Uniprot accession / id : Q921X6  OR   Uniprot accession / id : Q9H1D9
 
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Entry Information
Entry status  (1)
REL
(22)
 
Experimental methods  (2)
Electron Microscopy
(19)
Solution NMR
(3)
 
Authors  (58)
Misiaszek AD
(9)
Muller CW
(9)
Müller CW
(9)
Xu Y
(9)
Hou H
(7)
Ramsay EP
(6)
Vannini A
(6)
Cecatiello V
(5)
Graziadei A
(5)
Kaliyappan T
(5)
Perry TN
(5)
Ren Y
(5)
Shah SZ
(5)
Wang Q
(5)
Bateman A
(4)
Baudin F
(4)
Girbig M
(4)
Grotsch H
(4)
Grötsch H
(4)
Lafita A
(4)
Mueller CW
(4)
Vorlaender MK
(4)
Vorlander MK
(4)
Vorländer MK
(4)
Yu Z
(4)
Zhao D
(4)
Chen Z
(3)
He F
(3)
Inoue M
(3)
Jin Q
(3)
Kigawa T
(3)
Muto Y
(3)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(3)
Shirouzu M
(3)
Terada T
(3)
Yokoyama S
(3)
Cao M
(2)
Chen K
(2)
Lan P
(2)
Lei M
(2)
Li L
(2)
Li S
(2)
Li Y
(2)
Liu A
(2)
Wan F
(2)
Wang M
(2)
Wu J
(2)
Wu Z
(2)
Abascal-Palacios G
(1)
Beuron F
(1)
Daiss JL
(1)
Daiß JL
(1)
Engel C
(1)
Gouge J
(1)
Gunkel P
(1)
King H
(1)
Morris E
(1)
Pilsl M
(1)
 
Homo / hetero assembly  (2)
hetero
(19)
homo
(3)
 
Assembly composition  (4)
DNA/RNA/protein complex
(8)
DNA/protein complex
(8)
protein structure
(3)
protein/protein complex
(3)
 
Assembly polymer count  (4)
25-mer
(8)
icosamer
(8)
heptadecamer
(3)
monomer
(3)
 
Resolution distribution
2.5 - 3
(2)
3.0 - 3.5
(9)
3.5 - 4
(6)
4.0 - 4.5
(2)
 
Release year distribution
2005 - 2010
(3)
2015 - 2020
(1)
2020 - 2025
(19)
2025 - 2030
(5)
 
Journal  (4)
Nat Commun
(8)
Nat Struct Mol Biol
(6)
Cell Res
(5)
To be published
(3)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(22)
 
Organism name  (2)
Homo sapiens
(21)
Mus musculus
(1)
 
Molecule name  (5)
DNA-directed RNA polymerase III subunit F
(22)
DNA-directed RNA polymerase III subunit RPC6
(22)
RNA polymerase III subunit C6
(22)
RNA polymerase III 39 kDa subunit
(21)
RPC39
(21)
 
Molecule type  (1)
Protein
(22)
 
Gene names  (2)
POLR3F
(21)
Polr3f
(1)
 
Interacting Molecules  (44)
DNA-directed RNA polymerase III subunit RPC1
(19)
DNA-directed RNA polymerase III subunit RPC10
(19)
DNA-directed RNA polymerase III subunit RPC2
(19)
DNA-directed RNA polymerase III subunit RPC3
(19)
DNA-directed RNA polymerase III subunit RPC4
(19)
DNA-directed RNA polymerase III subunit RPC5
(19)
DNA-directed RNA polymerase III subunit RPC8
(19)
DNA-directed RNA polymerase III subunit RPC9
(19)
DNA-directed RNA polymerases I and III subunit RPAC1
(19)
DNA-directed RNA polymerases I and III subunit RPAC2
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC1
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC2
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC3
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC4
(19)
DNA-directed RNA polymerases I, II, and III subunit RPABC5
(19)
DNA-directed RNA polymerase III subunit RPC7
(18)
TATA-box-binding protein
(8)
Transcription factor IIIB 50 kDa subunit
(8)
Transcription factor TFIIIB component B'' homolog
(8)
snRNA-activating protein complex subunit 1
(8)
snRNA-activating protein complex subunit 3
(8)
snRNA-activating protein complex subunit 4
(8)
U6_2_Non template
(5)
U6_2_Template
(5)
Non-template DNA
(4)
RNA
(4)
Template DNA
(3)
RNA (5'-R(*CP*CP*GP*GP*GP*UP*GP*CP*UP*G)-3')
(2)
DNA (5'-D(P*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3')
(1)
DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3')
(1)
DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*T)-3')
(1)
DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3')
(1)
DNA (74-MER)
(1)
DNA (81-MER)
(1)
DNA (82-MER)
(1)
DNA-directed RNA polymerase III subunit RPC7-beta
(1)
Human gene for U 6 RNA
(1)
RNA (5'-R(P*AP*UP*C)-3')
(1)
RNA (5'-R(P*CP*CP*CP*GP*AP*U)-3')
(1)
Template-DNA
(1)
non-template DNA
(1)
non_template DNA
(1)
template
(1)
template DNA
(1)
 
Interacting ligands  (1)
SF4 : IRON/SULFUR CLUSTER
(18)
 
Function and Biology
EC number / name  (1)
2.7.7.6 : DNA-directed RNA polymerase
(2)
 
Biological function  (5)
4 iron, 4 sulfur cluster binding
(19)
DNA binding
(19)
DNA-directed RNA polymerase activity
(19)
double-stranded DNA binding
(19)
protein binding
(19)
 
Biological process  (7)
defense response to virus
(19)
immune system process
(19)
innate immune response
(19)
positive regulation of innate immune response
(19)
positive regulation of interferon-beta production
(19)
regulation of transcription by RNA polymerase III
(19)
transcription by RNA polymerase III
(17)
 
Biological cell component  (5)
RNA polymerase III complex
(22)
DNA-directed RNA polymerase complex
(19)
cytosol
(19)
nucleoplasm
(19)
nucleus
(19)
 
Sequence and Structure classification
SCOP fold  (1)
DNA/RNA-binding 3-helical bundle
(2)
 
SCOP family  (1)
RPO3F domain-like
(2)
 
CATH class  (1)
Mainly Alpha
(3)
 
CATH topology  (1)
Arc Repressor Mutant, subunit A
(3)
 
Pfam accession / name  (1)
PF05158 : RNA_pol_Rpc34
(19)
 
Experimental Information
Refinement software  (1)
PHENIX
(3)
 
EM microscope model  (1)
FEI TITAN KRIOS
(19)
 
EM detector name  (4)
GATAN K3 (6k x 4k)
(7)
GATAN K2 SUMMIT (4k x 4k)
(6)
TFS FALCON 4i (4k x 4k)
(5)
FEI FALCON III (4k x 4k)
(1)
 
NMR
NMR software packages  (5)
CYANA
(3)
KUJIRA
(3)
NMRPipe
(3)
NMRView
(3)
XwinNMR
(3)
 
NMR Field Strength
600.0 - 700
(1)
700.0 - 800
(3)
800.0 - 900
(2)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 22
Entries 1 to 10 of 22
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Solution structure of the domain swapped WingedHelix in DNA-directed RNA polymerase III 39 kDa polypeptide
He F, Muto Y, Inoue M, Kigawa T, Shirouzu M, Terada T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: DNA-directed RNA polymerase III subunit RPC6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-190513 (Preferred)   search this ID
PDBe-KB: Q9H1D9   
Solution NMR
Released: 9 Oct 2007
Model geometry
Fit model/data
Data not deposited
2yu3
2yu3
2yu3
Cryo-EM structure of human RNA Polymerase III elongation complex 3
Girbig M, Misiaszek AD, Vorlaender MK, Mueller CW
Nat Struct Mol Biol (2021) [PMID: 33558764  ]
Assembly composition: DNA/RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and RNA and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-121061 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P53803    P0DPB6    P61218    (view 11 more)
Electron Microscopy
3.1Å resolution
Released: 3 Feb 2021
Model geometry
Fit model/data
Data not analysed
7ae3
7ae3
7ae3
Cryo-EM structure of human RNA Polymerase III elongation complex 2
Girbig M, Misiaszek AD, Vorlaender MK, Mueller CW
Nat Struct Mol Biol (2021) [PMID: 33558764  ]
Assembly composition: DNA/RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and RNA and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-121062 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P53803    P0DPB6    P61218    (view 11 more)
Electron Microscopy
3.4Å resolution
Released: 3 Feb 2021
Model geometry
Fit model/data
Data not analysed
7aea
7aea
7aea
Apo Human RNA Polymerase III
Ramsay EP, Abascal-Palacios G, Daiss JL, King H, Gouge J, Pilsl M, Beuron F, Morris E, Gunkel P, Engel C, Vannini A
Nat Commun (2020) [PMID: 33335104  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-127154 (Preferred)   search this ID
PDBe-KB: Q9H1D9    P52434    O14802    P53803    P0DPB6    P61218    (view 10 more)
Electron Microscopy
4Å resolution
Released: 23 Dec 2020
Model geometry
Fit model/data
Data not analysed
7ast
7ast
7ast
human RNA polymerase III pre-initiation complex closed DNA 1
Hou H, Jin Q, Ren Y, Wang Q, Xu Y
Cell Res (2023) [PMID: 37165065  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-234931 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.9Å resolution
Released: 7 Jun 2023
Model geometry
Fit model/data
Data not analysed
8ity
8ity
8ity
RNA polymerase III pre-initiation complex open complex 1
Hou H, Jin Q, Ren Y, Wang Q, Xu Y
Cell Res (2023) [PMID: 37165065  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-216143 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.4Å resolution
Released: 24 May 2023
Model geometry
Fit model/data
Data not analysed
8iuh
8iuh
8iuh
Human RNA Polymerase III Class III Open Pre-initiation Complex 1 (OC1)
Shah SZ, Ramsay EP, Cecatiello V, Perry TN, Vannini A
Nat Commun (2025) [PMID: 39747245  ]
Source organisms: Homo  , Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283749 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.28Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
9fso
9fso
9fso
RNA Polymerase III Class III Open Mini Pre-initiation Complex 1 (OC1-mini)
Shah SZ, Ramsay EP, Cecatiello V, Perry TN, Vannini A
Nat Commun (2025) [PMID: 39747245  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283752 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.76Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
9fsr
9fsr
9fsr
RNA Polymerase III Class III Melting Pre-Initiation Complex (MC)
Shah SZ, Ramsay EP, Cecatiello V, Perry TN, Vannini A
Nat Commun (2025) [PMID: 39747245  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283751 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.51Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
9fsq
9fsq
9fsq
RNA Polymerase III Class III Open Pre-initation Complex 2 (OC2)
Shah SZ, Ramsay EP, Cecatiello V, Perry TN, Vannini A
Nat Commun (2025) [PMID: 39747245  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
Assembly name: DNA-directed RNA polymerase III complex, POLR3G variant and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283750 (Preferred)   search this ID
PDBe-KB: Q9H1D9    O14802    P52434    P20226    P53803    A6H8Y1    (view 17 more)
Electron Microscopy
3.39Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
9fsp
9fsp
9fsp
Entries 1 to 10 of 22
Entries 1 to 10 of 22