Uniprot accession / id : Q8R480  OR   Uniprot accession / id : Q9BW27  OR   Uniprot accession / id : J3KS87
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
Electron Microscopy
(4)
 
Authors  (47)
Beck M
(3)
Buczak K
(3)
Kosinski J
(3)
Mackmull MT
(3)
Mosalaganti S
(3)
Hagen WJH
(2)
Hummer G
(2)
Margiotta E
(2)
Obarska-Kosinska A
(2)
Schmidt FH
(2)
Siggel M
(2)
Taniguchi R
(2)
Turonova B
(2)
Turoňová B
(2)
Zimmerli CE
(2)
Andres-Pons A
(1)
Antonin W
(1)
Banterle N
(1)
Bork P
(1)
Brignole EJ
(1)
Bui KH
(1)
Dasso M
(1)
DiGuilio A
(1)
DiGuilio AL
(1)
Diguilio A
(1)
Dip PV
(1)
Glavy JS
(1)
Hagen W
(1)
Kastritis P
(1)
Kronenberg-Tenga R
(1)
Lemke EA
(1)
Lytton-Jean AKR
(1)
Mackmull M
(1)
Mankus D
(1)
Medalia O
(1)
Ori A
(1)
Parca L
(1)
Regmi SG
(1)
Schuller AP
(1)
Schwartz TU
(1)
Sparks L
(1)
Tatli M
(1)
Vollmer B
(1)
Von Appen A
(1)
Weis K
(1)
Wojtynek M
(1)
von Appen A
(1)
 
Homo / hetero assembly  (1)
hetero
(4)
 
Assembly composition  (1)
protein/protein complex
(4)
 
Assembly polymer count  (3)
808-mer
(2)
288-mer
(1)
304-mer
(1)
 
Resolution distribution
11.5 - 12
(1)
22.5 - 23
(1)
34.5 - 35
(1)
49.5 - 50
(1)
 
Release year distribution
2010 - 2015
(1)
2015 - 2020
(1)
2020 - 2025
(3)
 
Journal  (2)
Nature
(2)
Science
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (6)
85 kDa nucleoporin
(4)
FROUNT
(4)
Nuclear pore complex protein Nup85
(4)
Nucleoporin Nup75
(4)
Nucleoporin Nup85
(4)
Pericentrin-1
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (3)
NUP75
(4)
NUP85
(4)
PCNT1
(4)
 
Interacting Molecules  (24)
Nuclear pore complex protein Nup107
(4)
Nuclear pore complex protein Nup133
(4)
Nuclear pore complex protein Nup160
(4)
Nuclear pore complex protein Nup96
(4)
Nucleoporin Nup37
(4)
Nucleoporin Nup43
(4)
Nucleoporin SEH1
(4)
Protein SEC13 homolog
(4)
Nuclear pore complex protein Nup155
(3)
Aladin
(2)
E3 SUMO-protein ligase RanBP2
(2)
Nuclear pore complex protein Nup205
(2)
Nuclear pore complex protein Nup214
(2)
Nuclear pore complex protein Nup88
(2)
Nuclear pore complex protein Nup93
(2)
Nuclear pore complex protein Nup98
(2)
Nuclear pore glycoprotein p62
(2)
Nuclear pore membrane glycoprotein 210
(2)
Nucleoporin NDC1
(2)
Nucleoporin NUP188
(2)
Nucleoporin NUP35
(2)
Nucleoporin p54
(2)
Nucleoporin p58/p45
(2)
Protein ELYS
(2)
 
Function and Biology
Biological function  (2)
protein binding
(4)
structural constituent of nuclear pore
(4)
 
Biological process  (10)
chemotaxis
(4)
lamellipodium assembly
(4)
mRNA export from nucleus
(4)
mRNA transport
(4)
macrophage chemotaxis
(4)
nephron development
(4)
nucleocytoplasmic transport
(4)
positive regulation of DNA-templated transcription
(4)
protein import into nucleus
(4)
protein transport
(4)
 
Biological cell component  (17)
actin cytoskeleton
(4)
chromosome
(4)
chromosome, centromeric region
(4)
ciliary basal body
(4)
cytoplasm
(4)
cytoskeleton
(4)
cytosol
(4)
intracellular membrane-bounded organelle
(4)
kinetochore
(4)
membrane
(4)
nuclear envelope
(4)
nuclear membrane
(4)
nuclear pore
(4)
nuclear pore outer ring
(4)
nucleoplasm
(4)
nucleus
(4)
spindle
(4)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF07575 : Nucleopor_Nup85
(4)
 
Experimental Information
EM microscope model  (2)
FEI TITAN KRIOS
(2)
TFS KRIOS
(2)
 
EM detector name  (3)
GATAN K2 QUANTUM (4k x 4k)
(2)
GATAN K2 (4k x 4k)
(1)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Model of the outer rings of the human nuclear pore complex
Schuller AP, Wojtynek M, Mankus D, Tatli M, Kronenberg-Tenga R, Regmi SG, Dasso M, Weis K, Medalia O, Schwartz TU
Nature (2021) [PMID: 34646014  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-156686 (Preferred)   search this ID
PDBe-KB: Q9BW27    Q8NFH3    P55735    Q12769    P57740    Q96EE3    (view 3 more)
Electron Microscopy
35Å resolution
Released: 20 Oct 2021
Model geometry
Fit model/data
Data not analysed
7peq
7peq
7peq
Human nuclear pore complex
von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio A, Vollmer B, Mackmull M, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
Nature (2015) [PMID: 26416747  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-131100 (Preferred)   search this ID
PDBe-KB: Q9BW27    Q8NFH3    Q12769    P55735    P57740    Q8NFH4    (view 4 more)
Electron Microscopy
23Å resolution
Released: 30 Sep 2015
Model geometry
Fit model/data
Data not analysed
5a9q
5a9q
5a9q
Human nuclear pore complex (constricted)
Mosalaganti S, Obarska-Kosinska A, Siggel M, Taniguchi R, Turonova B, Zimmerli CE, Buczak K, Schmidt FH, Margiotta E, Mackmull MT, Hagen WJH, Hummer G, Kosinski J, Beck M
Science (2022) [PMID: 35679397  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-131102 (Preferred)   search this ID
PDBe-KB: Q9BW27    P49792    Q9BVL2    Q8NFH3    Q8N1F7    P37198    (view 18 more)
Electron Microscopy
12Å resolution
Released: 22 Jun 2022
Model geometry
Fit model/data
Data not analysed
7r5k
7r5k
7r5k
Human nuclear pore complex (dilated)
Mosalaganti S, Obarska-Kosinska A, Siggel M, Taniguchi R, Turonova B, Zimmerli CE, Buczak K, Schmidt FH, Margiotta E, Mackmull MT, Hagen WJH, Hummer G, Kosinski J, Beck M
Science (2022) [PMID: 35679397  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-131102 (Preferred)   search this ID
PDBe-KB: Q9BW27    P49792    Q9BVL2    Q8NFH3    Q8N1F7    P37198    (view 18 more)
Electron Microscopy
50Å resolution
Released: 21 Sep 2022
Model geometry
Fit model/data
Data not analysed
7r5j
7r5j
7r5j
Entries 1 to 4 of 4
Entries 1 to 4 of 4