Entries released this week  (1)

new

(1)

Entry status  (1)

REL

(10)

Experimental methods  (3)

Electron Microscopy

(4)

X-ray diffraction

(4)

Solution NMR

(2)

Authors  (53)

Chen Y

(4)

Choi HW

(4)

Hu L

(4)

Liao M

(4)

Mungenast A

(4)

Plummer-Medeiros AM

(4)

Poda SB

(4)

Qian D

(4)

Sanders K

(4)

Shepard J

(4)

Shin YC

(4)

Song K

(4)

TenDyke K

(4)

Wang J

(4)

Xu C

(4)

Zhu X

(4)

Zhuang N

(4)

Bunney TD

(3)

Everett KL

(3)

Gierschik P

(3)

Josephs MB

(3)

Katan M

(3)

Shin Y-C

(3)

Vatter P

(3)

Walliser C

(3)

Baxendale RW

(2)

Christow C

(2)

Opaleye O

(2)

Pearl LH

(2)

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(2)

Rodrigues-Lima F

(2)

Roe SM

(2)

Yokoyama S

(2)

Choi H

(1)

Driscoll PC

(1)

Esposito D

(1)

Faille A

(1)

Faille AJ

(1)

Handa N

(1)

Harris R

(1)

Hayahsi F

(1)

Hayashi F

(1)

Kurosaki T

(1)

Murayama K

(1)

Nagashima T

(1)

Qamar S

(1)

Qin XR

(1)

Retlich M

(1)

Shirouzu M

(1)

St George-Hyslop P

(1)

Takagi T

(1)

Terada T

(1)

Warren AJ

(1)

Homo / hetero assembly  (2)

homo

(8)

hetero

(2)

Assembly composition  (2)

protein structure

(8)

protein/protein complex

(2)

Assembly polymer count  (2)

monomer

(7)

dimer

(3)

Resolution distribution

2.0 - 2.5

(2)

2.5 - 3

(2)

3.0 - 3.5

(1)

3.5 - 4

(1)

4.0 - 4.5

(2)

Release year distribution

2005 - 2010

(5)

2020 - 2025

(5)

2025 - 2030

(1)

Journal  (4)

Sci Adv

(4)

To be published

(3)

Mol Cell

(2)

J Biol Chem

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (2)

Homo sapiens

(8)

Mus musculus

(2)

Molecule name  (6)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

(10)

PLC-gamma-2

(10)

Phosphoinositide phospholipase C-gamma-2

(10)

Phospholipase C-gamma-2

(10)

PLC-IV

(8)

Phospholipase C-IV

(8)

Molecule type  (1)

Protein

(10)

Gene names  (2)

PLCG2

(8)

Plcg2

(2)

Interacting Molecules  (2)

Fibroblast growth factor receptor 1

(1)

Ras-related C3 botulinum toxin substrate 2

(1)

Interacting ligands  (3)

CA : CALCIUM ION

(1)

EDO : 1,2-ETHANEDIOL

(1)

SO4 : SULFATE ION

(1)

EC number / name  (1)

3.1.4.11 : Phosphoinositide phospholipase C

(10)

Biological function  (10)

phosphatidylinositol-4,5-bisphosphate phospholipase C activity

(4)

hydrolase activity

(3)

phospholipase C activity

(3)

phosphorylation-dependent protein binding

(3)

phosphotyrosine residue binding

(3)

protein binding

(3)

protein kinase binding

(3)

protein tyrosine kinase binding

(3)

scaffold protein binding

(3)

phosphoric diester hydrolase activity

(1)

Biological process  (58)

intracellular signal transduction

(4)

lipid metabolic process

(4)

signal transduction

(4)

B cell activation

(3)

B cell differentiation

(3)

B cell receptor signaling pathway

(3)

Fc-epsilon receptor signaling pathway

(3)

T cell receptor signaling pathway

(3)

Wnt signaling pathway

(3)

antifungal innate immune response

(3)

calcium-mediated signaling

(3)

cell activation

(3)

cellular response to calcium ion

(3)

cellular response to lectin

(3)

cellular response to lipid

(3)

follicular B cell differentiation

(3)

inositol trisphosphate biosynthetic process

(3)

lipid catabolic process

(3)

lipopolysaccharide-mediated signaling pathway

(3)

macrophage activation involved in immune response

(3)

negative regulation of programmed cell death

(3)

phosphatidylinositol biosynthetic process

(3)

phosphatidylinositol metabolic process

(3)

phosphatidylinositol-mediated signaling

(3)

platelet activation

(3)

positive regulation of MAPK cascade

(3)

positive regulation of NLRP3 inflammasome complex assembly

(3)

positive regulation of calcium-mediated signaling

(3)

positive regulation of canonical NF-kappaB signal transduction

(3)

positive regulation of cell cycle G1/S phase transition

(3)

positive regulation of dendritic cell cytokine production

(3)

positive regulation of epithelial cell migration

(3)

positive regulation of gene expression

(3)

positive regulation of interleukin-10 production

(3)

positive regulation of interleukin-12 production

(3)

positive regulation of interleukin-2 production

(3)

positive regulation of interleukin-23 production

(3)

positive regulation of interleukin-6 production

(3)

positive regulation of intracellular signal transduction

(3)

positive regulation of macrophage cytokine production

(3)

positive regulation of neuroinflammatory response

(3)

positive regulation of phagocytosis, engulfment

(3)

positive regulation of reactive oxygen species biosynthetic process

(3)

positive regulation of receptor internalization

(3)

positive regulation of tumor necrosis factor production

(3)

positive regulation of type I interferon production

(3)

programmed cell death

(3)

regulation of calcineurin-NFAT signaling cascade

(3)

regulation of canonical NF-kappaB signal transduction

(3)

regulation of gene expression

(3)

regulation of lipid metabolic process

(3)

release of sequestered calcium ion into cytosol

(3)

response to axon injury

(3)

response to lipopolysaccharide

(3)

response to yeast

(3)

stimulatory C-type lectin receptor signaling pathway

(3)

toll-like receptor signaling pathway

(3)

phospholipid catabolic process

(1)

Biological cell component  (9)

cytoplasm

(3)

cytosol

(3)

extracellular exosome

(3)

intracellular vesicle

(3)

membrane

(3)

membrane raft

(3)

perinuclear region of cytoplasm

(3)

plasma membrane

(3)

ruffle membrane

(3)

CATH class  (2)

Mainly Beta

(4)

Alpha Beta

(1)

CATH topology  (3)

PH-domain like

(3)

SH3 type barrels.

(1)

SHC Adaptor Protein

(1)

Pfam accession / name  (6)

PF00017 : SH2

(6)

PF00018 : SH3_1

(6)

PF00168 : C2

(5)

PF00387 : PI-PLC-Y

(5)

PF00388 : PI-PLC-X

(5)

PF16457 : PH_12

(5)

Diffraction protocol  (2)

Single wavelength

(3)

MAD

(1)

Diffraction radiation source type  (1)

Synchrotron

(4)

Diffraction source  (4)

DIAMOND BEAMLINE I03

(1)

ESRF BEAMLINE ID29

(1)

SPRING-8 BEAMLINE BL26B2

(1)

SSRF BEAMLINE BL19U1

(1)

Synchrotron site  (4)

Diamond

(1)

ESRF

(1)

SPring-8

(1)

SSRF

(1)

Diffraction detector type  (2)

CCD

(3)

Pixel

(1)

Refinement software  (3)

PHENIX

(2)

CNS

(1)

REFMAC

(1)

EM microscope model  (2)

FEI TALOS ARCTICA

(3)

TFS KRIOS

(1)

EM detector name  (2)

GATAN K3 (6k x 4k)

(3)

GATAN K3 BIOQUANTUM (6k x 4k)

(1)

NMR software packages  (6)

CNS

(1)

CYANA

(1)

KUJIRA

(1)

NMRPipe

(1)

NMRView

(1)

VNMR

(1)

NMR Field Strength

400.0 - 500

(1)

500.0 - 600

(1)

600.0 - 700

(1)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

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