Entry status  (1)

REL

(10)

Experimental methods  (1)

X-ray diffraction

(10)

Authors  (20)

Chen Y

(7)

Gadi RK

(7)

Ghosh AK

(7)

Sonawane A

(7)

Tesmer JJG

(7)

Gamage SP

(5)

Tesmer JG

(5)

Benovic JL

(3)

Bhardwaj A

(3)

Komolov KE

(3)

Manda R

(2)

Chung KY

(1)

Dror RO

(1)

Duc NM

(1)

Laurinavichyute DK

(1)

Lou HJ

(1)

Sulon S

(1)

Sulon SM

(1)

Turk BE

(1)

van Keulen SC

(1)

Homo / hetero assembly  (2)

homo

(9)

hetero

(1)

Assembly composition  (2)

protein structure

(9)

protein/protein complex

(1)

Assembly polymer count  (2)

monomer

(9)

dimer

(1)

Resolution distribution

1.5 - 2

(2)

2.0 - 2.5

(2)

2.5 - 3

(5)

3.5 - 4

(1)

Release year distribution

2010 - 2015

(2)

2015 - 2020

(3)

2020 - 2025

(8)

2025 - 2030

(5)

Journal  (3)

Eur J Med Chem

(7)

J Biol Chem

(2)

Mol Cell

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (1)

Homo sapiens

(10)

Molecule name  (2)

G protein-coupled receptor kinase 5

(10)

G protein-coupled receptor kinase GRK5

(10)

Molecule type  (1)

Protein

(10)

Gene names  (2)

GPRK5

(10)

GRK5

(10)

Interacting Molecules  (1)

EF-hand domain-containing protein

(1)

Interacting ligands  (9)

SGV : SANGIVAMYCIN

(2)

W3F : (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide

(2)

A1AQ6 : (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-2-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide

(1)

A1AQ7 : (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-3-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide

(1)

A1AQ8 : (3Z)-3-[(3,5-dimethyl-4-{[(2S)-5-oxooxolane-2-carbonyl]amino}-1H-pyrrol-2-yl)methylidene]-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide

(1)

A1AQ9 : (4S)-N-{5-[(Z)-(5-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-2,7-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl}-2-methylimidazo[1,2-a]pyridine-3-carboxamide

(1)

ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

(1)

MG : MAGNESIUM ION

(1)

W2T : (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide

(1)

EC number / name  (1)

2.7.11.16 : G-protein-coupled receptor kinase

(10)

Biological function  (12)

ATP binding

(10)

G protein-coupled receptor kinase activity

(10)

beta-adrenergic receptor kinase activity

(10)

kinase activity

(10)

lipid binding

(10)

nucleotide binding

(10)

phospholipid binding

(10)

protein binding

(10)

protein kinase C binding

(10)

protein kinase activity

(10)

protein serine/threonine kinase activity

(10)

transferase activity

(10)

Biological process  (14)

G protein-coupled receptor signaling pathway

(10)

Wnt signaling pathway

(10)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

(10)

apoptotic process

(10)

fat cell differentiation

(10)

negative regulation of apoptotic process

(10)

positive regulation of cell population proliferation

(10)

protein autophosphorylation

(10)

regulation of G protein-coupled receptor signaling pathway

(10)

regulation of cell cycle

(10)

regulation of signal transduction

(10)

tachykinin receptor signaling pathway

(10)

protein phosphorylation

(5)

signal transduction

(5)

Biological cell component  (7)

cytoplasm

(10)

cytosol

(10)

membrane

(10)

nuclear membrane

(10)

nuclear speck

(10)

nucleus

(10)

plasma membrane

(10)

CATH class  (2)

Alpha Beta

(2)

Mainly Alpha

(2)

CATH topology  (3)

Phosphorylase Kinase; domain 1

(2)

Regulator of G-protein Signalling 4; domain 2

(2)

Transferase(Phosphotransferase); domain 1

(2)

Pfam accession / name  (2)

PF00069 : Pkinase

(10)

PF00615 : RGS

(10)

Diffraction protocol  (1)

Single wavelength

(10)

Diffraction radiation source type  (2)

Synchrotron

(9)

Rotating anode

(1)

Diffraction source  (6)

NSLS-II BEAMLINE 17-ID-2

(3)

NSLS BEAMLINE X6A

(2)

NSLS-II BEAMLINE 17-ID-1

(2)

APS BEAMLINE 23-ID-B

(1)

APS BEAMLINE 23-ID-D

(1)

RIGAKU MICROMAX-007 HF

(1)

Synchrotron site  (3)

NSLS-II

(5)

APS

(2)

NSLS

(2)

Diffraction detector type  (2)

Pixel

(8)

CCD

(2)

Refinement software  (1)

PHENIX

(10)

Representative Structures

100%

95%

90%

70%

50%

40%

30%