Uniprot accession / id : (Q99593)
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
X-ray diffraction
(4)
 
Authors  (14)
Ashur S
(2)
Gopal S
(2)
Grimm C
(2)
Kasahara H
(2)
Li S
(2)
Mueller CW
(2)
Muller CW
(2)
Müller CW
(2)
Nam HJ
(2)
Pradhan L
(2)
Ptchelkine D
(2)
Stirnimann CU
(2)
Suryanarayanan S
(2)
Patel A
(1)
 
Homo / hetero assembly  (2)
hetero
(2)
homo
(2)
 
Assembly composition  (2)
DNA/protein complex
(2)
protein structure
(2)
 
Assembly polymer count  (3)
tetramer
(2)
dimer
(1)
monomer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
2.5 - 3
(2)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(3)
2015 - 2020
(2)
 
Journal  (2)
Biochemistry
(2)
J Mol Biol
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (6)
T-box protein 5
(4)
T-box transcription factor TBX5
(4)
Cardiac-specific homeobox
(1)
Homeobox protein CSX
(1)
Homeobox protein NK-2 homolog E
(1)
Homeobox protein Nkx-2.5
(1)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (5)
TBX5
(4)
CSX
(1)
NKX2-5
(1)
NKX2.5
(1)
NKX2E
(1)
 
Interacting Molecules  (6)
5'-D(*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP*A)-3'
(1)
5'-D(*TP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP)-3'
(1)
5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP)-3'
(1)
5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP*TP*GP*AP*AP*GP*TP*GP*G)-3'
(1)
Homeobox protein Nkx-2.5
(1)
T-box transcription factor TBX5
(1)
 
Interacting ligands  (2)
PE4 : 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
(2)
MG : MAGNESIUM ION
(1)
 
Function and Biology
Biological function  (4)
DNA-binding transcription factor activity
(4)
RNA polymerase II cis-regulatory region sequence-specific DNA binding
(4)
DNA binding
(1)
DNA-binding transcription factor activity, RNA polymerase II-specific
(1)
 
Biological process  (2)
positive regulation of DNA-templated transcription
(4)
regulation of DNA-templated transcription
(4)
 
Biological cell component  (1)
nucleus
(4)
 
Sequence and Structure classification
CATH class  (2)
Mainly Beta
(4)
Mainly Alpha
(1)
 
CATH topology  (2)
Immunoglobulin-like
(4)
Arc Repressor Mutant, subunit A
(1)
 
Pfam accession / name  (2)
PF00907 : T-box
(4)
PF00046 : Homeodomain
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
CHESS BEAMLINE A1
(2)
ESRF BEAMLINE ID14-1
(1)
ESRF BEAMLINE ID23-2
(1)
 
Synchrotron site  (2)
CHESS
(2)
ESRF
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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TBX5 DB, NKX2.5 HD, ANF DNA Complex
Pradhan L
Biochemistry (2016) [PMID: 26926761  ]
Assembly composition: DNA/protein complex
Assembly name: Homeobox protein Nkx-2.5 and T-box transcription factor TBX5 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118156 (Preferred)   search this ID
PDBe-KB: P52952    Q99593   
X-ray diffraction
2.817Å resolution
Released: 16 Dec 2015
Model geometry
Fit model/data
4s0h
4s0h
4s0h
Crystal Structure of TBX5 (1-239) Dimer
Pradhan L, Gopal S, Patel A, Kasahara H, Nam HJ
Biochemistry (2016) [PMID: 26926761  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    MG   
Assembly name: T-box transcription factor TBX5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189229 (Preferred)   search this ID
PDBe-KB: Q99593   
X-ray diffraction
2.583Å resolution
Released: 16 Mar 2016
Model geometry
Fit model/data
5bqd
5bqd
5bqd
Crystal structure of human TBX5 in the DNA-free form
Stirnimann CU, Mueller CW
J Mol Biol (2010) [PMID: 20450920  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    PE4    PE4    MG   
Assembly name: T-box transcription factor TBX5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189228 (Preferred)   search this ID
PDBe-KB: Q99593   
X-ray diffraction
1.9Å resolution
Released: 28 Apr 2010
Model geometry
Fit model/data
2x6u
2x6u
2x6u
Crystal structure of human TBX5 in the DNA-bound and DNA-free form
Ptchelkine D, Stirnimann CU, Grimm C, Mueller CW
J Mol Biol (2010) [PMID: 20450920  ]
Assembly composition: DNA/protein complex
Bound ligands: MG    PE4    PE4    MG   
Assembly name: T-box transcription factor TBX5 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-115919 (Preferred)   search this ID
PDBe-KB: Q99593   
X-ray diffraction
2.2Å resolution
Released: 28 Apr 2010
Model geometry
Fit model/data
2x6v
2x6v
2x6v
Entries 1 to 4 of 4
Entries 1 to 4 of 4