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Entry Information
Entry status
(1)
Experimental methods
(1)
X-ray diffraction
(13)
Authors
(74)
Hurtado-Guerrero R
(9)
Lira-Navarrete E
(8)
Clausen H
(7)
Companon I
(7)
Compañón I
(7)
Corzana F
(7)
Iglesias-Fernandez J
(6)
Iglesias-Fernández J
(6)
Kong Y
(6)
Peregrina JM
(6)
Rovira C
(6)
de Las Rivas M
(6)
De Las Rivas M
(4)
Bernado P
(3)
Bernadó P
(3)
Bernardes GJ
(3)
Bernardes GJL
(3)
Bruscolini P
(3)
Lostao A
(3)
Pallares MC
(3)
Pallarés MC
(3)
Pinto BM
(3)
Vocadlo D
(3)
Vocadlo DJ
(3)
Zandberg WF
(3)
delasRivas M
(3)
Agbay AJ
(2)
Bertozzi CR
(2)
Choi J
(2)
Debets MF
(2)
Delso I
(2)
Fernandez D
(2)
Fox DM
(2)
Fritz TA
(2)
Gray MA
(2)
Kohler JJ
(2)
Li Z
(2)
Lin L
(2)
Malaker SA
(2)
Merino P
(2)
Mrksich M
(2)
Pedram K
(2)
Peh J
(2)
Raman J
(2)
Schumann B
(2)
Tabak LA
(2)
Wagner LJS
(2)
Wisnovsky SP
(2)
Agbay A
(1)
Bennett EP
(1)
Coelho H
(1)
De las Rivas M
(1)
Diniz A
(1)
Ghirardello M
(1)
Jimenez-Barbero J
(1)
Jiménez-Barbero J
(1)
Lacetera A
(1)
Li X
(1)
Liu F
(1)
Lu J
(1)
Marcelo F
(1)
Martin-Santamaria S
(1)
Martín-Santamaría S
(1)
Rivas M
(1)
Schjoldager KT
(1)
Tejero T
(1)
Vakhrushev SY
(1)
Wang C
(1)
Wu F
(1)
Xu K
(1)
Xu Z
(1)
Zhang Y
(1)
Zhou Y
(1)
de las Rivas M
(1)
Homo / hetero assembly
(2)
hetero
(8)
homo
(5)
Assembly composition
(2)
protein/protein complex
(8)
protein structure
(5)
Assembly polymer count
(4)
dimer
(9)
monomer
(2)
tetramer
(1)
trimer
(1)
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(4)
2.0 - 2.5
(4)
2.5 - 3
(3)
3.0 - 3.5
(1)
Release year distribution
2005 - 2010
(2)
2010 - 2015
(6)
2015 - 2020
(8)
2020 - 2025
(2)
Journal
(5)
Angew Chem Int Ed Engl
(3)
J Biol Chem
(3)
Nat Commun
(3)
Chemistry
(2)
Mol Cell
(2)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(13)
Organism name
(1)
Homo sapiens
(13)
Molecule name
(7)
GalNAc-T2
(13)
Polypeptide GalNAc transferase 2
(13)
Polypeptide N-acetylgalactosaminyltransferase 2
(13)
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(13)
Protein-UDP acetylgalactosaminyltransferase 2
(13)
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
(13)
pp-GaNTase 2
(13)
Molecule type
(1)
Protein
(13)
Gene names
(1)
GALNT2
(13)
Interacting Molecules
(5)
Mucin-5AC
(3)
CCN family member 1
(2)
Apomucin
(1)
PEPTIDE
(1)
Submandibular gland mucin
(1)
Interacting ligands
(13)
MN : MANGANESE (II) ION
(11)
UDP : URIDINE-5'-DIPHOSPHATE
(8)
EDO : 1,2-ETHANEDIOL
(5)
A2G : 2-acetamido-2-deoxy-alpha-D-galactopyranose
(3)
SO4 : SULFATE ION
(3)
BBK : 2-acetamido-2-deoxy-5-thio-alpha-D-galactopyranose
(2)
UD2 : URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE
(2)
GOL : GLYCEROL
(1)
HWU : (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
(1)
LR7 : [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{R})-3-(hex-5-ynoylamino)-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate
(1)
LU2 : 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
(1)
NGA : 2-acetamido-2-deoxy-beta-D-galactopyranose
(1)
Y6W : [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen (S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]propyl}phosphonate
(1)
Function and Biology
EC number / name
(1)
2.4.1.41 : Polypeptide N-acetylgalactosaminyltransferase
(13)
Biological function
(7)
carbohydrate binding
(9)
glycosyltransferase activity
(9)
manganese ion binding
(9)
metal ion binding
(9)
polypeptide N-acetylgalactosaminyltransferase activity
(9)
protein binding
(9)
transferase activity
(9)
Biological process
(7)
O-glycan processing
(9)
positive regulation of immunoglobulin production
(9)
protein O-linked glycosylation
(9)
protein O-linked glycosylation via serine
(9)
protein O-linked glycosylation via threonine
(9)
protein glycosylation
(9)
protein maturation
(9)
Biological cell component
(8)
Golgi apparatus
(9)
Golgi cisterna membrane
(9)
Golgi membrane
(9)
Golgi stack
(9)
endoplasmic reticulum membrane
(9)
extracellular region
(9)
membrane
(9)
perinuclear region of cytoplasm
(9)
Sequence and Structure classification
CATH class
(2)
Alpha Beta
(10)
Mainly Beta
(5)
CATH topology
(2)
Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
(10)
Trefoil (Acidic Fibroblast Growth Factor, subunit A)
(5)
Pfam accession / name
(2)
PF00535 : Glycos_transf_2
(13)
PF00652 : Ricin_B_lectin
(13)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(13)
Diffraction radiation source type
(2)
Synchrotron
(12)
Rotating anode
(1)
Diffraction source
(9)
ALBA BEAMLINE XALOC
(2)
DIAMOND BEAMLINE I04
(2)
DIAMOND BEAMLINE I04-1
(2)
DIAMOND BEAMLINE I24
(2)
ALS BEAMLINE 5.0.1
(1)
APS BEAMLINE 22-ID
(1)
DIAMOND BEAMLINE I03
(1)
RIGAKU
(1)
SSRL BEAMLINE BL7-1
(1)
Synchrotron site
(5)
Diamond
(7)
ALBA
(2)
ALS
(1)
APS
(1)
SSRL
(1)
Diffraction detector type
(3)
Pixel
(5)
CCD
(3)
Image plate
(1)
Refinement software
(2)
REFMAC
(11)
CNS
(2)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 13
Select all entries on this page
GalNac-T2 soaked with UDP-sugar
Fernandez D, Bertozzi CR, Schumann B, Agbay A
Mol Cell
(2020)
[PMID: 32325029 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171230 (Preferred)
search this ID

Crystal structure of GalNAc-T2 in complex with compound 16d
Ghirardello M, Rivas M, Lacetera A, Delso I, Lira-Navarrete E, Tejero T, Martin-Santamaria S, Hurtado-Guerrero R, Merino P
Chemistry
(2016)
[PMID: 27071848 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171230 (Preferred)
search this ID

Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Hurtado-Guerrero R, De las Rivas M
J Biol Chem
(2017)
[PMID: 29061849 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171230 (Preferred)
search this ID

Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP
Bertozzi CR, Schumann B, Agbay AJ
Mol Cell
(2020)
[PMID: 32325029 ]
Source organisms: Rattus norvegicus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Apomucin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-280160 (Preferred)
search this ID
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
de las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Jimenez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R
Chemistry
(2018)
[PMID: 29601100 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171225 (Preferred)
search this ID

GalNAc-T2 crystal soaked with UDP-GalNAc, EA2 peptide and manganese
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl
(2014)
[PMID: 24954443 ]
Source organisms: synthetic construct , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and peptide
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-164363 (Preferred)
search this ID

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset)
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl
(2014)
[PMID: 24954443 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and CCN family member 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-219592 (Preferred)
search this ID
GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)
Lira-Navarrete E, Iglesias-Fernandez J, Zandberg WF, Companon I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo D, Rovira C, Hurtado-Guerrero R
Angew Chem Int Ed Engl
(2014)
[PMID: 24954443 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and CCN family member 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171229 (Preferred)
search this ID
Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13
Lira-Navarrete E, delasRivas M, Companon I, Pallares MC, Kong Y, Iglesias-Fernandez J, Bernardes GJL, Peregrina JM, Rovira C, Bernado P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R
Nat Commun
(2015)
[PMID: 25939779 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Mucin-5AC
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161349 (Preferred)
search this ID
Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13
Lira-Navarrete E, delasRivas M, Companon I, Pallares MC, Kong Y, Iglesias-Fernandez J, Bernardes GJL, Peregrina JM, Rovira C, Bernado P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R
Nat Commun
(2015)
[PMID: 25939779 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form and Mucin-5AC
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161349 (Preferred)
search this ID
Entries 1 to 10 of 13