Uniprot accession / id : Q8BND5  OR   Uniprot accession / id : O00391
 
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Entry Information
Entry status  (1)
REL
(10)
 
Experimental methods  (1)
X-ray diffraction
(10)
 
Authors  (17)
Fass D
(10)
Alon A
(7)
Grossman I
(7)
Ilani T
(5)
Thorpe C
(5)
Baker D
(3)
DiMaio F
(3)
Fleishman SJ
(3)
Gat Y
(3)
Haran G
(3)
Kodali VK
(3)
Mehlman T
(3)
Heckler EJ
(2)
Grossman-Haham I
(1)
Javitt G
(1)
Mutsafi Y
(1)
Resnick E
(1)
 
Homo / hetero assembly  (2)
homo
(6)
hetero
(4)
 
Assembly composition  (2)
protein structure
(6)
protein/protein complex
(4)
 
Assembly polymer count  (3)
monomer
(6)
trimer
(3)
hexamer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(6)
2.5 - 3
(2)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(6)
2015 - 2020
(4)
 
Journal  (5)
Nature
(3)
Protein Eng Des Sel
(3)
FEBS Lett
(2)
J Mol Biol
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(10)
 
Organism name  (2)
Mus musculus
(6)
Homo sapiens
(4)
 
Molecule name  (5)
Quiescin Q6
(10)
Sulfhydryl oxidase 1
(10)
Skin sulfhydryl oxidase
(6)
mSOx
(6)
hQSOX
(4)
 
Molecule type  (1)
Protein
(10)
 
Gene names  (6)
Qscn6
(6)
Qsox1
(6)
Sox
(6)
QSCN6
(4)
QSOX1
(4)
UNQ2520/PRO6013
(4)
 
Interacting Molecules  (8)
Fab 316 heavy chain
(1)
Fab 316 light chain
(1)
Heavy Chain of Fab Fragment from a Mouse QSOX1-Specific Antibody
(1)
Heavy chain of FAB fragment
(1)
Heavy chain of Fab fragment from an antibody targeting mouse and human QSOX1
(1)
Light Chain of Fab Fragment from a Mouse QSOX1-Specific Antibody
(1)
Light chain of FAB fragment
(1)
Light chain of Fab fragment from an antibody targeting mouse and human QSOX1
(1)
 
Interacting ligands  (4)
FAD : FLAVIN-ADENINE DINUCLEOTIDE
(4)
FLC : CITRATE ANION
(1)
PO4 : PHOSPHATE ION
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
EC number / name  (1)
1.8.3.2 : Thiol oxidase
(10)
 
Biological function  (2)
flavin-dependent sulfhydryl oxidase activity
(10)
thiol oxidase activity
(4)
 
Compound cofactor class  (1)
Flavin adenine dinucleotide
(4)
 
Sequence and Structure classification
CATH class  (2)
Alpha Beta
(7)
Mainly Alpha
(3)
 
CATH topology  (2)
Glutaredoxin
(7)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(3)
 
Pfam accession / name  (4)
PF00085 : Thioredoxin
(8)
PF18108 : QSOX_Trx1
(8)
PF04777 : Evr1_Alr
(4)
PF18371 : FAD_SOX
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(10)
 
Diffraction radiation source type  (2)
Rotating anode
(8)
Synchrotron
(2)
 
Diffraction source  (3)
RIGAKU RUH3R
(8)
ESRF BEAMLINE ID23-1
(1)
ESRF BEAMLINE ID29
(1)
 
Synchrotron site  (1)
ESRF
(2)
 
Diffraction detector type  (2)
Image plate
(8)
Pixel
(2)
 
Refinement software  (2)
CNS
(6)
PHENIX
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 10
Entries 1 to 10 of 10
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Sulfhydryl Oxidase Fragment of Human QSOX1
Alon A, Fass D
FEBS Lett (2010) [PMID: 20211621  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FAD    FAD    FLC   
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126252 (Preferred)   search this ID
PDBe-KB: O00391   
X-ray diffraction
2Å resolution
Released: 31 Mar 2010
Model geometry
Fit model/data
3llk
3llk
3llk
C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide
Fass D, Alon A, Gat Y
Nature (2012) [PMID: 22801504  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: FAD    FAD   
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183891 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
2.8Å resolution
Released: 30 May 2012
Model geometry
Fit model/data
3t59
3t59
3t59
C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide
Fass D, Alon A, Gat Y
Nature (2012) [PMID: 22801504  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: FAD    FAD   
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183891 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
2.4Å resolution
Released: 30 May 2012
Model geometry
Fit model/data
3t58
3t58
3t58
Oxidoreductase Fragment of Human QSOX1 in Complex with a FAB Fragment from an Anti- Human QSOX1 Antibody
Fass D, Grossman I
J Mol Biol (2013) [PMID: 23867277  ]
Assembly composition: protein/protein complex
Bound ligands: PO4   
Assembly name: Sulfhydryl oxidase 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-234975 (Preferred)   search this ID
PDBe-KB: O00391   
X-ray diffraction
2.7Å resolution
Released: 6 Nov 2013
Model geometry
Fit model/data
4ij3
4ij3
4ij3
Mutant oxidoreductase fragment of mouse QSOX1 in complex with an antibody Fab
Grossman-Haham I, Fass D
Protein Sci (2019) [PMID: 30367560  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Assembly name: Sulfhydryl oxidase 1 and IG-heavy chain and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212569 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
1.94Å resolution
Released: 3 Apr 2019
Model geometry
Fit model/data
6hf1
6hf1
6hf1
Engineering the Species-Specificity of an Inhibitory Antibody Targeting a Modulator of Tumor Stroma
Grossman I, Fass D
Protein Eng Des Sel (2016) [PMID: 26819240  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183891 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
2.05Å resolution
Released: 10 Feb 2016
Model geometry
Fit model/data
5d8i
5d8i
5d8i
Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from an Antibody Targeting Mouse and Human QSOX1
Fass D, Grossman I
Protein Eng Des Sel (2016) [PMID: 26819240  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Assembly name: Sulfhydryl oxidase 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212568 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
2.3Å resolution
Released: 10 Feb 2016
Model geometry
Fit model/data
5d96
5d96
5d96
Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from a Mouse QSOX1-Specific Antibody
Grossman I, Fass D
Protein Eng Des Sel (2016) [PMID: 26819240  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Assembly name: Sulfhydryl oxidase 1 and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212567 (Preferred)   search this ID
PDBe-KB: Q8BND5   
X-ray diffraction
2.201Å resolution
Released: 10 Feb 2016
Model geometry
Fit model/data
5d93
5d93
5d93
Sulfhydryl Oxidase Fragment of Human QSOX1
Alon A, Fass D
FEBS Lett (2010) [PMID: 20211621  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FAD    FAD   
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126252 (Preferred)   search this ID
PDBe-KB: O00391   
X-ray diffraction
2.05Å resolution
Released: 23 Mar 2010
Model geometry
Fit model/data
3lli
3lli
3lli
Oxidoreductase Fragment of Human QSOX1
Fass D, Alon A
Nature (2012) [PMID: 22801504  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Modified residues: MLY    MLY   
Assembly name: Sulfhydryl oxidase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126252 (Preferred)   search this ID
PDBe-KB: O00391   
X-ray diffraction
2.05Å resolution
Released: 30 May 2012
Model geometry
Fit model/data
3q6o
3q6o
3q6o
Entries 1 to 10 of 10
Entries 1 to 10 of 10