Uniprot accession / id : Q6WKZ8  OR   Uniprot accession / id : Q8IWV8
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (1)
X-ray diffraction
(6)
 
Authors  (9)
Gehring K
(6)
Kozlov G
(6)
Matta-Camacho E
(6)
Cho C
(4)
Munoz-Escobar J
(4)
Muñoz-Escobar J
(4)
Li F
(2)
Li FF
(2)
Munoz Escobar J
(1)
 
Homo / hetero assembly  (2)
hetero
(4)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(4)
protein structure
(2)
 
Assembly polymer count  (2)
dimer
(4)
monomer
(2)
 
Resolution distribution
0.5 - 1
(1)
1.0 - 1.5
(2)
1.5 - 2
(2)
2.5 - 3
(1)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(2)
2015 - 2020
(4)
 
Journal  (2)
Structure
(4)
Nat Struct Mol Biol
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (1)
Homo sapiens
(6)
 
Molecule name  (4)
E3 ubiquitin-protein ligase UBR2
(6)
N-recognin-2
(6)
Ubiquitin-protein ligase E3-alpha-2
(6)
Ubiquitin-protein ligase E3-alpha-II
(6)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (3)
C6orf133
(6)
KIAA0349
(6)
UBR2
(6)
 
Interacting Molecules  (4)
ARG-LEU-TRP-SER peptide
(1)
DA2-ILE-PHE-SER peptide
(1)
HIS-ILE-PHE-SER peptide
(1)
N-degron
(1)
 
Interacting ligands  (2)
ZN : ZINC ION
(6)
EDO : 1,2-ETHANEDIOL
(2)
 
Function and Biology
EC number / name  (1)
2.3.2.27 : RING-type E3 ubiquitin transferase
(6)
 
Biological function  (2)
ubiquitin protein ligase activity
(6)
zinc ion binding
(6)
 
Biological process  (1)
ubiquitin-dependent protein catabolic process via the N-end rule pathway
(6)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF02207 : zf-UBR
(6)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (2)
Synchrotron
(5)
Rotating anode
(1)
 
Diffraction source  (2)
CHESS BEAMLINE A1
(5)
RIGAKU
(1)
 
Synchrotron site  (1)
CHESS
(5)
 
Diffraction detector type  (2)
CCD
(5)
Image plate
(1)
 
Refinement software  (2)
PHENIX
(4)
REFMAC
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Crystal structure of the UBR-box domain from UBR2 in complex with RLWS N-degron
Munoz-Escobar J, Kozlov G, Gehring K
Structure (2017) [PMID: 28392261  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase UBR2 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-166106 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
0.79Å resolution
Released: 22 Mar 2017
Model geometry
Fit model/data
5tda
5tda
5tda
Crystal structure of the human UBR-box domain from UBR2 in complex with asymmetrically double methylated arginine peptide
Munoz-Escobar J, Kozlov G, Gehring K
Structure (2017) [PMID: 28392261  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN    EDO   
Modified residues: DA2    DA2   
Assembly name: E3 ubiquitin-protein ligase UBR2 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-166107 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
1.101Å resolution
Released: 22 Mar 2017
Model geometry
Fit model/data
5tdb
5tdb
5tdb
Human UBR-box from UBR2 in complex with HIFS peptide
Munoz-Escobar J, Kozlov G, Gehring K
Structure (2017) [PMID: 28392261  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN    EDO   
Assembly name: E3 ubiquitin-protein ligase UBR2 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-166109 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
1.55Å resolution
Released: 22 Mar 2017
Model geometry
Fit model/data
5tdd
5tdd
5tdd
Crystal structure of the V122L mutant of human UBR-box domain from UBR2
Munoz Escobar J, Kozlov G, Gehring K
Structure (2017) [PMID: 28392261  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase UBR2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184900 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
1.198Å resolution
Released: 22 Mar 2017
Model geometry
Fit model/data
5um3
5um3
5um3
Structure of the ubr-box of UBR2 ubiquitin ligase
Matta-Camacho E, Kozlov G, Li F, Gehring K
Nat Struct Mol Biol (2010) [PMID: 20835242  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase UBR2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-184900 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
2.61Å resolution
Released: 11 Aug 2010
Model geometry
Fit model/data
3ny2
3ny2
3ny2
Structure of the ubr-box of UBR2 in complex with N-degron
Matta-Camacho E, Kozlov G, Li F, Gehring K
Nat Struct Mol Biol (2010) [PMID: 20835242  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase UBR2 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163829 (Preferred)   search this ID
PDBe-KB: Q8IWV8   
X-ray diffraction
1.6Å resolution
Released: 11 Aug 2010
Model geometry
Fit model/data
3ny3
3ny3
3ny3
Entries 1 to 6 of 6
Entries 1 to 6 of 6