Uniprot accession / id : Q9D0J4  OR   Uniprot accession / id : P36404
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (1)
X-ray diffraction
(6)
 
Authors  (19)
Wittinghofer A
(4)
Hanzal-Bayer M
(3)
Hillig RC
(3)
Renault L
(3)
Roversi P
(3)
Ding J
(2)
Lai Z
(2)
Li S
(2)
Zhang T
(2)
Zhang Y
(2)
Zhong C
(2)
Chen YX
(1)
Ismail S
(1)
Ismail SA
(1)
Koerner C
(1)
Miertzschke M
(1)
Vetter I
(1)
Vetter IR
(1)
Xiang-Chen Y
(1)
 
Homo / hetero assembly  (1)
hetero
(6)
 
Assembly composition  (1)
protein/protein complex
(6)
 
Assembly polymer count  (1)
dimer
(6)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(2)
2.5 - 3
(2)
3.0 - 3.5
(1)
 
Release year distribution
2000 - 2005
(3)
2005 - 2010
(2)
2010 - 2015
(1)
 
Journal  (2)
EMBO J
(4)
Structure
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (2)
Mus musculus
(4)
Homo sapiens
(2)
 
Molecule name  (1)
ADP-ribosylation factor-like protein 2
(6)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (2)
Arl2
(4)
ARL2
(2)
 
Interacting Molecules  (3)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(3)
ADP-ribosylation factor-like protein 2-binding protein
(2)
Protein unc-119 homolog A
(1)
 
Interacting ligands  (6)
MG : MAGNESIUM ION
(6)
GTP : GUANOSINE-5'-TRIPHOSPHATE
(4)
GDP : GUANOSINE-5'-DIPHOSPHATE
(2)
PO4 : PHOSPHATE ION
(2)
BME : BETA-MERCAPTOETHANOL
(1)
GNP : PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
(1)
 
Function and Biology
Biological function  (5)
GDP binding
(6)
GTP binding
(6)
GTPase activity
(6)
nucleotide binding
(6)
protein binding
(6)
 
Biological process  (10)
bicellular tight junction assembly
(6)
centrosome cycle
(6)
maintenance of protein location in nucleus
(6)
negative regulation of GTPase activity
(6)
positive regulation of cell-substrate adhesion
(6)
positive regulation of microtubule polymerization
(6)
regulation of aerobic respiration
(6)
regulation of glycolytic process
(6)
regulation of microtubule polymerization
(6)
protein folding
(2)
 
Biological cell component  (14)
centrosome
(6)
ciliary basal body
(6)
cytoplasm
(6)
cytoskeleton
(6)
lateral plasma membrane
(6)
mitochondrial intermembrane space
(6)
mitochondrion
(6)
nucleolus
(6)
nucleoplasm
(6)
nucleus
(6)
cilium
(2)
cytosol
(2)
microtubule cytoskeleton
(2)
mitochondrial matrix
(2)
 
Sequence and Structure classification
SCOP fold  (1)
P-loop containing nucleoside triphosphate hydrolases
(3)
 
SCOP family  (1)
G proteins
(3)
 
CATH class  (1)
Alpha Beta
(6)
 
CATH topology  (1)
Rossmann fold
(6)
 
Pfam accession / name  (1)
PF00025 : Arf
(6)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (1)
Synchrotron
(6)
 
Diffraction source  (5)
ESRF BEAMLINE ID13
(2)
MPG/DESY, HAMBURG BEAMLINE BW6
(1)
PHOTON FACTORY BEAMLINE BL-5A
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (4)
ESRF
(2)
Photon Factory
(2)
MPG/DESY, HAMBURG
(1)
SLS
(1)
 
Diffraction detector type  (1)
CCD
(6)
 
Refinement software  (4)
REFMAC
(3)
CNS
(2)
BETA
(1)
BUSTER
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Complex of ARL2 and BART, Crystal Form 2
Zhang T, Li S, Ding J
Structure (2009) [PMID: 19368893  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    GTP    GTP    MG   
Assembly name: ADP-ribosylation factor-like protein 2 and ADP-ribosylation factor-like protein 2-binding protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153183 (Preferred)   search this ID
PDBe-KB: P36404    Q9Y2Y0   
X-ray diffraction
3.3Å resolution
Released: 3 Mar 2009
Model geometry
Fit model/data
3dof
3dof
3dof
Complex of Arl2 and PDE delta, Crystal Form 2 (native)
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC
EMBO J (2002) [PMID: 11980706  ]
Assembly composition: protein/protein complex
Bound ligands: GDP    MG    GDP    MG    PO4   
Modified residues: CME    CME   
Assembly name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta and ADP-ribosylation factor-like protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-129180 (Preferred)   search this ID
PDBe-KB: Q9D0J4    O43924   
X-ray diffraction
1.8Å resolution
Released: 8 May 2002
Model geometry
Fit model/data
1ksh
1ksh
1ksh
Complex of Arl2 and PDE delta, Crystal Form 1
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC
EMBO J (2002) [PMID: 11980706  ]
Assembly composition: protein/protein complex
Bound ligands: MG    GTP    GTP    MG   
Assembly name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta and ADP-ribosylation factor-like protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-129180 (Preferred)   search this ID
PDBe-KB: Q9D0J4    O43924   
X-ray diffraction
2.3Å resolution
Released: 8 May 2002
Model geometry
Fit model/data
1ksg
1ksg
1ksg
The Crystal structure of Arl2GppNHp in complex with UNC119a
Ismail S, Xiang-Chen Y, Miertzschke M, Vetter I, Koerner C, Wittinghofer A
EMBO J (2012) [PMID: 22960633  ]
Assembly composition: protein/protein complex
Bound ligands: GNP    MG    GNP    MG   
Assembly name: Protein unc-119 homolog A and ADP-ribosylation factor-like protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171688 (Preferred)   search this ID
PDBe-KB: Q9D0J4    Q13432   
X-ray diffraction
2.6Å resolution
Released: 19 Sep 2012
Model geometry
Fit model/data
4gok
4gok
4gok
Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet)
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC
EMBO J (2002) [PMID: 11980706  ]
Assembly composition: protein/protein complex
Bound ligands: GDP    MG    BME    GTP    GDP    GTP    MG    PO4   
Modified residues: MSE    MSE    CME    CME   
Assembly name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta and ADP-ribosylation factor-like protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-129180 (Preferred)   search this ID
PDBe-KB: Q9D0J4    O43924   
X-ray diffraction
2.6Å resolution
Released: 8 May 2002
Model geometry
Fit model/data
1ksj
1ksj
1ksj
Complex of ARL2 and BART, Crystal Form 1
Zhang T, Li S, Ding J
Structure (2009) [PMID: 19368893  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    GTP    GTP    MG   
Assembly name: ADP-ribosylation factor-like protein 2 and ADP-ribosylation factor-like protein 2-binding protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153183 (Preferred)   search this ID
PDBe-KB: P36404    Q9Y2Y0   
X-ray diffraction
2.25Å resolution
Released: 3 Mar 2009
Model geometry
Fit model/data
3doe
3doe
3doe
Entries 1 to 6 of 6
Entries 1 to 6 of 6