Entry status  (1)

REL

(100)

Experimental methods  (2)

X-ray diffraction

(99)

Solution NMR

(1)

Authors  (50)

Benesch JLP

(97)

Bountra C

(97)

Bradshaw WJ

(97)

Brennan PE

(97)

Chalk R

(97)

Gileadi O

(97)

Katis VL

(97)

Kennedy EC

(97)

Moreira T

(97)

Murphy EJ

(97)

Smith LA

(97)

von Delft F

(97)

Arrowsmith CH

(93)

Edwards AM

(92)

Newman JA

(91)

Pascoa TC

(3)

Fernandez-Cid A

(2)

Scacioc A

(2)

Andersen RJ

(1)

Ban F

(1)

Burgess-Brown N

(1)

Burgess-Brown NA

(1)

Chamberlain TC

(1)

Cherkasov A

(1)

Cheung ST

(1)

Dzananovic E

(1)

Edwards A

(1)

Gardill BR

(1)

Hamdani AK

(1)

Harada T

(1)

Jawanda K

(1)

Kasai T

(1)

Kigawa T

(1)

Koshiba S

(1)

Krystal G

(1)

McKenna SA

(1)

Mckinley G

(1)

Mesecar AD

(1)

Ming-Lum A

(1)

Mui AL

(1)

Ong CJ

(1)

Priatel J

(1)

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(1)

Samiea A

(1)

Shakibakho S

(1)

Van Petegem F

(1)

Watanabe S

(1)

Williams EP

(1)

Yokoyama S

(1)

Yoon JSJ

(1)

Homo / hetero assembly  (1)

homo

(100)

Assembly composition  (1)

protein structure

(100)

Assembly polymer count  (1)

monomer

(100)

Resolution distribution

1.0 - 1.5

(72)

1.5 - 2

(27)

Release year distribution

2005 - 2010

(1)

2015 - 2020

(94)

2020 - 2025

(97)

Journal  (3)

Structure

(97)

To be published

(2)

Biorxiv

(1)

Organism superkingdom  (1)

Eukaryota

(100)

Organism name  (2)

Homo sapiens

(99)

Mus musculus

(1)

Molecule name  (11)

Inositol polyphosphate-5-phosphatase D

(100)

Inositol polyphosphate-5-phosphatase of 145 kDa

(100)

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

(100)

SH2 domain-containing inositol 5'-phosphatase 1

(100)

SH2 domain-containing inositol phosphatase 1

(100)

SHIP-1

(100)

SIP-145

(100)

p150Ship

(100)

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase

(99)

hp51CN

(99)

Phosphatidylinositol-4,5-bisphosphate 5-phosphatase

(1)

Molecule type  (1)

Protein

(100)

Gene names  (7)

INPP5D

(99)

SHIP

(99)

SHIP1

(99)

7a33

(1)

Inpp5d

(1)

Ship

(1)

Ship1

(1)

Interacting ligands  (105)

DMS : DIMETHYL SULFOXIDE

(97)

PO4 : PHOSPHATE ION

(7)

MG : MAGNESIUM ION

(2)

2L1 : 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinoline

(1)

AWD : ~{N}-(4-fluorophenyl)-4-methyl-piperazine-1-carboxamide

(1)

AXG : 1-(phenylmethyl)-4-pyrrol-1-yl-piperidine

(1)

AXS : 1-(4-fluorophenyl)-~{N}-[[(2~{R})-oxolan-2-yl]methyl]methanamine

(1)

B1J : [1-(4-chlorophenyl)-1,2,3-triazol-4-yl]methanol

(1)

BTB : 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(1)

EDO : 1,2-ETHANEDIOL

(1)

ELQ : [3,4-bis(fluoranyl)phenyl]-(4-methylpiperazin-1-yl)methanone

(1)

GX4 : cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone

(1)

H0D : N-(4-chlorophenyl)-N'-[(2R)-1-hydroxybutan-2-yl]urea

(1)

IPA : ISOPROPYL ALCOHOL

(1)

JJG : 4-[2-(phenylsulfanyl)ethyl]morpholine

(1)

JMM : [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone

(1)

JO1 : 1-methyl-N-[(thiophen-2-yl)methyl]-1H-pyrazole-5-carboxamide

(1)

JOV : 3-chloro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide

(1)

K0G : N-phenyl-N'-pyridin-3-ylurea

(1)

K0V : methyl 1-(tert-butylcarbamoyl)piperidine-4-carboxylate

(1)

MN : MANGANESE (II) ION

(1)

NTG : 5-(1,4-oxazepan-4-yl)pyridine-2-carbonitrile

(1)

NU4 : 2-methyl-N-(pyridin-4-yl)furan-3-carboxamide

(1)

NUJ : trans-3-[(2,6-dimethylpyrimidin-4-yl)(methyl)amino]cyclobutan-1-ol

(1)

NV7 : 1-[(furan-2-yl)methyl]-4-(methylsulfonyl)piperazine

(1)

NVD : N-{[4-(dimethylamino)phenyl]methyl}-4H-1,2,4-triazol-4-amine

(1)

NVY : 1-ethyl-N-(2-fluorophenyl)piperidin-4-amine

(1)

NZ4 : N-(3-acetylphenyl)morpholine-4-carboxamide

(1)

O0P : N-[(3-fluorophenyl)methyl]-N-methylsulfuric diamide

(1)

O1M : 4-(4-fluorophenyl)piperazine-1-carboxamide

(1)

O3A : (3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide

(1)

O3D : 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione

(1)

O3G : N-benzyl-1-(4-fluorophenyl)methanamine

(1)

O3J : 1-[4-(3-phenylpropyl)piperazin-1-yl]ethan-1-one

(1)

O3M : 4-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol

(1)

PGE : TRIETHYLENE GLYCOL

(1)

QKZ : 2-(4-chlorophenyl)-~{N}-pyrimidin-2-yl-ethanamide

(1)

RWV : 1-{1-[(2-methyl-1,3-thiazol-4-yl)methyl]piperidin-4-yl}methanamine

(1)

RX7 : 2-methyl-2-{[(3-methylthiophen-2-yl)methyl]amino}propan-1-ol

(1)

RXJ : 4-(4-methylpiperazin-1-yl)benzonitrile

(1)

RXS : 3-[(2-methyl-1H-imidazol-1-yl)methyl]benzonitrile

(1)

S07 : 2-(2,4-dimethylphenoxy)-1-morpholin-4-yl-ethanone

(1)

S7J : 2-(trifluoromethyl)pyrimidine-5-carboxamide

(1)

S8G : 1-[(3~{R})-3-azanylpiperidin-1-yl]-4,4,4-tris(fluoranyl)butan-1-one

(1)

T0J : N~1~-phenylpiperidine-1,4-dicarboxamide

(1)

T0V : 1-(3-fluorophenyl)-N-[(furan-2-yl)methyl]methanamine

(1)

T0Y : 1-[(thiophen-3-yl)methyl]piperidin-4-ol

(1)

T1S : 4-[(3-chlorophenyl)methyl]morpholine

(1)

U0V : 2-fluoro-N-[2-(pyridin-4-yl)ethyl]benzamide

(1)

UWV : 2-fluoro-N-[(1H-pyrazol-3-yl)methyl]aniline

(1)

VWA : (1S)-1-(4-fluorophenyl)-N-methylethan-1-amine

(1)

VZM : N-(6-methoxypyridin-3-yl)-N'-thiophen-2-ylurea

(1)

W0M : (2R)-2-(4-chlorophenoxy)propanamide

(1)

WHV : (1S)-1-(2,4-dimethyl-1,3-thiazol-5-yl)-N-methylethan-1-amine

(1)

WK4 : 2-(1H-imidazol-1-yl)ethyl dimethylcarbamate

(1)

WK7 : 3-fluoro-4-(piperazin-1-yl)benzonitrile

(1)

WKA : N-(2,1,3-benzoxadiazol-4-yl)acetamide

(1)

WKD : (2R)-2-(4-cyanophenoxy)propanamide

(1)

WKG : 1-(2-azaspiro[5.6]dodecan-2-yl)ethan-1-one

(1)

WKJ : (3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-ol

(1)

WKM : (2S)-2-amino-3-methyl-1-(morpholin-4-yl)butan-1-one

(1)

WKP : (4-methoxyphenyl)(piperidin-4-yl)methanone

(1)

WKS : 2,4-dimethyl-6-(piperazin-1-yl)pyrimidine

(1)

WKV : N-[(5-bromo-2-methoxyphenyl)methyl]acetamide

(1)

WKY : N-(3-methylpyridin-4-yl)acetamide

(1)

WL1 : methyl 4-sulfanylbenzoate

(1)

WL4 : N-(3-cyanophenyl)-2-methylpropanamide

(1)

WL7 : 4-amino-N-(2-hydroxyethyl)-N-methylbenzene-1-sulfonamide

(1)

WLA : 1-[(oxan-4-yl)methyl]piperazine

(1)

WLD : (2S)-1-{[(2,6-dichlorophenyl)methyl]amino}propan-2-ol

(1)

WLG : 1-(5-azaspiro[2.5]octan-5-yl)-2-(difluoromethoxy)ethan-1-one

(1)

WLJ : (azepan-1-yl)(2,6-difluorophenyl)methanone

(1)

WLP : 2-chlorobenzene-1-thiol

(1)

WLS : 1-(pyridin-4-yl)-N-[(thiophen-2-yl)methyl]methanamine

(1)

WLV : N-(3-fluorophenyl)-2-phenoxyacetamide

(1)

WLY : 2-(4-methylphenyl)-N-{[(2S)-oxolan-2-yl]methyl}acetamide

(1)

WM7 : (3S)-N-benzylpyrrolidin-3-amine

(1)

WMD : 1-[(1R)-1-(2-fluorophenyl)ethyl]piperazine

(1)

WMG : 1-[(1S)-1-(2-fluorophenyl)ethyl]piperazine

(1)

WMS : 5-fluoro-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyridin-3-amine

(1)

WMV : N-(2-cyclohexylethyl)-3,5-dimethyl-1,2-oxazole-4-carboxamide

(1)

WMY : 3-chloro-N-(1,2-oxazol-3-yl)benzamide

(1)

WN1 : N-(2-fluorophenyl)-3-methoxybenzamide

(1)

WN4 : N-(6-methylpyridin-2-yl)-L-prolinamide

(1)

WN7 : 5-methyl-N-[(pyridin-4-yl)methyl]pyridin-3-amine

(1)

WNA : 1-methyl-N-[(2-methylphenyl)methyl]-1H-tetrazol-5-amine

(1)

WND : 2-methyl-1-[(oxan-4-yl)amino]propan-2-ol

(1)

WNG : N-[(Z)-2-phenylethenyl]-1H-benzimidazol-2-amine

(1)

WNJ : N-{[(3R)-pyrrolidin-3-yl]methyl}pyridin-2-amine

(1)

WNM : (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine

(1)

WNP : N-(3-chlorophenyl)-2,2,2-trifluoroacetamide

(1)

WNS : N-(2-chloropyridin-3-yl)butanamide

(1)

WNV : N,N,2,3-tetramethylbenzamide

(1)

WNY : 1-[4-(4-chlorophenyl)piperazin-1-yl]ethan-1-one

(1)

WO1 : (3R)-1-methylpiperidin-3-yl furan-2-carboxylate

(1)

WO7 : 1-(1,4-diazepan-1-yl)ethan-1-one

(1)

WOA : (3S)-3-(methylamino)-1-phenylpiperidin-2-one

(1)

WOD : 3-cyclopropyl-5-[(3R)-pyrrolidin-3-yl]-1,2,4-oxadiazole

(1)

WOJ : (3S,4R)-3-methyl-1-(methylsulfonyl)piperidin-4-amine

(1)

WP4 : (3R)-N-benzylpyrrolidin-3-amine

(1)

 

More...

EC number / name  (3)

3.1.3.36 : Phosphoinositide 5-phosphatase

(100)

3.1.3.56 : Inositol-polyphosphate 5-phosphatase

(100)

3.1.3.86 : Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

(100)

Biological function  (1)

phosphatase activity

(99)

Biological process  (1)

phosphatidylinositol dephosphorylation

(99)

CATH class  (1)

Alpha Beta

(1)

CATH topology  (1)

SHC Adaptor Protein

(1)

Pfam accession / name  (2)

PF22669 : Exo_endo_phos2

(99)

PF00017 : SH2

(1)

Diffraction protocol  (1)

Single wavelength

(99)

Diffraction radiation source type  (1)

Synchrotron

(99)

Diffraction source  (4)

DIAMOND BEAMLINE I04-1

(91)

DIAMOND BEAMLINE I03

(6)

APS BEAMLINE 21-ID-F

(1)

APS BEAMLINE 23-ID-D

(1)

Synchrotron site  (2)

Diamond

(97)

APS

(2)

Diffraction detector type  (2)

Pixel

(98)

CCD

(1)

Refinement software  (2)

REFMAC

(97)

PHENIX

(2)

NMR software packages  (5)

CYANA

(1)

KUJIRA

(1)

NMRPipe

(1)

NMRView

(1)

XwinNMR

(1)

NMR Field Strength

700.0 - 800

(1)

800.0 - 900

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%