Uniprot accession / id : Q9EPJ9  OR   Uniprot accession / id : Q8N6T3  OR   Uniprot accession / id : H0YIQ0
 
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Entry Information
Entry status  (1)
REL
(2)
 
Experimental methods  (1)
X-ray diffraction
(2)
 
Authors  (15)
Arrowsmith CH
(2)
Bochkarev A
(2)
Bountra C
(2)
Edwards AM
(2)
Nedyalkova L
(2)
Park H
(2)
Structural Genomics Consortium (SGC)
(2)
Tempel W
(2)
Tong Y
(2)
Crombet L
(1)
Guan X
(1)
Landry R
(1)
Wang H
(1)
Weigelt J
(1)
Wilkstrom M
(1)
 
Homo / hetero assembly  (1)
homo
(2)
 
Assembly composition  (1)
protein structure
(2)
 
Assembly polymer count  (1)
dimer
(2)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(1)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(1)
 
Journal  (1)
To be published
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(2)
 
Organism name  (1)
Homo sapiens
(2)
 
Molecule name  (6)
ADP-ribosylation factor 1 GTPase-activating protein
(2)
ADP-ribosylation factor GTPase-activating protein 1
(2)
ARF GAP 1
(2)
ARF1 GAP
(2)
ARF1-directed GTPase-activating protein
(2)
ADP-ribosylation factor 1
(1)
 
Molecule type  (1)
Protein
(2)
 
Gene names  (3)
ARF1GAP
(2)
ARFGAP1
(2)
ARF1
(1)
 
Interacting ligands  (2)
ZN : ZINC ION
(2)
GDP : GUANOSINE-5'-DIPHOSPHATE
(1)
 
Function and Biology
EC number / name  (1)
3.6.5.2 : Small monomeric GTPase
(1)
 
Biological function  (9)
GTPase activator activity
(2)
GTP binding
(1)
GTPase activity
(1)
RNA binding
(1)
hydrolase activity
(1)
magnesium ion binding
(1)
nucleotide binding
(1)
protein binding
(1)
protein domain specific binding
(1)
 
Biological process  (10)
cellular response to virus
(1)
dendritic spine organization
(1)
intracellular copper ion homeostasis
(1)
intracellular protein transport
(1)
long-term synaptic depression
(1)
mitotic cleavage furrow ingression
(1)
protein transport
(1)
regulation of Arp2/3 complex-mediated actin nucleation
(1)
regulation of receptor internalization
(1)
vesicle-mediated transport
(1)
 
Biological cell component  (15)
Golgi apparatus
(1)
Golgi membrane
(1)
cell leading edge
(1)
cytoplasm
(1)
cytosol
(1)
endomembrane system
(1)
extracellular exosome
(1)
focal adhesion
(1)
membrane
(1)
neuron projection
(1)
plasma membrane
(1)
postsynaptic density
(1)
protein-containing complex
(1)
sarcomere
(1)
synapse
(1)
 
Sequence and Structure classification
CATH class  (2)
Mainly Alpha
(2)
Alpha Beta
(1)
 
CATH topology  (2)
Annexin V; domain 1
(2)
Rossmann fold
(1)
 
Pfam accession / name  (2)
PF01412 : ArfGap
(2)
PF00025 : Arf
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
APS BEAMLINE 19-ID
(1)
CLSI BEAMLINE 08ID-1
(1)
 
Synchrotron site  (2)
APS
(1)
CLSI
(1)
 
Diffraction detector type  (1)
CCD
(2)
 
Refinement software  (3)
BUSTER
(1)
BUSTER-TNT
(1)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 2 of 2
Entries 1 to 2 of 2
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Crystal structure of ARFGAP1-ARF1 fusion protein
Wang H, Tong Y, Nedyalkova L, Tempel W, Guan X, Crombet L, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GDP    ZN    ZN    GDP   
Assembly name: ADP-ribosylation factor 1, ADP-ribosylation factor GTPase-activating protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160793 (Preferred)   search this ID
PDBe-KB: Q8N6T3    P84077   
X-ray diffraction
2.8Å resolution
Released: 11 Aug 2010
Model geometry
Fit model/data
3o47
3o47
3o47
Crystal structure of the ArfGAP domain of human ARFGAP1
Nedyalkova L, Tong Y, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Bountra C, Wilkstrom M, Bochkarev A, Park H, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: ADP-ribosylation factor GTPase-activating protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-185424 (Preferred)   search this ID
PDBe-KB: Q8N6T3   
X-ray diffraction
2.4Å resolution
Released: 5 Aug 2008
Model geometry
Fit model/data
3dwd
3dwd
3dwd
Entries 1 to 2 of 2
Entries 1 to 2 of 2