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Entry status
(1)
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(2)
Solution NMR
(3)
X-ray diffraction
(1)
Authors
(37)
Gehring K
(2)
Jeon YH
(2)
Kozlov G
(2)
Lee C
(2)
Banville D
(1)
Cheng J
(1)
Cheong C
(1)
Cho JM
(1)
Ekiel I
(1)
Gulerez I
(1)
Jee J
(1)
Jeong K
(1)
Jeong KW
(1)
Jin B
(1)
Kang D
(1)
Kang DI
(1)
Kim E
(1)
Kim EE
(1)
Kim EH
(1)
Kim J
(1)
Kim KA
(1)
Kim Y
(1)
Lee CK
(1)
Lee E
(1)
Lee TG
(1)
Lee W
(1)
Li X
(1)
Park YG
(1)
Ro S
(1)
Sheen MR
(1)
Shin A
(1)
Shin S
(1)
Song JS
(1)
Wu H
(1)
Yamazaki T
(1)
Zhang H
(1)
Ziomek E
(1)
Homo / hetero assembly
(2)
homo
(3)
hetero
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Assembly composition
(2)
protein structure
(3)
protein/protein complex
(1)
Assembly polymer count
(2)
monomer
(3)
tetramer
(1)
Resolution distribution
3.0 - 3.5
(1)
Release year distribution
2000 - 2005
(2)
2010 - 2015
(1)
2015 - 2020
(1)
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(4)
Biochemistry
(1)
FEBS Lett
(1)
J Biol Chem
(1)
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Macromolecules
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(1)
Eukaryota
(4)
Organism name
(1)
Homo sapiens
(4)
Molecule name
(5)
PRL-3
(4)
PRL-R
(4)
Protein tyrosine phosphatase type IVA 3
(4)
Protein-tyrosine phosphatase 4a3
(4)
Protein-tyrosine phosphatase of regenerating liver 3
(4)
Molecule type
(1)
Protein
(4)
Gene names
(2)
PRL3
(4)
PTP4A3
(4)
Interacting Molecules
(1)
Metal transporter CNNM3
(1)
Function and Biology
EC number / name
(1)
3.1.3.48 : Protein-tyrosine-phosphatase
(4)
Biological function
(4)
hydrolase activity
(4)
phosphoprotein phosphatase activity
(4)
protein binding
(4)
protein tyrosine phosphatase activity
(4)
Biological process
(10)
Notch signaling pathway
(4)
cellular response to leukemia inhibitory factor
(4)
dephosphorylation
(4)
endothelial cell migration
(4)
positive regulation of establishment of protein localization
(4)
positive regulation of non-canonical NF-kappaB signal transduction
(4)
positive regulation of vascular permeability
(4)
protein dephosphorylation
(4)
regulation of DNA-templated transcription
(4)
regulation of vascular endothelial growth factor signaling pathway
(4)
Biological cell component
(6)
cytoplasm
(4)
early endosome
(4)
endosome
(4)
membrane
(4)
nucleus
(4)
plasma membrane
(4)
Sequence and Structure classification
SCOP fold
(1)
(Phosphotyrosine protein) phosphatases II
(2)
SCOP family
(1)
Dual specificity phosphatase-like
(2)
CATH class
(1)
Alpha Beta
(4)
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Protein-Tyrosine Phosphatase; Chain A
(4)
Pfam accession / name
(1)
PF22785 : Tc-R-P
(4)
Experimental Information
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(3)
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NMR software packages
(7)
ARIA
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CYANA
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Gifa
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Xplor-NIH
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XwinNMR
(1)
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(2)
600.0 - 700
(1)
700.0 - 800
(2)
800.0 - 900
(2)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
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Entries 1 to 4 of 4
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Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter
Kozlov G, Zhang H, Gehring K
Sci Rep
(2017)
[PMID: 28246390 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Protein tyrosine phosphatase type IVA 3 and Metal transporter CNNM3
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130913 (Preferred)
search this ID
Structure of human PRL-3, the phosphatase associated with cancer metastasis
Jeon YH, Cheong C
FEBS Lett
(2004)
[PMID: 15135076 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Protein tyrosine phosphatase type IVA 3
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130912 (Preferred)
search this ID

Solution Structure of human holo-PRL-3 in complex with vanadate
Jeong K, Kang D, Kim J, Shin S, Jin B, Lee C, Kim E, Jeon YH, Kim Y
Biochemistry
(2014)
[PMID: 24983822 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Protein tyrosine phosphatase type IVA 3
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130912 (Preferred)
search this ID

Solution Structure of human PRL-3
Kozlov G, Gehring K, Ekiel I
J Biol Chem
(2004)
[PMID: 14704153 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Protein tyrosine phosphatase type IVA 3
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130912 (Preferred)
search this ID

Entries 1 to 4 of 4