Uniprot accession / id : Q9DCS3  OR   Uniprot accession / id : Q9BV79
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
X-ray diffraction
(4)
 
Authors  (29)
Hiltunen JK
(3)
Wierenga RK
(3)
Autio KJ
(2)
Kalervo Hiltunen J
(2)
Kastaniotis AJ
(2)
Koski MK
(2)
Kristian Koski M
(2)
Panecka-Hofman J
(2)
Rahman MT
(2)
Schmitz W
(2)
Tanvir Rahman M
(2)
Wade RC
(2)
Arrowsmith C
(1)
Chen ZJ
(1)
Edwards A
(1)
Haapalainen AM
(1)
Johansson C
(1)
Juffer AH
(1)
Kavanagh KL
(1)
Lukacik P
(1)
Oppermann U
(1)
Pudas R
(1)
Shafqat N
(1)
Sharma S
(1)
Smart OS
(1)
Smee C
(1)
Structural Genomics Consortium (SGC)
(1)
Sundstrom M
(1)
von Delft F
(1)
 
Homo / hetero assembly  (1)
homo
(4)
 
Assembly composition  (1)
protein structure
(4)
 
Assembly polymer count  (1)
dimer
(4)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(2)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(2)
2020 - 2025
(2)
 
Journal  (3)
Nat Commun
(2)
J Mol Biol
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (5)
2-enoyl thioester reductase
(4)
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
(4)
HsNrbf-1
(4)
NRBF-1
(4)
Nuclear receptor-binding factor 1
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (3)
CGI-63
(4)
MECR
(4)
NBRF1
(4)
 
Interacting ligands  (5)
CL : CHLORIDE ION
(2)
GOL : GLYCEROL
(2)
SO4 : SULFATE ION
(2)
ACY : ACETIC ACID
(1)
PO4 : PHOSPHATE ION
(1)
 
Function and Biology
EC number / name  (1)
1.3.1.104 : Enoyl-[acyl-carrier-protein] reductase
(4)
 
Biological function  (2)
enoyl-[acyl-carrier-protein] reductase (NADPH) activity
(4)
oxidoreductase activity
(4)
 
Biological process  (5)
ceramide biosynthetic process
(4)
fatty acid biosynthetic process
(4)
fatty acid metabolic process
(4)
intracellular iron ion homeostasis
(4)
lipid metabolic process
(4)
 
Biological cell component  (5)
cytoplasm
(4)
membrane
(4)
mitochondrial matrix
(4)
mitochondrion
(4)
nucleus
(4)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (2)
Quinone Oxidoreductase; Chain A, domain 1
(2)
Rossmann fold
(2)
 
Pfam accession / name  (2)
PF00107 : ADH_zinc_N
(4)
PF08240 : ADH_N
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
DIAMOND BEAMLINE I04
(2)
EMBL/DESY, HAMBURG BEAMLINE BW7A
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (3)
Diamond
(2)
EMBL/DESY, Hamburg
(1)
SLS
(1)
 
Diffraction detector type  (2)
CCD
(2)
Pixel
(2)
 
Refinement software  (2)
REFMAC
(3)
BUSTER-TNT
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Crystal Structure of wild type human mitochondrial 2-Enoyl Thioester Reductase (MECR)
Rahman MT, Koski MK, Autio KJ, Kastaniotis AJ, Wierenga RK, Hiltunen JK
Nat Commun (2023) [PMID: 36739436  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ACY    GOL    CL    ACY    PO4   
Assembly name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189754 (Preferred)   search this ID
PDBe-KB: Q9BV79   
X-ray diffraction
1.85Å resolution
Released: 1 Jun 2022
Model geometry
Fit model/data
7ayb
7ayb
7ayb
Crystal Structure of human mitochondrial 2-Enoyl Thioester Reductase (MECR) with single mutation G165Q
Rahman MT, Koski MK, Autio KJ, Kastaniotis AJ, Wierenga RK, Hiltunen JK
Nat Commun (2023) [PMID: 36739436  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CL   
Assembly name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189754 (Preferred)   search this ID
PDBe-KB: Q9BV79   
X-ray diffraction
2.02Å resolution
Released: 1 Jun 2022
Model geometry
Fit model/data
7ayc
7ayc
7ayc
The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)
Lukacik P, Shafqat N, Kavanagh KL, Johansson C, Smee C, Edwards A, Arrowsmith C, Sundstrom M, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    SO4   
Assembly name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189754 (Preferred)   search this ID
PDBe-KB: Q9BV79   
X-ray diffraction
1.75Å resolution
Released: 7 Jun 2005
Model geometry
Fit model/data
1zsy
1zsy
1zsy
Crystal Structure of 2-Enoyl Thioester Reductase of Human FAS II
Haapalainen AM, Pudas R, Smart OS, Wierenga RK
J Mol Biol (2008) [PMID: 18479707  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189754 (Preferred)   search this ID
PDBe-KB: Q9BV79   
X-ray diffraction
2.41Å resolution
Released: 3 Jun 2008
Model geometry
Data not analysed
Fit model/data
2vcy
2vcy
2vcy
Entries 1 to 4 of 4
Entries 1 to 4 of 4