Uniprot accession / id : Q6PB93  OR   Uniprot accession / id : Q10471
 
Filter by :
Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (1)
X-ray diffraction
(13)
 
Authors  (74)
Hurtado-Guerrero R
(9)
Lira-Navarrete E
(8)
Clausen H
(7)
Companon I
(7)
Compañón I
(7)
Corzana F
(7)
Iglesias-Fernandez J
(6)
Iglesias-Fernández J
(6)
Kong Y
(6)
Peregrina JM
(6)
Rovira C
(6)
de Las Rivas M
(6)
De Las Rivas M
(4)
Bernado P
(3)
Bernadó P
(3)
Bernardes GJ
(3)
Bernardes GJL
(3)
Bruscolini P
(3)
Lostao A
(3)
Pallares MC
(3)
Pallarés MC
(3)
Pinto BM
(3)
Vocadlo D
(3)
Vocadlo DJ
(3)
Zandberg WF
(3)
delasRivas M
(3)
Agbay AJ
(2)
Bertozzi CR
(2)
Choi J
(2)
Debets MF
(2)
Delso I
(2)
Fernandez D
(2)
Fox DM
(2)
Fritz TA
(2)
Gray MA
(2)
Kohler JJ
(2)
Li Z
(2)
Lin L
(2)
Malaker SA
(2)
Merino P
(2)
Mrksich M
(2)
Pedram K
(2)
Peh J
(2)
Raman J
(2)
Schumann B
(2)
Tabak LA
(2)
Wagner LJS
(2)
Wisnovsky SP
(2)
Agbay A
(1)
Bennett EP
(1)
Coelho H
(1)
De las Rivas M
(1)
Diniz A
(1)
Ghirardello M
(1)
Jimenez-Barbero J
(1)
Jiménez-Barbero J
(1)
Lacetera A
(1)
Li X
(1)
Liu F
(1)
Lu J
(1)
Marcelo F
(1)
Martin-Santamaria S
(1)
Martín-Santamaría S
(1)
Rivas M
(1)
Schjoldager KT
(1)
Tejero T
(1)
Vakhrushev SY
(1)
Wang C
(1)
Wu F
(1)
Xu K
(1)
Xu Z
(1)
Zhang Y
(1)
Zhou Y
(1)
de las Rivas M
(1)
 
Homo / hetero assembly  (2)
hetero
(8)
homo
(5)
 
Assembly composition  (2)
protein/protein complex
(8)
protein structure
(5)
 
Assembly polymer count  (4)
dimer
(9)
monomer
(2)
tetramer
(1)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(4)
2.0 - 2.5
(4)
2.5 - 3
(3)
3.0 - 3.5
(1)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(6)
2015 - 2020
(8)
2020 - 2025
(2)
 
Journal  (5)
Angew Chem Int Ed Engl
(3)
J Biol Chem
(3)
Nat Commun
(3)
Chemistry
(2)
Mol Cell
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (1)
Homo sapiens
(13)
 
Molecule name  (7)
GalNAc-T2
(13)
Polypeptide GalNAc transferase 2
(13)
Polypeptide N-acetylgalactosaminyltransferase 2
(13)
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(13)
Protein-UDP acetylgalactosaminyltransferase 2
(13)
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
(13)
pp-GaNTase 2
(13)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (1)
GALNT2
(13)
 
Interacting Molecules  (5)
Mucin-5AC
(3)
CCN family member 1
(2)
Apomucin
(1)
PEPTIDE
(1)
Submandibular gland mucin
(1)
 
Interacting ligands  (13)
MN : MANGANESE (II) ION
(11)
UDP : URIDINE-5'-DIPHOSPHATE
(8)
EDO : 1,2-ETHANEDIOL
(5)
A2G : 2-acetamido-2-deoxy-alpha-D-galactopyranose
(3)
SO4 : SULFATE ION
(3)
BBK : 2-acetamido-2-deoxy-5-thio-alpha-D-galactopyranose
(2)
UD2 : URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE
(2)
GOL : GLYCEROL
(1)
HWU : (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
(1)
LR7 : [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{R})-3-(hex-5-ynoylamino)-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate
(1)
LU2 : 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
(1)
NGA : 2-acetamido-2-deoxy-beta-D-galactopyranose
(1)
Y6W : [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen (S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]propyl}phosphonate
(1)
 
Function and Biology
EC number / name  (1)
2.4.1.41 : Polypeptide N-acetylgalactosaminyltransferase
(13)
 
Biological function  (7)
carbohydrate binding
(9)
glycosyltransferase activity
(9)
manganese ion binding
(9)
metal ion binding
(9)
polypeptide N-acetylgalactosaminyltransferase activity
(9)
protein binding
(9)
transferase activity
(9)
 
Biological process  (7)
O-glycan processing
(9)
positive regulation of immunoglobulin production
(9)
protein O-linked glycosylation
(9)
protein O-linked glycosylation via serine
(9)
protein O-linked glycosylation via threonine
(9)
protein glycosylation
(9)
protein maturation
(9)
 
Biological cell component  (8)
Golgi apparatus
(9)
Golgi cisterna membrane
(9)
Golgi membrane
(9)
Golgi stack
(9)
endoplasmic reticulum membrane
(9)
extracellular region
(9)
membrane
(9)
perinuclear region of cytoplasm
(9)
 
Sequence and Structure classification
CATH class  (2)
Alpha Beta
(10)
Mainly Beta
(5)
 
CATH topology  (2)
Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
(10)
Trefoil (Acidic Fibroblast Growth Factor, subunit A)
(5)
 
Pfam accession / name  (2)
PF00535 : Glycos_transf_2
(13)
PF00652 : Ricin_B_lectin
(13)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(13)
 
Diffraction radiation source type  (2)
Synchrotron
(12)
Rotating anode
(1)
 
Diffraction source  (9)
ALBA BEAMLINE XALOC
(2)
DIAMOND BEAMLINE I04
(2)
DIAMOND BEAMLINE I04-1
(2)
DIAMOND BEAMLINE I24
(2)
ALS BEAMLINE 5.0.1
(1)
APS BEAMLINE 22-ID
(1)
DIAMOND BEAMLINE I03
(1)
RIGAKU
(1)
SSRL BEAMLINE BL7-1
(1)
 
Synchrotron site  (5)
Diamond
(7)
ALBA
(2)
ALS
(1)
APS
(1)
SSRL
(1)
 
Diffraction detector type  (3)
Pixel
(5)
CCD
(3)
Image plate
(1)
 
Refinement software  (2)
REFMAC
(11)
CNS
(2)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 13
Entries 1 to 10 of 13
 Select all entries on this page
GalNac-T2 soaked with UDP-sugar
Fernandez D, Bertozzi CR, Schumann B, Agbay A
Mol Cell (2020) [PMID: 32325029  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: LR7    MN    MN    LR7   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171230 (Preferred)   search this ID
PDBe-KB: Q10471   
X-ray diffraction
3.05Å resolution
Released: 29 Jan 2020
Model geometry
Fit model/data
6nqt
6nqt
6nqt
Crystal structure of GalNAc-T2 in complex with compound 16d
Ghirardello M, Rivas M, Lacetera A, Delso I, Lira-Navarrete E, Tejero T, Martin-Santamaria S, Hurtado-Guerrero R, Merino P
Chemistry (2016) [PMID: 27071848  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: UDP    GOL    UDP    Y6W    MN    MN    EDO    Y6W   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171230 (Preferred)   search this ID
PDBe-KB: Q10471   
X-ray diffraction
2.07Å resolution
Released: 9 Mar 2016
Model geometry
Fit model/data
5fv9
5fv9
5fv9
Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Hurtado-Guerrero R, De las Rivas M
J Biol Chem (2017) [PMID: 29061849  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: UDP    UDP    MN    MN    EDO    LU2    LU2   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171230 (Preferred)   search this ID
PDBe-KB: Q10471   
X-ray diffraction
2.3Å resolution
Released: 1 Nov 2017
Model geometry
Fit model/data
5ndf
5ndf
5ndf
Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP
Bertozzi CR, Schumann B, Agbay AJ
Mol Cell (2020) [PMID: 32325029  ]
Assembly composition: protein/protein complex
Bound ligands: UDP    UDP    MN    MN   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Apomucin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-280160 (Preferred)   search this ID
PDBe-KB: Q10471    Q62605   
X-ray diffraction
1.8Å resolution
Released: 29 Jan 2020
Model geometry
Fit model/data
6e7i
6e7i
6e7i
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
de las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Jimenez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R
Chemistry (2018) [PMID: 29601100  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: UD2    MN    MN    UD2   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171225 (Preferred)   search this ID
PDBe-KB: Q10471   
X-ray diffraction
2.7Å resolution
Released: 11 Apr 2018
Model geometry
Fit model/data
6egs
6egs
6egs
GalNAc-T2 crystal soaked with UDP-GalNAc, EA2 peptide and manganese
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl (2014) [PMID: 24954443  ]
Assembly composition: protein/protein complex
Bound ligands: UD2    UDP    UDP    MN    NGA    MN    EDO    NGA    UD2   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-164363 (Preferred)   search this ID
PDBe-KB: Q10471   
X-ray diffraction
2.45Å resolution
Released: 28 May 2014
Model geometry
Fit model/data
4d0t
4d0t
4d0t
GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset)
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl (2014) [PMID: 24954443  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: BBK    UDP    UDP    MN    MN    BBK   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and CCN family member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-219592 (Preferred)   search this ID
PDBe-KB: Q10471    Q6FI18   
X-ray diffraction
2.85Å resolution
Released: 28 May 2014
Model geometry
Fit model/data
4d11
4d11
4d11
GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl (2014) [PMID: 24954443  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: BBK    HWU    MN    MN    EDO    BBK    HWU   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and CCN family member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171229 (Preferred)   search this ID
PDBe-KB: Q10471    Q6FI18   
X-ray diffraction
2.2Å resolution
Released: 28 May 2014
Model geometry
Fit model/data
4d0z
4d0z
4d0z
Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13
Lira-Navarrete E, delasRivas M, Companon I, Pallares MC, Kong Y, Iglesias-Fernandez J, Bernardes GJL, Peregrina JM, Rovira C, Bernado P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R
Nat Commun (2015) [PMID: 25939779  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: A2G    SO4    A2G   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Mucin-5AC (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161349 (Preferred)   search this ID
PDBe-KB: Q10471    P98088   
X-ray diffraction
1.48Å resolution
Released: 11 Mar 2015
Model geometry
Fit model/data
5ajo
5ajo
5ajo
Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13
Lira-Navarrete E, delasRivas M, Companon I, Pallares MC, Kong Y, Iglesias-Fernandez J, Bernardes GJL, Peregrina JM, Rovira C, Bernado P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R
Nat Commun (2015) [PMID: 25939779  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: UDP    UDP    A2G    MN    SO4    MN    A2G   
Assembly name: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Mucin-5AC (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161349 (Preferred)   search this ID
PDBe-KB: Q10471    P98088   
X-ray diffraction
1.65Å resolution
Released: 11 Mar 2015
Model geometry
Fit model/data
5ajp
5ajp
5ajp
Entries 1 to 10 of 13
Entries 1 to 10 of 13