Uniprot accession / id : Q6P1D7  OR   Uniprot accession / id : Q8IY92
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (2)
X-ray diffraction
(4)
Solution NMR
(1)
 
Authors  (50)
Lei M
(3)
Wan B
(3)
Wu J
(3)
Arrowsmith CH
(2)
Chen Y
(2)
Liu Y
(2)
Bountra C
(1)
Bradley A
(1)
Bullock A
(1)
Burgess-Brown NA
(1)
Chaikuad A
(1)
Chang S
(1)
Cooper CDO
(1)
Edwards AM
(1)
Fairhead M
(1)
Filippakopoulos P
(1)
Fitzpatrick F
(1)
Gu P
(1)
Horvath K
(1)
Houliston S
(1)
Hozjan V
(1)
Kopec J
(1)
Krojer T
(1)
Lemak A
(1)
Lu J
(1)
Lue NF
(1)
Marsden BD
(1)
Nowak R
(1)
Patel A
(1)
Payliss BJ
(1)
Pike ACW
(1)
Pinkas DM
(1)
Reichheld SE
(1)
Roos AK
(1)
Sanvitale CE
(1)
Sarkar J
(1)
Savitsky P
(1)
Sharpe S
(1)
Sorrell FJ
(1)
Strain-Damerell C
(1)
Tallant C
(1)
Tse YWE
(1)
Wan K
(1)
Wang D
(1)
Wyatt HDM
(1)
Yin J
(1)
Ying Z
(1)
Yu EY
(1)
Yun HY
(1)
von Delft F
(1)
 
Homo / hetero assembly  (2)
homo
(3)
hetero
(2)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(2)
 
Assembly polymer count  (4)
dimer
(2)
hexamer
(1)
monomer
(1)
tetramer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(2)
 
Release year distribution
2010 - 2015
(2)
2015 - 2020
(1)
2020 - 2025
(2)
 
Journal  (2)
To be published
(3)
Cell Rep
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (1)
Homo sapiens
(5)
 
Molecule name  (2)
BTB/POZ domain-containing protein 12
(5)
Structure-specific endonuclease subunit SLX4
(5)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (4)
BTBD12
(5)
KIAA1784
(5)
KIAA1987
(5)
SLX4
(5)
 
Interacting Molecules  (2)
Crossover junction endonuclease MUS81
(1)
Telomeric repeat-binding factor 2
(1)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (1)
Potassium Channel Kv1.1; Chain A
(2)
 
Pfam accession / name  (1)
PF00651 : BTB
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
APS BEAMLINE 21-ID-D
(2)
APS BEAMLINE 21-ID-F
(1)
DIAMOND BEAMLINE I03
(1)
 
Synchrotron site  (2)
APS
(3)
Diamond
(1)
 
Diffraction detector type  (2)
CCD
(3)
Pixel
(1)
 
Refinement software  (2)
PHENIX
(2)
REFMAC
(2)
 
NMR
NMR software packages  (6)
CNS
(1)
CYANA
(1)
CcpNmr Analysis
(1)
FMCGUI
(1)
NMRFAM-SPARKY
(1)
NMRPipe
(1)
 
NMR Field Strength
600.0 - 700
(1)
700.0 - 800
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Crystal Structure of Human SLX4 and MUS81
Wan B, Wu J, Lei M
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GLY    GLY   
Assembly name: Structure-specific endonuclease subunit SLX4 and Crossover junction endonuclease MUS81 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184926 (Preferred)   search this ID
PDBe-KB: Q8IY92    Q96NY9   
X-ray diffraction
1.8Å resolution
Released: 7 Apr 2021
Model geometry
Fit model/data
7bu5
7bu5
7bu5
NMR solution structure of the phosphorylated MUS81-binding region from human SLX4
Payliss BJ, Reichheld SE, Lemak A, Arrowsmith CH, Sharpe S, Wyatt HDM
Cell Rep (2022) [PMID: 36288699  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: TPO    TPO   
Assembly name: Structure-specific endonuclease subunit SLX4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184925 (Preferred)   search this ID
PDBe-KB: Q8IY92   
Solution NMR
Released: 19 Oct 2022
Model geometry
Fit model/data
Data not analysed
7tuj
7tuj
7tuj
Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2
Wan B, Chen Y, Wu J, Liu Y, Lei M
Cell Rep (2013) [PMID: 24012755  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: SLX4-TERF2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172321 (Preferred)   search this ID
PDBe-KB: Q8IY92    Q15554   
X-ray diffraction
2.05Å resolution
Released: 25 Sep 2013
Model geometry
Fit model/data
4m7c
4m7c
4m7c
Crystal structure of the BTB domain of human SLX4 (BTBD12)
Pinkas DM, Sanvitale CE, Strain-Damerell C, Fairhead M, Wang D, Tallant C, Cooper CDO, Sorrell FJ, Kopec J, Chaikuad A, Fitzpatrick F, Pike ACW, Hozjan V, Ying Z, Roos AK, Savitsky P, Bradley A, Nowak R, Filippakopoulos P, Krojer T, Burgess-Brown NA, Marsden BD, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Structure-specific endonuclease subunit SLX4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184928 (Preferred)   search this ID
PDBe-KB: Q8IY92   
X-ray diffraction
1.86Å resolution
Released: 1 Oct 2014
Model geometry
Fit model/data
4uyi
4uyi
4uyi
Crystal structure of the BTB domain of SLX4
Wan B, Chen Y, Wu J, Liu Y, Lei M
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Structure-specific endonuclease subunit SLX4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184927 (Preferred)   search this ID
PDBe-KB: Q8IY92   
X-ray diffraction
2.15Å resolution
Released: 4 May 2016
Model geometry
Fit model/data
4zou
4zou
4zou
Entries 1 to 5 of 5
Entries 1 to 5 of 5