Uniprot accession / id : Q9D7N6  OR   Uniprot accession / id : Q8TCC3
 
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Entry Information
Entry status  (1)
REL
(69)
 
Experimental methods  (1)
Electron Microscopy
(69)
 
Authors  (164)
Amunts A
(20)
Beckmann R
(15)
Cheng J
(15)
Aibara S
(14)
Singh V
(13)
Ramakrishnan V
(11)
Minczuk M
(10)
Berninghausen O
(9)
Modelska A
(9)
Rorbach J
(9)
Li X
(8)
Bohnsack KE
(7)
Chandrasekaran V
(7)
Desai N
(7)
Hanitsch E
(7)
Hillen HS
(7)
Itoh Y
(7)
Lavdovskaia E
(7)
Linden A
(7)
Nadler F
(7)
Richter-Dennerlein R
(7)
Urlaub H
(7)
Yang H
(7)
Agrawal RK
(6)
Barrientos A
(6)
Buschauer R
(6)
Denk T
(6)
Kazi R
(6)
Keshavan P
(6)
Koripella RK
(6)
Li Y
(6)
Wang M
(6)
Andrell J
(5)
Andréll J
(5)
Ban N
(5)
Cipullo M
(5)
Filipovska A
(5)
Lee RG
(5)
Leibundgut M
(5)
Lenarcic T
(5)
Lenarčič T
(5)
Rackham O
(5)
Saurer M
(5)
Scaiola A
(5)
Schoenhut T
(5)
Schonhut T
(5)
Schönhut T
(5)
Banavali NK
(4)
Brown A
(4)
Hallberg BM
(4)
Hällberg BM
(4)
Khawaja A
(4)
Kummer E
(4)
Sharma MR
(4)
Valentin Gese G
(4)
Atanassov I
(3)
Bai XC
(3)
Del'Olio S
(3)
Flygaard RK
(3)
Hassan A
(3)
Izumikawa K
(3)
Jaskolowski M
(3)
Naschberger A
(3)
Nguyen MD
(3)
Nobe Y
(3)
Taoka M
(3)
Whitford PC
(3)
Abdelbagi A
(2)
Agrawal EK
(2)
Andrews B
(2)
Battersby BJ
(2)
Benhalevy D
(2)
Best RB
(2)
Bhargava K
(2)
Cai Y
(2)
Choi A
(2)
Datta PP
(2)
Deep A
(2)
Dent KC
(2)
Dinan A
(2)
Dreos R
(2)
Firth AE
(2)
Garone C
(2)
Gatfield D
(2)
Gese GV
(2)
Gesé GV
(2)
Gopalakrishna S
(2)
Hafner M
(2)
Kaushal PS
(2)
Kimanius D
(2)
Koripella R
(2)
Krueger A
(2)
Liu Y
(2)
Lobo V
(2)
Maiti P
(2)
Marks J
(2)
Miller-Fleming L
(2)
Misic J
(2)
Nadimpalli HP
(2)
Nguyen TG
(2)
 
More...
 
Homo / hetero assembly  (1)
hetero
(69)
 
Assembly composition  (2)
RNA/protein complex
(67)
DNA/RNA/protein complex
(2)
 
Assembly polymer count  (27)
94-mer
(6)
55-mer
(5)
56-mer
(5)
57-mer
(5)
52-mer
(4)
58-mer
(4)
91-mer
(4)
93-mer
(4)
53-mer
(3)
83-mer
(3)
90-mer
(3)
92-mer
(3)
51-mer
(2)
54-mer
(2)
60-mer
(2)
85-mer
(2)
86-mer
(2)
30-mer
(1)
46-mer
(1)
49-mer
(1)
59-mer
(1)
62-mer
(1)
63-mer
(1)
66-mer
(1)
69-mer
(1)
87-mer
(1)
96-mer
(1)
 
Resolution distribution
2.0 - 2.5
(6)
2.5 - 3
(19)
3.0 - 3.5
(28)
3.5 - 4
(10)
4.0 - 4.5
(4)
4.5 - 5
(1)
5.5 - 6
(1)
 
Release year distribution
2010 - 2015
(2)
2015 - 2020
(21)
2020 - 2025
(63)
2025 - 2030
(1)
 
Journal  (8)
Nat Commun
(40)
Science
(12)
Elife
(9)
Nat Struct Mol Biol
(3)
Proc Natl Acad Sci U S A
(2)
Cell Rep
(1)
Nature
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(69)
 
Organism name  (1)
Homo sapiens
(69)
 
Molecule name  (7)
39S ribosomal protein L28, mitochondrial
(69)
39S ribosomal protein L30, mitochondrial
(69)
L28mt
(69)
L30mt
(69)
Large ribosomal subunit protein uL30m
(69)
MRP-L28
(69)
MRP-L30
(69)
 
Molecule type  (1)
Protein
(69)
 
Gene names  (4)
HSPC249
(69)
MRPL28
(69)
MRPL30
(69)
RPML28
(69)
 
Interacting Molecules  (166)
Large ribosomal subunit protein bL17m
(69)
Large ribosomal subunit protein bL19m
(69)
Large ribosomal subunit protein bL20m
(69)
Large ribosomal subunit protein bL21m
(69)
Large ribosomal subunit protein bL27m
(69)
Large ribosomal subunit protein bL32m
(69)
Large ribosomal subunit protein bL34m
(69)
Large ribosomal subunit protein bL9m
(69)
Large ribosomal subunit protein mL37
(69)
Large ribosomal subunit protein mL38
(69)
Large ribosomal subunit protein uL13m
(69)
Large ribosomal subunit protein uL14m
(69)
Large ribosomal subunit protein uL15m
(69)
Large ribosomal subunit protein uL16m
(69)
Large ribosomal subunit protein uL22m
(69)
Large ribosomal subunit protein uL23m
(69)
Large ribosomal subunit protein uL24m
(69)
Large ribosomal subunit protein uL29m
(69)
Large ribosomal subunit protein uL2m
(69)
Large ribosomal subunit protein uL3m
(69)
Large ribosomal subunit protein uL4m
(69)
Large ribosomal subunit protein bL28m
(68)
Large ribosomal subunit protein bL33m
(68)
Large ribosomal subunit protein bL35m
(68)
Large ribosomal subunit protein mL39
(68)
Large ribosomal subunit protein mL41
(68)
Large ribosomal subunit protein mL42
(68)
Large ribosomal subunit protein mL43
(68)
Large ribosomal subunit protein mL44
(68)
Large ribosomal subunit protein mL45
(68)
Large ribosomal subunit protein mL49
(68)
Large ribosomal subunit protein mL50
(68)
Large ribosomal subunit protein mL51
(68)
Large ribosomal subunit protein mL52
(68)
Large ribosomal subunit protein mL62
(68)
Large ribosomal subunit protein mL63
(68)
Large ribosomal subunit protein mL64
(68)
Large ribosomal subunit protein mL65
(68)
Large ribosomal subunit protein mL66
(68)
Large ribosomal subunit protein uL10m
(67)
Large ribosomal subunit protein uL11m
(67)
Large ribosomal subunit protein mL48
(66)
Large ribosomal subunit protein mL53
(66)
Large ribosomal subunit protein mL40
(65)
Large ribosomal subunit protein mL46
(65)
Large ribosomal subunit protein mL55
(64)
Large ribosomal subunit protein mL54
(61)
Large ribosomal subunit protein uL18m
(57)
Large ribosomal subunit protein bL36m
(56)
16S ribosomal RNA
(49)
Acyl carrier protein, mitochondrial
(29)
Mitochondrial assembly of ribosomal large subunit protein 1
(29)
Mitochondrial ribosome and complex I assembly factor AltMIEF1
(29)
Small ribosomal subunit protein bS16m
(29)
Small ribosomal subunit protein bS18m
(29)
Small ribosomal subunit protein bS1m
(29)
Small ribosomal subunit protein bS6m
(29)
Small ribosomal subunit protein mS22
(29)
Small ribosomal subunit protein mS23
(29)
Small ribosomal subunit protein mS25
(29)
Small ribosomal subunit protein mS26
(29)
Small ribosomal subunit protein mS27
(29)
Small ribosomal subunit protein mS29
(29)
Small ribosomal subunit protein mS31
(29)
Small ribosomal subunit protein mS33
(29)
Small ribosomal subunit protein mS35
(29)
Small ribosomal subunit protein mS37
(29)
Small ribosomal subunit protein mS38
(29)
Small ribosomal subunit protein mS39
(29)
Small ribosomal subunit protein mS40
(29)
Small ribosomal subunit protein uS10m
(29)
Small ribosomal subunit protein uS11m
(29)
Small ribosomal subunit protein uS12m
(29)
Small ribosomal subunit protein uS14m
(29)
Small ribosomal subunit protein uS15m
(29)
Small ribosomal subunit protein uS17m
(29)
Small ribosomal subunit protein uS2m
(29)
Small ribosomal subunit protein uS3m
(29)
Small ribosomal subunit protein uS5m
(29)
Small ribosomal subunit protein uS7m
(29)
Small ribosomal subunit protein uS9m
(29)
Small ribosomal subunit protein mS34
(28)
mitochondrial tRNAVal
(27)
Small ribosomal subunit protein bS21m
(26)
Large ribosomal subunit protein bL12m
(23)
Messenger RNA
(18)
16S mitochondrial rRNA
(15)
12S mitochondrial rRNA
(14)
5-cytosine rRNA methyltransferase NSUN4
(13)
Transcription termination factor 4, mitochondrial
(13)
cDNA FLJ76688, highly similar to Homo sapiens HSPC071 mRNA
(12)
12S rRNA
(11)
mt-tRNAVal
(11)
mitochondrial Val tRNA
(9)
E-site tRNA
(8)
Large ribosomal subunit protein uL1m
(8)
Quinupristin
(7)
P-site tRNA
(6)
Unknown protein/protein extension
(6)
Val tRNA
(6)
 
More...
 
Function and Biology
Biological function  (1)
structural constituent of ribosome
(68)
 
Biological process  (2)
translation
(68)
mitochondrial translation
(66)
 
Biological cell component  (6)
large ribosomal subunit
(68)
mitochondrial inner membrane
(66)
mitochondrial large ribosomal subunit
(66)
mitochondrion
(66)
ribonucleoprotein complex
(66)
ribosome
(66)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF00327 : Ribosomal_L30
(69)
 
Experimental Information
Refinement software  (3)
PHENIX
(11)
phenix.real_space_refine
(9)
REFMAC
(4)
 
EM microscope model  (3)
FEI TITAN KRIOS
(62)
TFS KRIOS
(6)
FEI TITAN
(1)
 
EM detector name  (8)
GATAN K2 SUMMIT (4k x 4k)
(20)
FEI FALCON II (4k x 4k)
(13)
FEI FALCON III (4k x 4k)
(12)
GATAN K3 BIOQUANTUM (6k x 4k)
(11)
GATAN K3 (6k x 4k)
(9)
FEI FALCON IV (4k x 4k)
(2)
DIRECT ELECTRON DE-16 (4k x 4k)
(1)
GATAN K2 QUANTUM (4k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 69
Entries 1 to 10 of 69
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55S human mitochondrial ribosome with mtRF1 and P-site tRNA
Saurer M, Leibundgut M, Scaiola A, Schoenhut T, Ban N
Science (2023) [PMID: 37141370  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GDP    K    K    MG    VAL    ZN    VAL    ZN    ATP    GDP    MG    ATP    MET    MET   
Modified residues: OMG    5MC    N    OMU    SAC    Y5P    5F0    ACE    5MC    ACE    2MG    5MU    5MU    MA6    N    SAC    Y5P    1MA    AYA    RSQ    RSQ    1MA    2MG    AYA    B8T    PSU    PSU    MA6    OMG    OMU   
PDBe complex ID: PDB-CPX-218031 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q9Y3D3    P82663    P82930    Q9P0M9    Q7Z7H8    (view 77 more)
Electron Microscopy
3.1Å resolution
Released: 14 Jun 2023
Model geometry
Fit model/data
Data not analysed
8oir
8oir
8oir
39S human mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA
Saurer M, Leibundgut M, Scaiola A, Schoenhut T, Ban N
Science (2023) [PMID: 37141370  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: K    K    MG    VAL    ZN    VAL    ZN    MG    MET    MET   
Modified residues: OMG    OMU    SAC    ACE    ACE    2MG    SAC    1MA    AYA    RSQ    RSQ    1MA    2MG    AYA    PSU    PSU    OMG    OMU   
PDBe complex ID: PDB-CPX-218035 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q9P0M9    Q7Z7H8    Q9P015    Q9BYC9    Q14197    (view 47 more)
Electron Microscopy
2.9Å resolution
Released: 14 Jun 2023
Model geometry
Fit model/data
Data not analysed
8oit
8oit
8oit
Structural insights into unique features of the human mitochondrial ribosome recycling
Sharma MR, Koripella RK, Agrawal RK
Proc Natl Acad Sci U S A (2019) [PMID: 30962385  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-289350 (Preferred)   search this ID
PDBe-KB: Q8TCC3    P82930    Q9Y3D3    P82663    Q7Z7H8    Q9P015    (view 75 more)
Electron Microscopy
3.9Å resolution
Released: 17 Apr 2019
Model geometry
Fit model/data
Data not analysed
6nu2
6nu2
6nu2
Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nat Struct Mol Biol (2017) [PMID: 28892042  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: PNS    MG    ZN    ZN    MG    PNS   
PDBe complex ID: PDB-CPX-289300 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q7Z7H8    Q9P015    Q9BYC9    Q9P0M9    Q14197    (view 46 more)
Electron Microscopy
3.03Å resolution
Released: 13 Sep 2017
Model geometry
Fit model/data
Data not analysed
5oom
5oom
5oom
Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nat Struct Mol Biol (2017) [PMID: 28892042  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: PNS    MG    ZN    ZN    MG    PNS   
PDBe complex ID: PDB-CPX-289299 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q7Z7H8    Q9P015    Q9BYC9    Q9P0M9    Q14197    (view 47 more)
Electron Microscopy
3.06Å resolution
Released: 13 Sep 2017
Model geometry
Fit model/data
Data not analysed
5ool
5ool
5ool
Structural insights into unique features of the human mitochondrial ribosome recycling
Sharma MR, Koripella RK, Agrawal RK
Proc Natl Acad Sci U S A (2019) [PMID: 30962385  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-289225 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q9Y3D3    P82663    Q7Z7H8    Q9P015    Q9BYC9    (view 74 more)
Electron Microscopy
4.4Å resolution
Released: 17 Apr 2019
Model geometry
Fit model/data
Data not analysed
6nu3
6nu3
6nu3
Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline
Li X, Wang M, Cheng J
Nat Commun (2024) [PMID: 38942792  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GDP    MG    ZN    ZN    GDP    MG    T1C    T1C   
Assembly name: ribosomal protein and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-280502 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q14197    Q7Z7H8    Q9P015    Q9BYC9    Q9P0M9    (view 74 more)
Electron Microscopy
3.2Å resolution
Released: 10 Jul 2024
Model geometry
Fit model/data
Data not analysed
8xt0
8xt0
8xt0
Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline
Li X, Wang M, Cheng J
Nat Commun (2024) [PMID: 38942792  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GDP    MG    ZN    ZN    GDP    MG    T1C    T1C   
Assembly name: ribosomal protein and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-280503 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q14197    Q7Z7H8    Q9P015    Q9BYC9    Q9P0M9    (view 74 more)
Electron Microscopy
3.3Å resolution
Released: 10 Jul 2024
Model geometry
Fit model/data
Data not analysed
8xt2
8xt2
8xt2
mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 1
Valentin Gese G, Cipullo M, Rorbach J, Hallberg BM
Nat Commun (2024) [PMID: 38969660  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Assembly name: Large ribosomal protein and tRNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-289430 (Preferred)   search this ID
PDBe-KB: Q8TCC3    Q7Z7H8    Q9P015    Q9BYC9    Q9P0M9    Q96DV4    (view 22 more)
Electron Microscopy
2.74Å resolution
Released: 26 Jun 2024
Model geometry
Fit model/data
Data not analysed
8qu1
8qu1
8qu1
Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA)
Singh V, Itoh Y, Amunts A
Nat Commun (2024) [PMID: 38769321  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GDP    K    SPD    K    MG    VAL    FES    ZN    VAL    NAD    ZN    ATP    GDP    MG    SPM    ATP    PUT    FES   
Modified residues: OMG    5MC    OMU    SAC    5F0    5MC    2MG    5MU    5MU    MA6    SAC    1MA    AYA    THC    1MA    2MG    AYA    B8T    PSU    PSU    MA6    OMG    OMU    THC   
PDBe complex ID: PDB-CPX-288636 (Preferred)   search this ID
PDBe-KB: Q8TCC3    P82930    Q9Y3D3    P82663    Q7Z7H8    Q9P015    (view 76 more)
Electron Microscopy
2.21Å resolution
Released: 13 Jul 2022
Model geometry
Fit model/data
Data not analysed
7qi4
7qi4
7qi4
...
Entries 1 to 10 of 69
Entries 1 to 10 of 69