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Entry Information
Entry status
(1)
Experimental methods
(3)
Electron Microscopy
(41)
Solution NMR
(1)
X-ray diffraction
(1)
Authors
(82)
Chen X
(21)
Liu W
(14)
Wang X
(14)
Xu Y
(14)
Ren Y
(12)
Qu X
(10)
Cramer P
(9)
Wang H
(9)
He Y
(8)
Li W
(8)
Wang Q
(8)
Cui Y
(7)
Fang J
(7)
Golebiowski FM
(7)
Hanaoka F
(7)
Ivanov I
(7)
Kim J
(7)
Li CL
(7)
Nogales E
(7)
Sugasawa K
(7)
Yan C
(7)
Yang W
(7)
Aibara S
(6)
Li J
(6)
Schilbach S
(6)
Tjian R
(6)
Inouye C
(5)
Qi Y
(4)
Wu Z
(4)
Yin X
(4)
Dienemann C
(3)
Abril-Garrido J
(2)
Dodd T
(2)
Grabbe F
(2)
Greber BJ
(2)
Hou H
(2)
Kisker C
(2)
Koelmel W
(2)
Kuper J
(2)
Li Y
(2)
Li Z
(2)
Lidschreiber M
(2)
Poterszman A
(2)
Tainer JA
(2)
Tsutakawa SE
(2)
Velychko T
(2)
Wang M
(2)
Yan CL
(2)
Yang H
(2)
Yu Z
(2)
Zhao D
(2)
Abdella R
(1)
Adams PD
(1)
Afonine PV
(1)
Barnett JT
(1)
Boelens R
(1)
Braun C
(1)
Chen S
(1)
Chernev A
(1)
Cianferani S
(1)
Cianférani S
(1)
Dominguez C
(1)
Egly JM
(1)
Fribourg S
(1)
Inouye CJ
(1)
Kad NM
(1)
Kellenberger E
(1)
Kieffer B
(1)
Kokic G
(1)
Marcoux J
(1)
Moras D
(1)
Nguyen THD
(1)
Radu L
(1)
Rengachari S
(1)
Schmitt DR
(1)
Schoenwetter E
(1)
Talyzina A
(1)
Tegunov D
(1)
Toso D
(1)
Toso DB
(1)
Urlaub H
(1)
Wasielewski E
(1)
Homo / hetero assembly
(2)
hetero
(42)
homo
(1)
Assembly composition
(4)
DNA/protein complex
(29)
DNA/RNA/protein complex
(9)
protein/protein complex
(4)
protein structure
(1)
Assembly polymer count
(18)
51-mer
(10)
dodecamer
(5)
29-mer
(4)
32-mer
(3)
octamer
(3)
76-mer
(2)
87-mer
(2)
decamer
(2)
tridecamer
(2)
undecamer
(2)
33-mer
(1)
40-mer
(1)
42-mer
(1)
56-mer
(1)
58-mer
(1)
dimer
(1)
monomer
(1)
nonamer
(1)
Resolution distribution
3.0 - 3.5
(5)
3.5 - 4
(8)
4.0 - 4.5
(8)
4.5 - 5
(1)
5.0 - 5.5
(2)
5.5 - 6
(2)
6.0 - 6.5
(5)
6.5 - 7
(1)
7.0 - 7.5
(6)
7.5 - 8
(1)
8.5 - 9
(2)
9.5 - 10
(1)
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2015 - 2020
(11)
2020 - 2025
(31)
Journal
(8)
Nature
(19)
Science
(15)
Mol Cell
(2)
Nat Struct Mol Biol
(2)
Nucleic Acids Res
(2)
Elife
(1)
J Biol Chem
(1)
Nat Commun
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(43)
Organism name
(1)
Homo sapiens
(43)
Molecule name
(5)
BTF2 p44
(43)
Basic transcription factor 2 44 kDa subunit
(43)
General transcription factor IIH polypeptide 2
(43)
General transcription factor IIH subunit 2
(43)
TFIIH basal transcription factor complex p44 subunit
(43)
Molecule type
(1)
Protein
(43)
Gene names
(2)
BTF2P44
(43)
GTF2H2
(43)
Interacting Molecules
(130)
General transcription factor IIH subunit 3
(42)
General transcription and DNA repair factor IIH helicase subunit XPD
(41)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB
(41)
General transcription factor IIH subunit 4
(41)
General transcription factor IIH subunit 5
(41)
General transcription factor IIH subunit 1
(34)
General transcription factor IIE subunit 1
(28)
CDK-activating kinase assembly factor MAT1
(26)
DNA-directed RNA polymerase II subunit RPB9
(26)
DNA-directed RNA polymerases I, II, and III subunit RPABC2
(26)
DNA-directed RNA polymerases I, II, and III subunit RPABC3
(26)
General transcription factor IIF subunit 1
(26)
General transcription factor IIF subunit 2
(26)
TATA-box-binding protein
(26)
Transcription initiation factor IIA subunit 2
(26)
Transcription initiation factor IIB
(26)
Transcription initiation factor IIE subunit beta
(26)
Transcription initiation factor IIA subunit 1
(24)
DNA-directed RNA polymerases I, II, and III subunit RPABC5
(22)
DNA-directed RNA polymerase II subunit E
(20)
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
(20)
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
(20)
DNA-directed RNA polymerase subunit
(20)
DNA-directed RNA polymerase subunit beta
(20)
RNA polymerase II, I and III subunit K
(20)
RNA polymerase Rpb4/RPC9 core domain-containing protein
(20)
Transcription initiation factor TFIID subunit 1
(14)
Transcription initiation factor TFIID subunit 10
(14)
Transcription initiation factor TFIID subunit 11
(14)
Transcription initiation factor TFIID subunit 12
(14)
Transcription initiation factor TFIID subunit 13
(14)
Transcription initiation factor TFIID subunit 2
(14)
Transcription initiation factor TFIID subunit 3
(14)
Transcription initiation factor TFIID subunit 4
(14)
Transcription initiation factor TFIID subunit 5
(14)
Transcription initiation factor TFIID subunit 6
(14)
Transcription initiation factor TFIID subunit 7
(14)
Transcription initiation factor TFIID subunit 8
(14)
Transcription initiation factor TFIID subunit 9
(14)
Cyclin-H
(11)
Cyclin-dependent kinase 7
(11)
DNA-directed RNA polymerase II subunit RPB7
(10)
RNA
(9)
Alpha-amanitin
(8)
DNA-directed RNA polymerase II subunit RPB1
(8)
non-template DNA
(8)
template DNA
(8)
DNA repair protein complementing XP-C cells
(7)
Non-template DNA
(7)
Template DNA
(7)
DNA
(6)
DNA repair protein complementing XP-A cells
(6)
DNA-directed RNA polymerase II subunit RPB11-a
(6)
DNA-directed RNA polymerase II subunit RPB2
(6)
DNA-directed RNA polymerase II subunit RPB3
(6)
DNA-directed RNA polymerase II subunit RPB4
(6)
DNA-directed RNA polymerases I, II, and III subunit RPABC1
(6)
DNA-directed RNA polymerases I, II, and III subunit RPABC4
(6)
Mediator of RNA polymerase II transcription subunit 10
(6)
Mediator of RNA polymerase II transcription subunit 11
(6)
Mediator of RNA polymerase II transcription subunit 14
(6)
Mediator of RNA polymerase II transcription subunit 17
(6)
Mediator of RNA polymerase II transcription subunit 18
(6)
Mediator of RNA polymerase II transcription subunit 19
(6)
Mediator of RNA polymerase II transcription subunit 20
(6)
Mediator of RNA polymerase II transcription subunit 21
(6)
Mediator of RNA polymerase II transcription subunit 22
(6)
Mediator of RNA polymerase II transcription subunit 27
(6)
Mediator of RNA polymerase II transcription subunit 28
(6)
Mediator of RNA polymerase II transcription subunit 30
(6)
Mediator of RNA polymerase II transcription subunit 31
(6)
Mediator of RNA polymerase II transcription subunit 4
(6)
Mediator of RNA polymerase II transcription subunit 6
(6)
Mediator of RNA polymerase II transcription subunit 7
(6)
Mediator of RNA polymerase II transcription subunit 8
(6)
Mediator of RNA polymerase II transcription subunit 9
(6)
Centrin-2
(5)
Mediator of RNA polymerase II transcription subunit 15
(5)
Mediator of RNA polymerase II transcription subunit 16
(5)
Mediator of RNA polymerase II transcription subunit 23
(5)
Mediator of RNA polymerase II transcription subunit 24
(5)
Mediator of RNA polymerase II transcription subunit 29
(5)
Unassigned peptide, likely XPB
(5)
Histone H4
(4)
Mediator of RNA polymerase II transcription subunit 1
(4)
Mediator of RNA polymerase II transcription subunit 26
(4)
RPB10
(4)
SCP-X
(4)
SCP-Y
(4)
Transcription elongation factor A protein 1
(4)
Unassigned peptide, likely TFIIE-beta
(4)
DNA (69-MER)
(3)
Mediator of RNA polymerase II transcription subunit 25
(3)
UV excision repair protein RAD23 homolog B
(3)
DNA (162-mer)
(2)
DNA (228-mer)
(2)
DNA (Ap)
(2)
DNA (Cy5)
(2)
DNA1
(2)
DNA2
(2)
More...
Interacting ligands
(1)
ZN : ZINC ION
(37)
Function and Biology
Biological function
(4)
zinc ion binding
(43)
RNA polymerase II general transcription initiation factor activity
(41)
metal ion binding
(41)
protein binding
(41)
Biological process
(9)
DNA repair
(43)
DNA-templated transcription
(43)
nucleotide-excision repair
(43)
DNA damage response
(41)
G protein-coupled receptor internalization
(41)
regulation of transcription by RNA polymerase II
(41)
response to UV
(41)
transcription by RNA polymerase II
(41)
transcription initiation at RNA polymerase II promoter
(41)
Biological cell component
(7)
transcription factor TFIIH core complex
(43)
core TFIIH complex portion of holo TFIIH complex
(41)
nuclear speck
(41)
nucleoplasm
(41)
nucleus
(41)
transcription factor TFIID complex
(41)
transcription factor TFIIH holo complex
(41)
Sequence and Structure classification
SCOP fold
(1)
Cysteine-rich domain
(1)
SCOP family
(1)
TFIIH p44 subunit cysteine-rich domain
(1)
CATH class
(1)
Alpha Beta
(2)
CATH topology
(1)
Herpes Virus-1
(2)
Pfam accession / name
(2)
PF07975 : C1_4
(43)
PF04056 : Ssl1
(42)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(1)
Diffraction radiation source type
(1)
Synchrotron
(1)
Diffraction source
(1)
SOLEIL BEAMLINE PROXIMA 1
(1)
Synchrotron site
(1)
SOLEIL
(1)
Diffraction detector type
(1)
Pixel
(1)
Refinement software
(2)
PHENIX
(4)
REFMAC
(1)
EM microscope model
(2)
FEI TITAN KRIOS
(38)
FEI TITAN
(3)
EM detector name
(3)
GATAN K3 (6k x 4k)
(19)
GATAN K2 SUMMIT (4k x 4k)
(16)
GATAN K3 BIOQUANTUM (6k x 4k)
(6)
NMR
NMR software packages
(4)
ARIA / CNS
(1)
XEASY
(1)
Xplor-NIH
(1)
XwinNMR
(1)
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 43
Select all entries on this page
Human holo-PIC in the closed state
Yan CL, Dodd T, He Y, Tainer JA, Tsutakawa SE, Ivanov I
Nat Struct Mol Biol
(2019)
[PMID: 31110295 ]
Source organisms: synthetic construct , Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-120375 (Preferred)
search this ID
Structure of the human apo TFIIH
Yan CL, Dodd T, He Y, Tainer JA, Tsutakawa SE, Ivanov I
Nat Struct Mol Biol
(2019)
[PMID: 31110295 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-148278 (Preferred)
search this ID
Cryo-EM structure of the human TFIIH core complex
Human holo-PIC in the initial transcribing state (no IIS)
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature
(2016)
[PMID: 27193682 ]
Source organism: Homo sapiens
Assembly composition: DNA/RNA/protein complex
Assembly name:
General transcription factor TFIIF complex and RNA and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118818 (Preferred)
search this ID
TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)
Chen X, Qi Y, Wang X, Wu Z, Yin X, Li J, Liu W, Xu Y
Science
(2021)
[PMID: 33958484 ]
Source organisms: Sus scrofa , Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-279019 (Preferred)
search this ID
TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)
Chen X, Qi Y, Wang X, Wu Z, Yin X, Li J, Liu W, Xu Y
Science
(2021)
[PMID: 33958484 ]
Source organisms: Sus scrofa , Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-236785 (Preferred)
search this ID
Human holo-PIC in the initial transcribing state
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature
(2016)
[PMID: 27193682 ]
Source organism: Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118817 (Preferred)
search this ID
Human holo-PIC in the closed state
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature
(2016)
[PMID: 27193682 ]
Source organism: Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118815 (Preferred)
search this ID
Human holo-PIC in the open state
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature
(2016)
[PMID: 27193682 ]
Source organism: Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
General transcription factor TFIIF complex and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118816 (Preferred)
search this ID
The cryo-EM structure of human TFIIH
Greber BJ, Nguyen THD, Fang J, Afonine PV, Adams PD, Nogales E
Nature
(2017)
[PMID: 28902838 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-148279 (Preferred)
search this ID
Entries 1 to 10 of 43