Uniprot accession / id : (Q676U5)
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (2)
X-ray diffraction
(12)
Solution NMR
(1)
 
Authors  (66)
Archna A
(3)
Gong X
(3)
Gong XY
(3)
Metlagel Z
(3)
Otomo C
(3)
Otomo T
(3)
Pan L
(3)
Pan LF
(3)
Scrima A
(3)
Takaesu G
(3)
Wang Y
(3)
Li M
(2)
Tang Y
(2)
Zhang M
(2)
Zhang Y
(2)
Bajagic M
(1)
Bhunia A
(1)
Burmeister M
(1)
Busing P
(1)
Büsing P
(1)
Calligari P
(1)
Choi EJ
(1)
Cui J
(1)
Fujioka Y
(1)
Gatica D
(1)
Han S
(1)
Hong SB
(1)
Jipa A
(1)
Juhasz G
(1)
Karpati M
(1)
Kim B
(1)
Kim JH
(1)
Kim M
(1)
Kim YK
(1)
Klionsky DJ
(1)
Kurata I
(1)
Lee JH
(1)
Lee JK
(1)
Lee KE
(1)
Li JZ
(1)
Liu X
(1)
Matoba K
(1)
Mavioglu RN
(1)
Mohid A
(1)
Mohid SA
(1)
Noda NN
(1)
Ogasawara Y
(1)
Qiu Y
(1)
Reynison J
(1)
Ro SH
(1)
Roh KH
(1)
Sandford E
(1)
Sarojini V
(1)
Schulman BA
(1)
Semple I
(1)
Shibasaki M
(1)
Song HK
(1)
Stella L
(1)
Takats S
(1)
Tolun A
(1)
Varnava KG
(1)
Watanabe T
(1)
Xu J
(1)
Yapici Z
(1)
Zheng Y
(1)
Zhou Y
(1)
 
Homo / hetero assembly  (2)
hetero
(11)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(11)
protein structure
(2)
 
Assembly polymer count  (5)
dimer
(5)
tetramer
(4)
monomer
(2)
hexamer
(1)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(2)
2.0 - 2.5
(1)
2.5 - 3
(6)
3.0 - 3.5
(2)
 
Release year distribution
2010 - 2015
(4)
2015 - 2020
(6)
2020 - 2025
(4)
2025 - 2030
(1)
 
Journal  (10)
Acta Crystallogr F Struct Biol Commun
(2)
Nat Struct Mol Biol
(2)
Sci Adv
(2)
Autophagy
(1)
Bioconjug Chem
(1)
Cells
(1)
Elife
(1)
J Am Chem Soc
(1)
Proc Natl Acad Sci U S A
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (1)
Homo sapiens
(13)
 
Molecule name  (22)
APG16-like 1
(13)
Autophagy-related protein 16-1
(13)
APG5-like
(8)
Apoptosis-specific protein
(8)
Autophagy protein 5
(8)
APG12-like
(3)
Autophagy-related protein 12
(3)
Ubiquitin-like protein ATG12
(3)
WD repeat domain phosphoinositide-interacting protein 2
(2)
WIPI-2
(2)
WIPI49-like protein 2
(2)
APG3-like
(1)
Autophagy-related protein 3
(1)
Protein PC3-96
(1)
Ubiquitin-like-conjugating enzyme ATG3
(1)
WD repeat domain phosphoinositide-interacting protein 3
(1)
WD repeat-containing protein 45-like
(1)
WD repeat-containing protein 45B
(1)
WDR45-like protein
(1)
WIPI-3
(1)
WIPI49-like protein
(1)
hApg3
(1)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (17)
APG16L
(13)
ATG16L1
(13)
UNQ9393/PRO34307
(13)
APG5L
(8)
ASP
(8)
ATG5
(8)
APG12
(3)
APG12L
(3)
ATG12
(3)
CGI-50
(2)
WIPI2
(2)
APG3
(1)
APG3L
(1)
ATG3
(1)
WDR45B
(1)
WDR45L
(1)
WIPI3
(1)
 
Interacting Molecules  (6)
Autophagy-related protein 16-1
(11)
Autophagy protein 5
(8)
Ubiquitin-like protein ATG12
(3)
WD repeat domain phosphoinositide-interacting protein 2
(2)
Ubiquitin-like-conjugating enzyme ATG3
(1)
WD repeat domain phosphoinositide-interacting protein 3
(1)
 
Interacting ligands  (3)
NA : SODIUM ION
(3)
BU3 : (R,R)-2,3-BUTANEDIOL
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (2)
Atg8-family ligase activity
(8)
protein binding
(8)
 
Biological process  (52)
autophagosome assembly
(9)
aggrephagy
(8)
antigen processing and presentation of endogenous antigen
(8)
apoptotic process
(8)
autophagy
(8)
axonal transport
(8)
blood vessel remodeling
(8)
cardiac muscle cell apoptotic process
(8)
cellular response to nitrogen starvation
(8)
cellular response to nitrosative stress
(8)
cellular response to starvation
(8)
chaperone-mediated autophagy
(8)
chromatin organization
(8)
defense response to virus
(8)
establishment of localization in cell
(8)
heart contraction
(8)
immune system process
(8)
innate immune response
(8)
macroautophagy
(8)
mitophagy
(8)
mucus secretion
(8)
negative regulation of apoptotic process
(8)
negative regulation of autophagic cell death
(8)
negative regulation of cardiac muscle cell apoptotic process
(8)
negative regulation of defense response to virus
(8)
negative regulation of innate immune response
(8)
negative regulation of phagocytosis
(8)
negative regulation of protein ubiquitination
(8)
negative regulation of type I interferon production
(8)
negative stranded viral RNA replication
(8)
negative thymic T cell selection
(8)
otolith development
(8)
piecemeal microautophagy of the nucleus
(8)
positive regulation of autophagy
(8)
positive regulation of mucus secretion
(8)
positive regulation of stress granule assembly
(8)
positive regulation of viral translation
(8)
post-translational protein modification
(8)
postsynaptic modulation of chemical synaptic transmission
(8)
protein ubiquitination
(8)
regulation of autophagosome maturation
(8)
regulation of cilium assembly
(8)
regulation of cytokine production involved in immune response
(8)
regulation of postsynaptic membrane neurotransmitter receptor levels
(8)
regulation of reactive oxygen species metabolic process
(8)
regulation of release of sequestered calcium ion into cytosol
(8)
response to fluoride
(8)
response to fungus
(8)
response to iron(II) ion
(8)
response to xenobiotic stimulus
(8)
vasodilation
(8)
ventricular cardiac muscle cell development
(8)
 
Biological cell component  (17)
Atg12-Atg5-Atg16 complex
(8)
Schaffer collateral - CA1 synapse
(8)
autophagosome
(8)
axon
(8)
axoneme
(8)
cytoplasm
(8)
cytosol
(8)
glutamatergic synapse
(8)
membrane
(8)
mitochondria-associated endoplasmic reticulum membrane contact site
(8)
phagocytic vesicle membrane
(8)
phagophore
(8)
phagophore assembly site membrane
(8)
postsynapse
(8)
protein-containing complex
(8)
synapse
(8)
transferase complex
(8)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
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Crystal Structure of Human ATG12~ATG5-ATG16N in complex with a fragment of ATG3
Metlagel Z, Otomo C, Takaesu G, Otomo T
Proc Natl Acad Sci U S A (2013) [PMID: 24191030  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NA    SO4    NA   
Assembly name: ATG5-ATG12 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-131766 (Preferred)   search this ID
PDBe-KB: Q9NT62    Q9H1Y0    O94817    Q676U5   
X-ray diffraction
2.195Å resolution
Released: 6 Nov 2013
Model geometry
Fit model/data
4naw
4naw
4naw
Structure of human ATG5-ATG16L1(ATG5BD) complex (C2)
Archna A, Scrima A
Acta Crystallogr F Struct Biol Commun (2017) [PMID: 28994404  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy protein 5 and Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179296 (Preferred)   search this ID
PDBe-KB: Q9H1Y0    Q676U5   
X-ray diffraction
3.1Å resolution
Released: 11 Oct 2017
Model geometry
Fit model/data
5npw
5npw
5npw
Crystal structure of WIPI3 in complex with ATG16L1
Gong XY, Pan LF
Cells (2024)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy-related protein 16-1 and WD repeat domain phosphoinositide-interacting protein 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283544 (Preferred)   search this ID
PDBe-KB: Q5MNZ6    Q676U5   
X-ray diffraction
2.77Å resolution
Released: 1 Jan 2025
Model geometry
Fit model/data
8zqg
8zqg
8zqg
Crystal structure of WIPI2b in complex with the second site of ATG16L1
Gong XY, Pan LF
Sci Adv (2023) [PMID: 36857448  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy-related protein 16-1 and WD repeat domain phosphoinositide-interacting protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-227921 (Preferred)   search this ID
PDBe-KB: Q9Y4P8    Q9Y4P8    Q676U5   
X-ray diffraction
1.76Å resolution
Released: 8 Mar 2023
Model geometry
Fit model/data
7xfr
7xfr
7xfr
Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1
Otomo C, Metlagel Z, Takaesu G, Otomo T
Nat Struct Mol Biol (2013) [PMID: 23202584  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NA    NA   
PDBe complex ID: PDB-CPX-131767 (Preferred)   search this ID
PDBe-KB: O94817    Q9H1Y0    Q676U5   
X-ray diffraction
2.7Å resolution
Released: 5 Dec 2012
Model geometry
Fit model/data
4gdk
4gdk
4gdk
Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1
Otomo C, Metlagel Z, Takaesu G, Otomo T
Nat Struct Mol Biol (2013) [PMID: 23202584  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NA    NA   
Assembly name: ATG5-ATG12 complex and Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-131765 (Preferred)   search this ID
PDBe-KB: O94817    Q9H1Y0    Q676U5   
X-ray diffraction
2.875Å resolution
Released: 5 Dec 2012
Model geometry
Fit model/data
4gdl
4gdl
4gdl
Crystal structure of human ATG5-ATG16N69
Kim JH, Hong SB, Song HK
Autophagy (2015) [PMID: 25484072  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy protein 5 and Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179296 (Preferred)   search this ID
PDBe-KB: Q9H1Y0    Q676U5   
X-ray diffraction
2.697Å resolution
Released: 11 Mar 2015
Model geometry
Fit model/data
4tq0
4tq0
4tq0
Structure of human ATG5-ATG16L1(ATG5BD) complex (I4)
Archna A, Scrima A
Acta Crystallogr F Struct Biol Commun (2017) [PMID: 28994404  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy protein 5 and Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179296 (Preferred)   search this ID
PDBe-KB: Q9H1Y0    Q676U5   
X-ray diffraction
3.1Å resolution
Released: 11 Oct 2017
Model geometry
Fit model/data
5npv
5npv
5npv
Structure of human ATG5 E122D-ATG16L1 complex at 3.0 Angstroms
Qiu Y, Schulman BA
Elife (2016) [PMID: 26812546  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Autophagy protein 5 and Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179298 (Preferred)   search this ID
PDBe-KB: Q9H1Y0    Q676U5   
X-ray diffraction
3Å resolution
Released: 3 Feb 2016
Model geometry
Fit model/data
5d7g
5d7g
5d7g
Solution NMR structure of K30 peptide in 10 mM dioctanoyl phosphatidylglycerol (D8PG)
Bhunia A, Mohid A, Stella L, Calligari P
Bioconjug Chem (2019) [PMID: 31145591  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Autophagy-related protein 16-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179295 (Preferred)   search this ID
PDBe-KB: Q676U5   
Solution NMR
Released: 12 Jun 2019
Model geometry
Fit model/data
Data not analysed
5zyx
5zyx
5zyx
Entries 1 to 10 of 13
Entries 1 to 10 of 13