Entry status  (1)

REL

(60)

Experimental methods  (1)

X-ray diffraction

(60)

Authors  (187)

Flanagan JU

(18)

Turnbull AP

(15)

Squire CJ

(13)

Yosaatmadja Y

(13)

Chen Y

(11)

Chai MZ

(10)

Teague RM

(10)

Chu X

(7)

Fang P

(7)

Feng F

(7)

Guo Q

(7)

He S

(7)

Jiang J

(7)

Liu W

(7)

Liu Y

(7)

Sun H

(7)

Zhao L

(7)

Amano Y

(6)

Niimi T

(6)

Sakashita H

(6)

Yamaguchi T

(6)

Yang P

(6)

Zhang H

(6)

Zhang X

(6)

Zhao Y

(6)

Boschi D

(5)

Denny WA

(5)

Hu X

(5)

Jamieson SM

(5)

Jamieson SMF

(5)

Li C

(5)

Lolli ML

(5)

Oliaro-Bosso S

(5)

Owen PJ

(5)

Pippione AC

(5)

Raynham T

(5)

Rigoreau LJ

(5)

Rigoreau LJM

(5)

Samlal SS

(5)

Schroeder E

(5)

Silva S

(5)

Soudy C

(5)

Trivier E

(5)

Zheng X

(5)

Zonari D

(5)

Adinolfi S

(4)

Atwell GJ

(4)

Brooke DG

(4)

Bunce CM

(4)

Cummings SM

(4)

Desmond JC

(4)

Heinrich D

(4)

Li Z

(4)

Lovering AL

(4)

Ride JP

(4)

White SA

(4)

Wu Y

(4)

Adeniji AO

(3)

Bagnati R

(3)

Bonanni D

(3)

Carnovale IM

(3)

Chai M

(3)

Chen M

(3)

Christianson DW

(3)

Endo S

(3)

Friemann R

(3)

Fujii S

(3)

Fujimoto N

(3)

Gouda H

(3)

Goyal P

(3)

Hamilton EJ

(3)

Hu D

(3)

Iguchi K

(3)

Ikari A

(3)

Irie K

(3)

Kawai M

(3)

Komoto J

(3)

Labrie F

(3)

Li Q

(3)

Lin SX

(3)

Marini E

(3)

Matsukawa T

(3)

Matsunaga T

(3)

Nakayama T

(3)

Oguri H

(3)

Okada T

(3)

Pan D

(3)

Penning TM

(3)

Pors K

(3)

Qiu W

(3)

Qiu Z

(3)

Segawa J

(3)

Takusagawa F

(3)

Toyooka N

(3)

Wahlgren WY

(3)

Watanabe K

(3)

Xia S

(3)

Xiao Y

(3)

Xie H

(3)

Xing S

(3)

 

More...

Homo / hetero assembly  (1)

homo

(60)

Assembly composition  (1)

protein structure

(60)

Assembly polymer count  (2)

monomer

(57)

dimer

(3)

Resolution distribution

1.0 - 1.5

(6)

1.5 - 2

(38)

2.0 - 2.5

(13)

2.5 - 3

(3)

Release year distribution

2000 - 2005

(7)

2005 - 2010

(3)

2010 - 2015

(30)

2015 - 2020

(18)

2020 - 2025

(14)

Journal  (15)

J Med Chem

(10)

PLoS One

(10)

Eur J Med Chem

(7)

Acta Crystallogr D Biol Crystallogr

(6)

To be published

(5)

Cancer Res

(4)

Chem Biol Interact

(4)

Biochemistry

(3)

ACS Med Chem Lett

(2)

Bioorg Med Chem

(2)

Bioorg Med Chem Lett

(2)

J Biol Chem

(2)

Acta Crystallogr Sect F Struct Biol Cryst Commun

(1)

Mol Endocrinol

(1)

RSC Med Chem

(1)

Organism superkingdom  (1)

Eukaryota

(60)

Organism name  (1)

Homo sapiens

(60)

Molecule name  (15)

17-beta-HSD 5

(60)

17-beta-hydroxysteroid dehydrogenase type 5

(60)

3-alpha-HSD type 2

(60)

3-alpha-HSD type II, brain

(60)

3-alpha-hydroxysteroid dehydrogenase type 2

(60)

Aldo-keto reductase family 1 member C3

(60)

Chlordecone reductase homolog HAKRb

(60)

DD-3

(60)

DD3

(60)

Dihydrodiol dehydrogenase 3

(60)

Dihydrodiol dehydrogenase type I

(60)

HA1753

(60)

PGFS

(60)

Prostaglandin F synthase

(60)

Testosterone 17-beta-dehydrogenase 5

(60)

Molecule type  (1)

Protein

(60)

Gene names  (5)

AKR1C3

(60)

DDH1

(60)

HSD17B5

(60)

KIAA0119

(60)

PGFS

(60)

Interacting ligands  (66)

NAP : NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

(59)

EDO : 1,2-ETHANEDIOL

(21)

ACT : ACETATE ION

(8)

DMS : DIMETHYL SULFOXIDE

(3)

IMN : INDOMETHACIN

(3)

MPD : (4S)-2-METHYL-2,4-PENTANEDIOL

(2)

0HV : 3-[(4-nitronaphthalen-1-yl)amino]benzoic acid

(1)

0SL : (3R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid

(1)

0SZ : 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid

(1)

0T0 : 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-methylbenzamide

(1)

10H : 1-(4-{[(2R)-2-methylpiperidin-1-yl]sulfonyl}phenyl)-1,3-dihydro-2H-pyrrol-2-one

(1)

15M : (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE

(1)

16J : [4-(4-chlorophenyl)piperazin-1-yl](morpholin-4-yl)methanone

(1)

4IV : 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide

(1)

4R6 : ~{N}-(3-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzamide

(1)

4ZI : 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide

(1)

511 : [1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetic acid

(1)

65D : octyl 3,4,5-trihydroxybenzoate

(1)

8FO : (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid

(1)

8IH : (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid

(1)

8IT : (2~{R})-2-(3-fluoranyl-4-pyrimidin-5-yl-phenyl)butanoic acid

(1)

9S0 : (4R)-6-amino-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

(1)

A1ICG : ~{N}-(4-bromanyl-2-methyl-phenyl)-2-[methyl-[(8-methyl-7-oxidanyl-2-oxidanylidene-chromen-4-yl)methyl]amino]ethanamide

(1)

ASD : 4-ANDROSTENE-3-17-DIONE

(1)

BT9 : 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid

(1)

CJ2 : 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide

(1)

CL : CHLORIDE ION

(1)

CVN : 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one

(1)

DFV : 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE

(1)

DMF : DIMETHYLFORMAMIDE

(1)

E04 : 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN

(1)

FFW : 4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one

(1)

FJR : 2-azanylidene-N-(4-methylphenyl)-8-oxidanyl-chromene-3-carboxamide

(1)

FJU : 2-azanylidene-N-(3-ethylphenyl)-8-oxidanyl-chromene-3-carboxamide

(1)

FLF : 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID

(1)

FLR : (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid

(1)

GBM : 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide

(1)

GCZ : N-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl]-4-methylbenzenesulfonamide

(1)

GMR : 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide

(1)

ID8 : 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID

(1)

IZP : (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid

(1)

JMS : 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid

(1)

JTN : 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid

(1)

MES : 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

(1)

NA : SODIUM ION

(1)

NDP : NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

(1)

NPS : (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

(1)

NPX : (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid

(1)

P6G : HEXAETHYLENE GLYCOL

(1)

PG2 : PROSTAGLANDIN D2

(1)

PG4 : TETRAETHYLENE GLYCOL

(1)

QAP : 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

(1)

QBO : (4~{R})-4-[(1~{R},2~{S},5~{R},6~{R},13~{S},14~{S},17~{R},19~{R})-6,14-dimethyl-17-oxidanyl-7,8,9,10-tetrazapentacyclo[11.8.0.0^{2,6}.0^{7,11}.0^{14,19}]henicosa-8,10-dien-5-yl]pentanoic acid

(1)

RUT : RUTIN

(1)

SUZ : [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid

(1)

VJJ : 3-phenoxybenzoic acid

(1)

WDS : 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one

(1)

WDT : 2-nitro-5-(phenylsulfonyl)phenol

(1)

WDU : 4-chloro-N-(4-chlorobenzyl)-5-nitro-1H-pyrazole-3-carboxamide

(1)

WDV : 4-nitro-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)phenol

(1)

WDW : 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone

(1)

WDX : [4-(2-hydroxyethyl)piperidin-1-yl](5-methyl-1H-indol-2-yl)methanone

(1)

YMC : 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol

(1)

YY1 : 5-methyl-4H-1,2,4-triazole-3-thiol

(1)

YY2 : 2-[4-(aminomethyl)-2-chloro-6-methoxyphenoxy]-N-tert-butylacetamide

(1)

ZOM : [5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid

(1)

EC number / name  (7)

1.1.1.188 : Prostaglandin-F synthase

(60)

1.1.1.210 : 3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase

(60)

1.1.1.239 : 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))

(60)

1.1.1.357 : 3-alpha-hydroxysteroid 3-dehydrogenase

(60)

1.1.1.53 : 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase

(60)

1.1.1.62 : 17-beta-estradiol 17-dehydrogenase

(60)

1.1.1.64 : Testosterone 17-beta-dehydrogenase (NADP(+))

(60)

Biological function  (24)

15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

(60)

5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity

(60)

Delta4-3-oxosteroid 5beta-reductase activity

(60)

aldose reductase (NADPH) activity

(60)

all-trans-retinol dehydrogenase (NAD+) activity

(60)

all-trans-retinol dehydrogenase (NADP+) activity

(60)

androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity

(60)

androsterone dehydrogenase [NAD(P)+] activity

(60)

bile acid binding

(60)

estradiol 17-beta-dehydrogenase [NAD(P)+] activity

(60)

geranylgeranyl reductase activity

(60)

ketoreductase activity

(60)

ketosteroid monooxygenase activity

(60)

obsolete aldo-keto reductase (NADPH) activity

(60)

oxidoreductase activity

(60)

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

(60)

prostaglandin D2 11-ketoreductase activity

(60)

prostaglandin F synthase activity

(60)

prostaglandin H2 endoperoxidase reductase activity

(60)

protein binding

(60)

retinal dehydrogenase activity

(60)

testosterone 17-beta-dehydrogenase (NADP+) activity

(60)

testosterone dehydrogenase (NAD+) activity

(60)

testosterone dehydrogenase [NAD(P)+] activity

(60)

Biological process  (31)

G protein-coupled receptor signaling pathway

(60)

cellular response to calcium ion

(60)

cellular response to corticosteroid stimulus

(60)

cellular response to jasmonic acid stimulus

(60)

cellular response to prostaglandin D stimulus

(60)

cellular response to prostaglandin stimulus

(60)

cellular response to starvation

(60)

daunorubicin metabolic process

(60)

doxorubicin metabolic process

(60)

farnesol catabolic process

(60)

keratinocyte differentiation

(60)

lipid metabolic process

(60)

macromolecule metabolic process

(60)

male gonad development

(60)

negative regulation of retinoic acid biosynthetic process

(60)

positive regulation of cell population proliferation

(60)

positive regulation of endothelial cell apoptotic process

(60)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

(60)

positive regulation of reactive oxygen species metabolic process

(60)

progesterone metabolic process

(60)

prostaglandin metabolic process

(60)

prostanoid biosynthetic process

(60)

regulation of retinoic acid receptor signaling pathway

(60)

regulation of testosterone biosynthetic process

(60)

renal absorption

(60)

response to nutrient

(60)

retinal metabolic process

(60)

retinoid metabolic process

(60)

retinol metabolic process

(60)

steroid metabolic process

(60)

testosterone biosynthetic process

(60)

Biological cell component  (4)

cytoplasm

(60)

cytosol

(60)

extracellular exosome

(60)

nucleus

(60)

Compound cofactor class  (1)

Nicotinamide-adenine dinucleotide

(60)

SCOP fold  (1)

TIM beta/alpha-barrel

(10)

SCOP family  (1)

Aldo-keto reductases (NADP)

(10)

CATH class  (1)

Alpha Beta

(45)

CATH topology  (1)

TIM Barrel

(45)

Pfam accession / name  (1)

PF00248 : Aldo_ket_red

(60)

Diffraction protocol  (1)

Single wavelength

(60)

Diffraction radiation source type  (3)

Synchrotron

(43)

Rotating anode

(11)

Sealed tube

(6)

Diffraction source  (26)

AUSTRALIAN SYNCHROTRON BEAMLINE MX2

(9)

RIGAKU MICROMAX-007 HF

(7)

OXFORD DIFFRACTION ENHANCE ULTRA

(5)

PHOTON FACTORY BEAMLINE AR-NW12A

(4)

NSLS BEAMLINE X8C

(3)

SPRING-8 BEAMLINE BL41XU

(3)

SSRF BEAMLINE BL17U1

(3)

APS BEAMLINE 19-BM

(2)

ESRF BEAMLINE ID14-2

(2)

ESRF BEAMLINE ID23-1

(2)

MAX IV BEAMLINE BioMAX

(2)

NSLS BEAMLINE X29A

(2)

RIGAKU FR-E+ SUPERBRIGHT

(2)

SSRF BEAMLINE BL02U1

(2)

AUSTRALIAN SYNCHROTRON BEAMLINE MX1

(1)

BESSY BEAMLINE 14.1

(1)

DIAMOND BEAMLINE I04

(1)

ESRF BEAMLINE ID14-1

(1)

ESRF BEAMLINE ID29

(1)

ESRF BEAMLINE ID30B

(1)

NFPSS BEAMLINE BL19U1

(1)

NSLS BEAMLINE X25

(1)

OXFORD DIFFRACTION NOVA

(1)

RIGAKU

(1)

RIGAKU RU200

(1)

SSRF BEAMLINE BL19U1

(1)

Synchrotron site  (11)

Australian Synchrotron

(10)

ESRF

(7)

NSLS

(6)

SSRF

(6)

Photon Factory

(4)

SPring-8

(3)

APS

(2)

MAX IV

(2)

BESSY

(1)

Diamond

(1)

NFPSS

(1)

Diffraction detector type  (3)

CCD

(38)

Pixel

(16)

Image plate

(6)

Refinement software  (3)

REFMAC

(40)

PHENIX

(20)

X-PLOR

(3)

Representative Structures

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