Entry status  (1)

REL

(13)

Experimental methods  (1)

X-ray diffraction

(13)

Authors  (73)

Chen L

(6)

Esaki S

(6)

Fu R

(6)

Liu A

(6)

Liu F

(6)

Rehmani I

(6)

Serrano V

(6)

de Serrano V

(6)

Ali S

(3)

Burke R

(3)

Cheeseman MD

(3)

Esaka S

(3)

Evans LE

(3)

Jones K

(3)

O'Fee L

(3)

Pasqua AE

(3)

Rowlands M

(3)

Rye CS

(3)

Tucker MJ

(3)

Wilding B

(3)

Workman P

(3)

Blagg J

(2)

Brown N

(2)

Campbell PL

(2)

Carter M

(2)

Chessum NEA

(2)

Dexheimer TS

(2)

Fox DA

(2)

Gopallawa I

(2)

Haynes SE

(2)

Jin X

(2)

Kahl D

(2)

Khanna D

(2)

Larsen SD

(2)

Le Bihan YV

(2)

Lisabeth EM

(2)

Martin BR

(2)

Meyers J

(2)

Misek SA

(2)

Mok NY

(2)

Neubig R

(2)

Neubig RR

(2)

Wilson DW

(2)

van Montfort RLM

(2)

Bartlam M

(1)

Chessum NE

(1)

De Billy E

(1)

Eccles SA

(1)

Gao GF

(1)

Hayes A

(1)

Henley AT

(1)

Hisano T

(1)

Lepri S

(1)

Miah A

(1)

Miki K

(1)

Miyatake H

(1)

Miyazaki I

(1)

Okumura H

(1)

Osada H

(1)

Pang H

(1)

Pellegrino L

(1)

Powers M

(1)

Rao Z

(1)

Raynaud F

(1)

Richards M

(1)

Sharp SY

(1)

Simizu S

(1)

Takagi S

(1)

Te Poele R

(1)

Wong LL

(1)

Zeng Q

(1)

van Montfort R

(1)

van Montfort RL

(1)

Homo / hetero assembly  (1)

homo

(13)

Assembly composition  (1)

protein structure

(13)

Assembly polymer count  (1)

monomer

(13)

Resolution distribution

1.0 - 1.5

(1)

1.5 - 2

(7)

2.0 - 2.5

(4)

2.5 - 3

(1)

Release year distribution

2000 - 2005

(1)

2005 - 2010

(1)

2010 - 2015

(7)

2015 - 2020

(5)

Journal  (6)

Proc Natl Acad Sci U S A

(6)

ACS Med Chem Lett

(2)

ACS Pharmacol Transl Sci

(2)

J Biol Chem

(1)

J Med Chem

(1)

Nat Chem Biol

(1)

Organism superkingdom  (1)

Eukaryota

(13)

Organism name  (1)

Homo sapiens

(13)

Molecule name  (3)

Pirin

(13)

Probable quercetin 2,3-dioxygenase PIR

(13)

Probable quercetinase

(13)

Molecule type  (1)

Protein

(13)

Gene names  (1)

PIR

(13)

Interacting ligands  (13)

FE : FE (III) ION

(7)

EDO : 1,2-ETHANEDIOL

(5)

FE2 : FE (II) ION

(3)

GOL : GLYCEROL

(3)

MN : MANGANESE (II) ION

(2)

3F1 : N-{[4-(benzyloxy)phenyl](methyl)-lambda~4~-sulfanylidene}-4-methylbenzenesulfonamide

(1)

6JQ : N-{5-[(2,3-dihydro-1,4-benzodioxine-6-carbonyl)amino]-2-methylphenyl}-2-[3-(pyrrolidin-1-yl)propyl]quinoline-6-carboxamide

(1)

CO : COBALT (II) ION

(1)

DMS : DIMETHYL SULFOXIDE

(1)

FJE : [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)methanone

(1)

FJH : ~{N}-[5-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonylamino)-2-methyl-phenyl]-2-methyl-quinoline-6-carboxamide

(1)

K8M : (3R)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyridin-4-yl)benzene-1-carbonyl]piperidine-3-carboxamide

(1)

K8S : (3S)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzene-1-carbonyl]piperidine-3-carboxamide

(1)

EC number / name  (1)

1.13.11.24 : Quercetin 2,3-dioxygenase

(13)

Biological function  (6)

dioxygenase activity

(13)

metal ion binding

(13)

oxidoreductase activity

(13)

protein binding

(13)

quercetin 2,3-dioxygenase activity

(13)

transcription coregulator activity

(13)

Biological process  (4)

digestion

(13)

monocyte differentiation

(13)

myeloid cell differentiation

(13)

transcription by RNA polymerase II

(13)

Biological cell component  (5)

cytoplasm

(13)

cytosol

(13)

nuclear body

(13)

nucleoplasm

(13)

nucleus

(13)

SCOP fold  (1)

Double-stranded beta-helix

(1)

SCOP family  (1)

Pirin-like

(1)

CATH class  (1)

Mainly Beta

(11)

CATH topology  (1)

Jelly Rolls

(11)

Pfam accession / name  (2)

PF02678 : Pirin

(13)

PF05726 : Pirin_C

(13)

Diffraction protocol  (2)

Single wavelength

(12)

MAD

(1)

Diffraction radiation source type  (2)

Synchrotron

(10)

Rotating anode

(3)

Diffraction source  (9)

APS BEAMLINE 22-ID

(3)

ESRF BEAMLINE MASSIF-1

(2)

RIGAKU MICROMAX-007

(2)

APS BEAMLINE 21-ID-D

(1)

APS BEAMLINE 21-ID-G

(1)

ESRF BEAMLINE ID23-2

(1)

RIGAKU RU300

(1)

SPRING-8 BEAMLINE BL26B2

(1)

SPRING-8 BEAMLINE BL44B2

(1)

Synchrotron site  (3)

APS

(5)

ESRF

(3)

SPring-8

(2)

Diffraction detector type  (3)

CCD

(9)

Pixel

(3)

Image plate

(1)

Refinement software  (4)

REFMAC

(5)

BUSTER

(3)

PHENIX

(3)

CNS

(2)

Representative Structures

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