Uniprot accession / id : Q8K0H5  OR   Uniprot accession / id : Q12962
 
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Latest PDB release
Entries released this week  (1)
revised
(1)
 
Entry Information
Entry status  (1)
REL
(47)
 
Experimental methods  (2)
Electron Microscopy
(32)
X-ray diffraction
(15)
 
Authors  (86)
Chen X
(25)
Liu W
(25)
Wang X
(25)
Xu Y
(25)
Ren Y
(23)
Li J
(17)
Qi Y
(15)
Wu Z
(15)
Trievel RC
(14)
Hou H
(13)
Houtz RL
(13)
Li Y
(13)
Li Z
(13)
Wang M
(13)
Yang H
(13)
Yu Z
(13)
Zhao D
(13)
Dirk LM
(11)
Qu X
(10)
Couture J-F
(9)
Couture JF
(9)
Del Rizzo PA
(9)
Brunzelle JS
(8)
Li W
(8)
Roiko MS
(8)
Strunk BS
(8)
Wang Q
(8)
Louder RK
(6)
Nogales E
(6)
Horowitz S
(5)
Al-Hashimi HM
(4)
Fang J
(4)
Greber BJ
(4)
Grunberg S
(4)
Grünberg S
(4)
Hahn S
(4)
Liu Y
(4)
Luo J
(4)
Mehl RA
(4)
Nimtz JS
(4)
Patel AB
(4)
Ranish J
(4)
Scheiner S
(4)
Yesselman JD
(4)
Yin X
(4)
Adhikari U
(3)
Dailey GM
(2)
Darzacq X
(2)
Dugast-Darzacq C
(2)
Esbin MN
(2)
Fang Q
(2)
Herbst DA
(2)
Tjian R
(2)
Berger I
(1)
Butcher SE
(1)
Chavant V
(1)
Chen Z
(1)
Collazo E
(1)
Conic S
(1)
Dirk LMA
(1)
Ebong IO
(1)
Fick RJ
(1)
Fournier M
(1)
Haffke M
(1)
Hauk G
(1)
Huang J
(1)
Jing W
(1)
Kroner GM
(1)
Magnani R
(1)
Nepal B
(1)
Papai G
(1)
Peng C
(1)
Rappsilber J
(1)
Robinson CV
(1)
Schaffitzel C
(1)
Scheer E
(1)
Schultz P
(1)
Tora L
(1)
Trowitzsch S
(1)
Vander Meulen KA
(1)
Viola C
(1)
Wei M
(1)
Yin C
(1)
Yin Y
(1)
Zhang Y
(1)
Zou J
(1)
 
Homo / hetero assembly  (1)
hetero
(47)
 
Assembly composition  (3)
protein/protein complex
(25)
DNA/protein complex
(14)
DNA/RNA/protein complex
(8)
 
Assembly polymer count  (16)
dimer
(15)
51-mer
(10)
39-mer
(3)
22-mer
(2)
24-mer
(2)
41-mer
(2)
76-mer
(2)
87-mer
(2)
decamer
(2)
dodecamer
(1)
heptadecamer
(1)
heptamer
(1)
icosamer
(1)
tetradecamer
(1)
tridecamer
(1)
undecamer
(1)
 
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(12)
2.5 - 3
(3)
3.0 - 3.5
(2)
3.5 - 4
(3)
4.0 - 4.5
(6)
5.0 - 5.5
(2)
5.5 - 6
(1)
6.0 - 6.5
(5)
6.5 - 7
(1)
7.0 - 7.5
(3)
8.5 - 9
(3)
9.5 - 10
(2)
19.0 - 19.5
(1)
22.5 - 23
(1)
 
Release year distribution
2005 - 2010
(9)
2010 - 2015
(13)
2015 - 2020
(6)
2020 - 2025
(28)
 
Journal  (8)
Science
(29)
J Biol Chem
(8)
J Am Chem Soc
(3)
Nat Struct Mol Biol
(3)
ACS Chem Biol
(1)
Cell Discov
(1)
Nat Commun
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(47)
 
Organism name  (1)
Homo sapiens
(47)
 
Molecule name  (6)
STAF28
(47)
TAF(II)30
(47)
TAFII-30
(47)
TAFII30
(47)
Transcription initiation factor TFIID 30 kDa subunit
(47)
Transcription initiation factor TFIID subunit 10
(47)
 
Molecule type  (1)
Protein
(47)
 
Gene names  (4)
TAF10
(47)
TAF2A
(47)
TAF2H
(47)
TAFII30
(47)
 
Interacting Molecules  (106)
Transcription initiation factor TFIID subunit 12
(32)
Transcription initiation factor TFIID subunit 9
(30)
Transcription initiation factor TFIID subunit 4
(29)
Transcription initiation factor TFIID subunit 5
(29)
Transcription initiation factor TFIID subunit 6
(29)
Transcription initiation factor TFIID subunit 8
(28)
TATA-box-binding protein
(27)
Transcription initiation factor TFIID subunit 1
(26)
Transcription initiation factor TFIID subunit 11
(26)
Transcription initiation factor TFIID subunit 13
(26)
Transcription initiation factor TFIID subunit 2
(26)
Transcription initiation factor TFIID subunit 3
(26)
Transcription initiation factor TFIID subunit 7
(25)
Transcription initiation factor IIA subunit 2
(23)
Transcription initiation factor IIA subunit 1
(21)
DNA-directed RNA polymerase II subunit E
(19)
DNA-directed RNA polymerase II subunit RPB9
(19)
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
(19)
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
(19)
DNA-directed RNA polymerase subunit
(19)
DNA-directed RNA polymerase subunit beta
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC2
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC3
(19)
General transcription factor IIF subunit 1
(19)
General transcription factor IIF subunit 2
(19)
RNA polymerase II, I and III subunit K
(19)
RNA polymerase Rpb4/RPC9 core domain-containing protein
(19)
Transcription initiation factor IIB
(19)
General transcription factor IIE subunit 1
(16)
Transcription initiation factor IIE subunit beta
(16)
DNA-directed RNA polymerases I, II, and III subunit RPABC5
(15)
CDK-activating kinase assembly factor MAT1
(14)
General transcription and DNA repair factor IIH helicase subunit XPD
(14)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB
(14)
General transcription factor IIH subunit 1
(14)
General transcription factor IIH subunit 2
(14)
General transcription factor IIH subunit 3
(14)
General transcription factor IIH subunit 4
(14)
General transcription factor IIH subunit 5
(14)
Histone-lysine N-methyltransferase SETD7
(14)
Alpha-amanitin
(8)
RNA
(8)
non-template DNA
(8)
template DNA
(8)
Cyclin-H
(6)
Cyclin-dependent kinase 7
(6)
Mediator of RNA polymerase II transcription subunit 1
(4)
Mediator of RNA polymerase II transcription subunit 10
(4)
Mediator of RNA polymerase II transcription subunit 11
(4)
Mediator of RNA polymerase II transcription subunit 14
(4)
Mediator of RNA polymerase II transcription subunit 15
(4)
Mediator of RNA polymerase II transcription subunit 16
(4)
Mediator of RNA polymerase II transcription subunit 17
(4)
Mediator of RNA polymerase II transcription subunit 18
(4)
Mediator of RNA polymerase II transcription subunit 19
(4)
Mediator of RNA polymerase II transcription subunit 20
(4)
Mediator of RNA polymerase II transcription subunit 21
(4)
Mediator of RNA polymerase II transcription subunit 22
(4)
Mediator of RNA polymerase II transcription subunit 23
(4)
Mediator of RNA polymerase II transcription subunit 24
(4)
Mediator of RNA polymerase II transcription subunit 26
(4)
Mediator of RNA polymerase II transcription subunit 27
(4)
Mediator of RNA polymerase II transcription subunit 28
(4)
Mediator of RNA polymerase II transcription subunit 29
(4)
Mediator of RNA polymerase II transcription subunit 30
(4)
Mediator of RNA polymerase II transcription subunit 31
(4)
Mediator of RNA polymerase II transcription subunit 4
(4)
Mediator of RNA polymerase II transcription subunit 6
(4)
Mediator of RNA polymerase II transcription subunit 7
(4)
Mediator of RNA polymerase II transcription subunit 8
(4)
Mediator of RNA polymerase II transcription subunit 9
(4)
RPB10
(4)
Ataxin-7
(3)
DNA (69-MER)
(3)
STAGA complex 65 subunit gamma
(3)
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
(3)
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
(3)
Transcription factor SPT20 homolog
(3)
Transcription initiation protein SPT3 homolog
(3)
Transcriptional adapter 1
(3)
poly(UNK)
(3)
DNA (162-mer)
(2)
DNA (228-mer)
(2)
DNA (79-MER)
(2)
DNA (85-MER)
(2)
DNA-directed RNA polymerase II subunit RPB1
(2)
HISTONE H2A.Z
(2)
Histone H2B
(2)
Histone H3
(2)
Histone H4
(2)
Mediator of RNA polymerase II transcription subunit 25
(2)
RPB1
(2)
Splicing factor 3B subunit 3
(2)
Splicing factor 3B subunit 5
(2)
TFIIA-a
(2)
Transcription initiation factor TFIID subunit 9B
(2)
Transformation/transcription domain-associated protein
(2)
DNA (71-MER)
(1)
DNA (72-MER)
(1)
DNA (74-MER)
(1)
 
More...
 
Interacting ligands  (3)
SAH : S-ADENOSYL-L-HOMOCYSTEINE
(7)
CL : CHLORIDE ION
(1)
GOL : GLYCEROL
(1)
 
Function and Biology
Biological function  (9)
DNA binding
(32)
RNA polymerase II general transcription initiation factor activity
(32)
RNA polymerase binding
(32)
enzyme binding
(32)
histone acetyltransferase activity
(32)
identical protein binding
(32)
nuclear estrogen receptor binding
(32)
promoter-specific chromatin binding
(32)
protein binding
(32)
 
Biological process  (27)
DNA-templated transcription initiation
(33)
G1/S transition of mitotic cell cycle
(32)
RNA polymerase II preinitiation complex assembly
(32)
SAGA complex assembly
(32)
allantois development
(32)
apoptotic process
(32)
chromatin remodeling
(32)
embryonic placenta development
(32)
gene expression
(32)
hepatocyte differentiation
(32)
in utero embryonic development
(32)
lateral mesodermal cell differentiation
(32)
limb development
(32)
liver development
(32)
mRNA transcription by RNA polymerase II
(32)
multicellular organism growth
(32)
positive regulation of DNA-templated transcription
(32)
positive regulation of transcription initiation by RNA polymerase II
(32)
protein-containing complex assembly
(32)
regulation of DNA repair
(32)
regulation of DNA-templated transcription
(32)
regulation of RNA splicing
(32)
regulation of gene expression
(32)
regulation of transcription by RNA polymerase II
(32)
somitogenesis
(32)
transcription by RNA polymerase II
(32)
transcription initiation at RNA polymerase II promoter
(32)
 
Biological cell component  (9)
nucleus
(33)
SAGA complex
(32)
cytoplasm
(32)
male germ cell nucleus
(32)
nucleoplasm
(32)
perinuclear region of cytoplasm
(32)
transcription factor TFIID complex
(32)
transcription factor TFTC complex
(32)
transcription preinitiation complex
(32)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF03540 : TFIID_30kDa
(33)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(15)
 
Diffraction radiation source type  (1)
Synchrotron
(15)
 
Diffraction source  (5)
APS BEAMLINE 21-ID-G
(8)
APS BEAMLINE 23-ID-D
(3)
APS BEAMLINE 21-ID-D
(2)
APS BEAMLINE 17-ID
(1)
SOLEIL BEAMLINE PROXIMA 1
(1)
 
Synchrotron site  (2)
APS
(14)
SOLEIL
(1)
 
Diffraction detector type  (2)
CCD
(14)
Pixel
(1)
 
Refinement software  (3)
REFMAC
(13)
PHENIX
(8)
phenix.real_space_refine
(1)
 
EM microscope model  (3)
FEI TITAN KRIOS
(27)
FEI TITAN
(4)
FEI TECNAI 20
(1)
 
EM detector name  (4)
GATAN K2 SUMMIT (4k x 4k)
(19)
GATAN K3 (6k x 4k)
(11)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
GATAN ULTRASCAN 4000 (4k x 4k)
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 47
Entries 1 to 10 of 47
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Human TFIID BC core
Patel AB, Louder RK, Greber BJ, Grunberg S, Luo J, Fang J, Liu Y, Ranish J, Hahn S, Nogales E
Science (2018) [PMID: 30442764  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-126217 (Preferred)   search this ID
PDBe-KB: Q12962    O00268    Q6P1X5    P49848    Q16514    Q15542    (view 2 more)
Electron Microscopy
4.5Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
Data not analysed
6mzc
6mzc
6mzc
Human TFIID bound to promoter DNA and TFIIA
Patel AB, Louder RK, Greber BJ, Grunberg S, Luo J, Fang J, Liu Y, Ranish J, Hahn S, Nogales E
Science (2018) [PMID: 30442764  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: General transcription factor complex TFIIA and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-120309 (Preferred)   search this ID
PDBe-KB: Q12962    P21675    O00268    P20226    P52655    Q6P1X5    (view 7 more)
Electron Microscopy
7.5Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
Data not analysed
6mzm
6mzm
6mzm
p53-bound TFIID-based holo PIC on HDM2 promoter
Chen X, Wu Z, Hou H, Qi Y, Wang X, Li J, Xu Y
Science (2021) [PMID: 33795473  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279020 (Preferred)   search this ID
PDBe-KB: Q12962    Q13889    P19447    P21675    O00268    P20226    (view 36 more)
Electron Microscopy
3.9Å resolution
Released: 12 May 2021
Model geometry
Fit model/data
Data not analysed
7egc
7egc
7egc
TFIID in rearranged conformation
Chen X, Wu Z, Li J, Zhao D, Xu Y
Science (2021) [PMID: 33795473  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: General transcription factor complex TFIIA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126221 (Preferred)   search this ID
PDBe-KB: Q12962    P21675    O00268    P20226    P52655    Q6P1X5    (view 10 more)
Electron Microscopy
9.82Å resolution
Released: 12 May 2021
Model geometry
Fit model/data
Data not analysed
7egi
7egi
7egi
TFIID-based intermediate PIC on PUMA promoter
Chen X, Wu Z, Hou H, Qi Y, Wang X, Li J, Xu Y
Science (2021) [PMID: 33795473  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-236730 (Preferred)   search this ID
PDBe-KB: Q12962    P21675    O00268    P20226    P52655    A0A7M4DUC2    (view 27 more)
Electron Microscopy
4.1Å resolution
Released: 5 May 2021
Model geometry
Fit model/data
Data not analysed
7ega
7ega
7ega
TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)
Chen X, Qi Y, Wang X, Wu Z, Yin X, Li J, Liu W, Xu Y
Science (2021) [PMID: 33958484  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279019 (Preferred)   search this ID
PDBe-KB: Q12962    Q13889    P19447    P21675    O00268    P20226    (view 59 more)
Electron Microscopy
4.13Å resolution
Released: 26 May 2021
Model geometry
Fit model/data
Data not analysed
7enc
7enc
7enc
TFIID-based intermediate PIC on SCP promoter
Chen X, Qi Y, Wang X, Wu Z, Li J, Xu Y
Science (2021) [PMID: 33795473  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-236729 (Preferred)   search this ID
PDBe-KB: Q12962    P21675    O00268    P20226    P52655    A0A7M4DUC2    (view 27 more)
Electron Microscopy
3.7Å resolution
Released: 5 May 2021
Model geometry
Fit model/data
Data not analysed
7eg9
7eg9
7eg9
TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)
Chen X, Qi Y, Wang X, Wu Z, Yin X, Li J, Liu W, Xu Y
Science (2021) [PMID: 33958484  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-236785 (Preferred)   search this ID
PDBe-KB: Q12962    Q13889    P19447    P21675    O00268    P20226    (view 59 more)
Electron Microscopy
4.07Å resolution
Released: 26 May 2021
Model geometry
Fit model/data
Data not analysed
7ena
7ena
7ena
SET7/9 N265A in complex with AdoHcy and TAF10 peptide
Kroner GM, Fick RJ, Trievel RC
ACS Chem Biol (2016) [PMID: 26713889  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SAH    NA    SAH    NA   
Modified residues: MLZ    MLZ   
Assembly name: Histone-lysine N-methyltransferase SETD7 and Transcription initiation factor TFIID subunit 10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171459 (Preferred)   search this ID
PDBe-KB: Q12962    Q8WTS6   
X-ray diffraction
1.55Å resolution
Released: 13 Jan 2016
Model geometry
Fit model/data
5eg2
5eg2
5eg2
TFIID-based core PIC on SCP promoter
Chen X, Qi Y, Hou H, Wang X, Wu Z, Li J, Xu Y
Science (2021) [PMID: 33795473  ]
Source organisms: Sus scrofa  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: General transcription factor TFIIF complex and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275675 (Preferred)   search this ID
PDBe-KB: Q12962    P21675    O00268    P20226    P52655    A0A7M4DUC2    (view 25 more)
Electron Microscopy
6.2Å resolution
Released: 5 May 2021
Model geometry
Fit model/data
Data not analysed
7eg7
7eg7
7eg7
Entries 1 to 10 of 47
Entries 1 to 10 of 47