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Entry status
(1)
Experimental methods
(2)
Electron Microscopy
(1)
Solution NMR
(1)
Authors
(16)
Arrowsmith CH
(1)
Baek K
(1)
Doherty R
(1)
Duan S
(1)
Ho M
(1)
Hopf LVM
(1)
Kaustov L
(1)
Klugel M
(1)
Klügel M
(1)
Lemak A
(1)
Lukin J
(1)
Northeast Structural Genomics Consortium (NESG)
(1)
Penn LZ
(1)
Schulman BA
(1)
Xiong Y
(1)
von Gronau S
(1)
Homo / hetero assembly
(2)
hetero
(1)
homo
(1)
Assembly composition
(2)
protein structure
(1)
protein/protein complex
(1)
Assembly polymer count
(2)
monomer
(1)
tetramer
(1)
Resolution distribution
2.5 - 3
(1)
Release year distribution
2005 - 2010
(1)
2020 - 2025
(1)
Journal
(2)
J Biol Chem
(1)
Nat Struct Mol Biol
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(2)
Organism name
(1)
Homo sapiens
(2)
Molecule name
(2)
CUL-7
(2)
Cullin-7
(2)
Molecule type
(1)
Protein
(2)
Gene names
(2)
CUL7
(2)
KIAA0076
(2)
Interacting Molecules
(3)
E3 ubiquitin-protein ligase RBX1
(1)
F-box/WD repeat-containing protein 8
(1)
S-phase kinase-associated protein 1
(1)
Function and Biology
Biological function
(3)
protein binding
(1)
ubiquitin ligase complex scaffold activity
(1)
ubiquitin protein ligase binding
(1)
Biological process
(12)
Golgi organization
(1)
epithelial to mesenchymal transition
(1)
microtubule cytoskeleton organization
(1)
mitotic cytokinesis
(1)
negative regulation of insulin receptor signaling pathway
(1)
placenta development
(1)
positive regulation of dendrite morphogenesis
(1)
protein ubiquitination
(1)
proteolysis
(1)
regulation of mitotic nuclear division
(1)
ubiquitin-dependent protein catabolic process
(1)
vasculogenesis
(1)
Biological cell component
(10)
3M complex
(1)
Cul7-RING ubiquitin ligase complex
(1)
Golgi apparatus
(1)
anaphase-promoting complex
(1)
centrosome
(1)
cullin-RING ubiquitin ligase complex
(1)
cytoplasm
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cytoskeleton
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cytosol
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perinuclear region of cytoplasm
(1)
Sequence and Structure classification
SCOP fold
(1)
SH3-like barrel
(1)
SCOP family
(1)
CPH domain
(1)
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Mainly Beta
(1)
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(1)
SH3 type barrels.
(1)
Pfam accession / name
(3)
PF11515 : Cul7
(2)
PF00888 : Cullin
(1)
PF03256 : ANAPC10
(1)
Experimental Information
Diffraction protocol
(1)
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(1)
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FEI TITAN KRIOS
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NMR
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(4)
CNS
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NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(1)
600.0 - 700
(1)
Representative Structures
Representative Structures
Entries
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Entries 1 to 2 of 2
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Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.
Lemak A, Kaustov L, Lukin J, Duan S, Arrowsmith CH, Northeast Structural Genomics Consortium (NESG)
J Biol Chem
(2007)
[PMID: 17298945 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Cullin-7
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172137 (Preferred)
search this ID

Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Hopf LVM, Schulman BA
Nat Struct Mol Biol
(2022)
[PMID: 35982156 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-158745 (Preferred)
search this ID
Entries 1 to 2 of 2