellenberger T
(1)
Gochin M
(1)
Ikegami T
(1)
Isern NG
(1)
Ivanov D
(1)
Kad NM
(1)
Kennedy MA
(1)
Kisker C
(1)
Kodo N
(1)
Koelmel W
(1)
Kokic G
(1)
Kuper J
(1)
Kuraoka I
(1)
Kyogoku Y
(1)
Li C
(1)
Lingbeck J
(1)
Lingbeck JM
(1)
Lowry DF
(1)
Morikawa K
(1)
Oberman R
(1)
Orelli B
(1)
Rao B K
(1)
Rao S
(1)
Saijo M
(1)
Scharer OD
(1)
Schärer OD
(1)
Shirakawa M
(1)
Shoshani I
(1)
Spicer LD
(1)
Staresincic L
(1)
Tanaka K
(1)
Taylor J
(1)
Taylor JS
(1)
Tegunov D
(1)
Tsodikov OV
(1)
Urlaub H
(1)
Wagner G
(1)
Wold MS
(1)
Yang F
(1)
de Lorimier R
(1)
 
Homo / hetero assembly  (2)
hetero
(8)
homo
(3)
 
Assembly composition  (3)
DNA/protein complex
(7)
protein structure
(3)
protein/protein complex
(1)
 
Assembly polymer count  (7)
monomer
(3)
dodecamer
(2)
undecamer
(2)
decamer
(1)
dimer
(1)
nonamer
(1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(1)
3.0 - 3.5
(3)
3.5 - 4
(3)
 
Release year distribution
1995 - 2000
(2)
2005 - 2010
(1)
2015 - 2020
(3)
2020 - 2025
(6)
 
Journal  (8)
Nature
(4)
Biochem Biophys Res Commun
(1)
Biochemistry
(1)
EMBO J
(1)
Int J Biol Macromol
(1)
Nat Commun
(1)
Nat Struct Biol
(1)
Nucleic Acids Res
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(11)
 
Organism name  (1)
Homo sapiens
(11)
 
Molecule name  (2)
DNA repair protein complementing XP-A cells
(11)
Xeroderma pigmentosum group A-complementing protein
(11)
 
Molecule type  (1)
Protein
(11)
 
Gene names  (2)
XPA
(11)
XPAC
(11)
 
Interacting Molecules  (18)
General transcription and DNA repair factor IIH helicase subunit XPD
(6)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB
(6)
General transcription factor IIH subunit 2
(6)
General transcription factor IIH subunit 3
(6)
General transcription factor IIH subunit 4
(6)
General transcription factor IIH subunit 5
(6)
General transcription factor IIH subunit 1
(5)
DNA repair protein complementing XP-C cells
(4)
DNA
(3)
Centrin-2
(2)
DNA1
(2)
DNA2
(2)
DNA (49-MER)
(1)
DNA (5'-D(P*GP*CP*AP*TP*CP*TP*CP*GP*CP*CP*T)-3')
(1)
DNA (5'-D(P*TP*GP*GP*CP*GP*AP*GP*AP*TP*GP*C)-3')
(1)
DNA (Ap)
(1)
DNA (Cy5)
(1)
DNA excision repair protein ERCC-1
(1)
 
Interacting ligands  (1)
ZN : ZINC ION
(10)
 
Function and Biology
Biological function  (8)
damaged DNA binding
(10)
DNA binding
(5)
metal ion binding
(5)
protein binding
(5)
protein domain specific binding
(5)
protein homodimerization activity
(5)
sequence-specific double-stranded DNA binding
(5)
zinc ion binding
(5)
 
Biological process  (16)
nucleotide-excision repair
(10)
DNA damage response
(5)
DNA repair
(5)
UV protection
(5)
UV-damage excision repair
(5)
base-excision repair
(5)
intrinsic apoptotic signaling pathway in response to DNA damage
(5)
multicellular organism growth
(5)
nucleotide-excision repair involved in interstrand cross-link repair
(5)
nucleotide-excision repair, DNA damage recognition
(5)
positive regulation of transcription initiation by RNA polymerase II
(5)
protein localization to nucleus
(5)
regulation of autophagy
(5)
response to UV
(5)
response to oxidative stress
(5)
response to toxic substance
(5)
 
Biological cell component  (6)
DNA replication factor A complex
(5)
cytosol
(5)
nuclear body
(5)
nucleoplasm
(5)
nucleotide-excision repair factor 1 complex
(5)
nucleus
(5)
 
Sequence and Structure classification
SCOP fold  (2)
Glucocorticoid receptor-like (DNA-binding domain)
(2)
Putative DNA-binding domain
(2)
 
SCOP family  (2)
DNA repair factor XPA DNA- and RPA-binding domain, C-terminal subdomain
(2)
DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain
(2)
 
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (1)
Nucleotide Excision Repair Protein XPA (XPA-MBD); B Chain A
(2)
 
Pfam accession / name  (2)
PF01286 : XPA_N
(10)
PF05181 : XPA_C
(10)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(3)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (1)
SSRF BEAMLINE BL19U1
(2)
 
Synchrotron site  (1)
SSRF
(2)
 
Diffraction detector type  (1)
Pixel
(2)
 
Refinement software  (3)
REFMAC
(2)
PHENIX
(1)
X-PLOR
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(6)
 
EM detector name  (2)
GATAN K3 (6k x 4k)
(4)
GATAN K2 SUMMIT (4k x 4k)
(2)
 
NMR
NMR software packages  (2)
X-PLOR
(2)
Xplor-NIH
(1)
 
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(3)
600.0 - 700
(2)
700.0 - 800
(3)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 11
Entries 1 to 10 of 11
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XPC release from Core7-XPA-DNA (AP)
Kim J, Yang W
Nature (2023) [PMID: 37076618  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-230655 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 3 more)
Electron Microscopy
3.6Å resolution
Released: 19 Apr 2023
Model geometry
Fit model/data
Data not analysed
8eby
8eby
8eby
XPC release from Core7-XPA-DNA (Cy5)
Kim J, Yang W
Nature (2023) [PMID: 37076618  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-230651 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 3 more)
Electron Microscopy
3.3Å resolution
Released: 19 Apr 2023
Model geometry
Fit model/data
Data not analysed
8ebu
8ebu
8ebu
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)
Kim J, Yang W
Nature (2023) [PMID: 37076618  ]
Assembly composition: DNA/protein complex
Bound ligands: CA    ZN    CA    ZN   
Modified residues: VM6    VM6   
PDBe complex ID: PDB-CPX-270386 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 4 more)
Electron Microscopy
3.9Å resolution
Released: 19 Apr 2023
Model geometry
Fit model/data
Data not analysed
8ebt
8ebt
8ebt
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
Kim J, Yang W
Nature (2023) [PMID: 37076618  ]
Assembly composition: DNA/protein complex
Bound ligands: CA    ZN    CA    ZN   
Modified residues: 3DR    3DR   
PDBe complex ID: PDB-CPX-230654 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 4 more)
Electron Microscopy
3.6Å resolution
Released: 19 Apr 2023
Model geometry
Fit model/data
Data not analysed
8ebx
8ebx
8ebx
Core TFIIH-XPA-DNA complex with modelled p62 subunit
Koelmel W, Kuper J, Kisker C
Nucleic Acids Res (2020) [PMID: 33166411  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-121053 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 2 more)
Electron Microscopy
3.5Å resolution
Released: 28 Jul 2021
Model geometry
Fit model/data
Data not analysed
7ad8
7ad8
7ad8
Crystal structure of the redefined DNA-binding domain of human XPA
Lian FM, Yang X, Yang W, Jiang YL, Qian C
Biochem Biophys Res Commun (2019) [PMID: 31092331  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: DNA repair protein complementing XP-A cells (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149868 (Preferred)   search this ID
PDBe-KB: P23025   
X-ray diffraction
2.06Å resolution
Released: 29 May 2019
Model geometry
Fit model/data
6j44
6j44
6j44
Structure of the core TFIIH-XPA-DNA complex
Kokic G, Chernev A, Tegunov D, Dienemann C, Urlaub H, Cramer P
Nat Commun (2019) [PMID: 31253769  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-120561 (Preferred)   search this ID
PDBe-KB: P23025    P19447    Q13889    Q92759    Q13888    Q6ZYL4    (view 1 more)
Electron Microscopy
3.5Å resolution
Released: 3 Jul 2019
Model geometry
Fit model/data
Data not analysed
6ro4
6ro4
6ro4
SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M
Nat Struct Biol (1998) [PMID: 9699634  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: DNA repair protein complementing XP-A cells (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149868 (Preferred)   search this ID
PDBe-KB: P23025   
Solution NMR
Released: 22 Jul 1999
Model geometry
Fit model/data
Data not analysed
1xpa
1xpa
1xpa
Crystal structure of the DNA-binding domain of human XPA in complex with DNA
Lian FM, Yang X, Jiang YL, Yang F, Li C, Yang W, Qian C
Int J Biol Macromol (2020) [PMID: 31962067  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: DNA repair protein complementing XP-A cells and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-120205 (Preferred)   search this ID
PDBe-KB: P23025   
X-ray diffraction
2.81Å resolution
Released: 26 Feb 2020
Model geometry
Fit model/data
6lae
6lae
6lae
INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIR PROTEIN XPA WITH RPA70 AND DNA: CHEMICAL SHIFT MAPPING AND 15N NMR RELAXATION STUDIES
Buchko GW, Daughdrill GW, de Lorimier R, Rao S, Isern NG, Lingbeck J, Taylor J, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA
Biochemistry (1999) [PMID: 10563794  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: DNA repair protein complementing XP-A cells (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149868 (Preferred)   search this ID
PDBe-KB: P23025   
Solution NMR
Released: 17 Oct 1999
Model geometry
Fit model/data
Data not deposited
1d4u
1d4u
1d4u
Entries 1 to 10 of 11
Entries 1 to 10 of 11