Uniprot accession / id : Q9JIQ3  OR   Uniprot accession / id : Q9NR28  OR   Uniprot accession / id : F5GYH3  OR   Uniprot accession / id : K7X1S0
 
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Entry Information
Entry status  (1)
REL
(16)
 
Experimental methods  (3)
X-ray diffraction
(11)
Electron Microscopy
(4)
Solution NMR
(1)
 
Authors  (88)
Eckelman BP
(3)
Salvesen GS
(3)
Shin H
(3)
Chai J
(2)
Deshayes K
(2)
Du C
(2)
Du J
(2)
Elliott LO
(2)
Fairbrother WJ
(2)
Fischer ES
(2)
Franklin MC
(2)
Funabiki H
(2)
Hunkeler M
(2)
Jin CY
(2)
Kadkhodayan S
(2)
Kelly AE
(2)
Nunes VA
(2)
Patel DJ
(2)
Renatus M
(2)
Sampaio CA
(2)
Sampaio CAM
(2)
Shi Y
(2)
Vucic D
(2)
Wang X
(2)
Wu JW
(2)
Ackerly H
(1)
Alexandru D
(1)
Betz SF
(1)
Bolognesi M
(1)
Cassidy CK
(1)
Clark K
(1)
Clausen T
(1)
Cornell-Kennon S
(1)
Cossu F
(1)
Das K
(1)
Deszcz L
(1)
Dietz L
(1)
Distefano MD
(1)
Ehrmann JF
(1)
Elliott PR
(1)
Ellison CJ
(1)
Felfoldi FD
(1)
Fesik SW
(1)
Flygare JA
(1)
Gogova R
(1)
Grabarczyk DB
(1)
Heinke M
(1)
Herrmann J
(1)
Hudecz O
(1)
Kessler BM
(1)
Koehn J
(1)
Kulathila R
(1)
Kurzbauer R
(1)
Kyin S
(1)
Liu Z
(1)
Malvezzi F
(1)
Mastangelo E
(1)
Mastrangelo E
(1)
Mausisa G
(1)
Meadows RP
(1)
Meinhart A
(1)
Milani M
(1)
Nayak D
(1)
Ng J
(1)
Okawa DC
(1)
Olejniczak ET
(1)
Ong D
(1)
Oost T
(1)
Pinto-Fernandez A
(1)
Pinto-Fernández A
(1)
Price A
(1)
Riechmann C
(1)
Sage D
(1)
Shulkina A
(1)
Singh S
(1)
Sivaraman J
(1)
Stams T
(1)
Suber TL
(1)
Sun C
(1)
Vachette P
(1)
Vash B
(1)
Versteeg GA
(1)
Wallweber HJ
(1)
Wallweber HJA
(1)
Wright K
(1)
Wu G
(1)
Wu J-W
(1)
Wu JC
(1)
 
Homo / hetero assembly  (2)
hetero
(13)
homo
(3)
 
Assembly composition  (2)
protein/protein complex
(13)
protein structure
(3)
 
Assembly polymer count  (5)
dimer
(6)
tetramer
(6)
dodecamer
(2)
hexamer
(1)
trimer
(1)
 
Resolution distribution
1.5 - 2
(3)
2.0 - 2.5
(5)
2.5 - 3
(4)
3.0 - 3.5
(2)
7.0 - 7.5
(1)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(7)
2005 - 2010
(1)
2010 - 2015
(3)
2015 - 2020
(2)
2020 - 2025
(4)
 
Journal  (8)
Science
(4)
Biochem J
(3)
Nature
(3)
Structure
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Biochemistry
(1)
Biophys J
(1)
J Biol Chem
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(16)
 
Organism name  (1)
Homo sapiens
(16)
 
Molecule name  (6)
Diablo IAP-binding mitochondrial protein
(16)
Diablo IAP-binding mitochondrial protein, cleaved form
(16)
Diablo homolog, mitochondrial
(16)
Direct IAP-binding protein with low pI
(16)
SMAC
(16)
Second mitochondria-derived activator of caspases
(16)
 
Molecule type  (1)
Protein
(16)
 
Gene names  (2)
DIABLO
(16)
SMAC
(16)
 
Interacting Molecules  (7)
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
(3)
Baculoviral IAP repeat-containing protein 5
(2)
Baculoviral IAP repeat-containing protein 6
(2)
Baculoviral IAP repeat-containing protein 7 30kDa subunit
(2)
Baculoviral IAP repeat-containing protein 8
(2)
E3 ubiquitin-protein ligase XIAP
(2)
Baculoviral IAP repeat-containing protein 2
(1)
 
Interacting ligands  (2)
ACT : ACETATE ION
(1)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(1)
 
Function and Biology
Biological process  (1)
apoptotic process
(8)
 
Biological cell component  (1)
mitochondrion
(8)
 
Sequence and Structure classification
SCOP fold  (1)
Spectrin repeat-like
(2)
 
SCOP family  (1)
Smac/diablo
(2)
 
CATH class  (1)
Mainly Alpha
(3)
 
CATH topology  (1)
Methane Monooxygenase Hydroxylase; Chain G, domain 1
(3)
 
Pfam accession / name  (1)
PF09057 : Smac_DIABLO
(8)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(11)
 
Diffraction radiation source type  (2)
Synchrotron
(8)
Rotating anode
(4)
 
Diffraction source  (11)
RIGAKU RU200
(2)
APS BEAMLINE 24-ID-C
(1)
APS BEAMLINE 24-ID-E
(1)
APS BEAMLINE 32-ID
(1)
CHESS BEAMLINE A1
(1)
ESRF BEAMLINE ID14-4
(1)
NSLS BEAMLINE X29A
(1)
NSLS BEAMLINE X4A
(1)
RIGAKU
(1)
RIGAKU FR-E DW
(1)
SSRL BEAMLINE BL9-1
(1)
 
Synchrotron site  (5)
APS
(3)
NSLS
(2)
CHESS
(1)
ESRF
(1)
SSRL
(1)
 
Diffraction detector type  (3)
CCD
(5)
Image plate
(5)
Pixel
(1)
 
Refinement software  (6)
PHENIX
(7)
CNS
(3)
REFMAC
(3)
phenix.real_space_refine
(2)
CNX
(1)
X-PLOR
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(4)
 
EM detector name  (3)
GATAN K3 BIOQUANTUM (6k x 4k)
(2)
FEI FALCON IV (4k x 4k)
(1)
GATAN K3 (6k x 4k)
(1)
 
NMR
NMR software packages  (1)
CNX
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 16
Entries 1 to 10 of 16
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Cryo-EM structure of BIRC6/Smac (from local refinement 1)
Hunkeler M, Fischer ES
Science (2023) [PMID: 36758104  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-274336 (Preferred)   search this ID
PDBe-KB: Q9NR28   
Electron Microscopy
3.44Å resolution
Released: 15 Feb 2023
Model geometry
Fit model/data
Data not analysed
8e2j
8e2j
8e2j
Cryo-EM structure of BIRC6/Smac
Hunkeler M, Fischer ES
Science (2023) [PMID: 36758104  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-274335 (Preferred)   search this ID
PDBe-KB: Q9NR28    Q9NR09   
Electron Microscopy
3.04Å resolution
Released: 15 Feb 2023
Model geometry
Fit model/data
Data not analysed
8e2i
8e2i
8e2i
Cryo-EM structure of human BIRC6 in complex with SMAC.
Ehrmann JF, Grabarczyk DB, Clausen T
Science (2023) [PMID: 36758105  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form and Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192525 (Preferred)   search this ID
PDBe-KB: Q9NR28    Q9NR09   
Electron Microscopy
7.2Å resolution
Released: 15 Feb 2023
Model geometry
Fit model/data
Data not analysed
8auw
8auw
8auw
Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
Dietz L, Elliott PR
Science (2023) [PMID: 36758106  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form and Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192525 (Preferred)   search this ID
PDBe-KB: Q9NR28    Q9NR09   
Electron Microscopy
3Å resolution
Released: 8 Mar 2023
Model geometry
Fit model/data
Data not analysed
8ato
8ato
8ato
Tetrameric form of Smac
Sivaraman J, Singh S, Ng J, Nayak D
J Biol Chem (2019) [PMID: 31732561  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192532 (Preferred)   search this ID
PDBe-KB: Q9NR28   
X-ray diffraction
2.805Å resolution
Released: 4 Dec 2019
Model geometry
Fit model/data
6jx6
6jx6
6jx6
NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
Nature (2000) [PMID: 11140637  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form and E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161371 (Preferred)   search this ID
PDBe-KB: Q9NR28    P98170   
Solution NMR
Released: 10 Jan 2001
Model geometry
Fit model/data
Data not deposited
1g3f
1g3f
1g3f
CRYSTAL STRUCTURE OF SMAC/DIABLO
Chai J, Shi Y
Nature (2000) [PMID: 10972280  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192531 (Preferred)   search this ID
PDBe-KB: Q9NR28   
X-ray diffraction
2.2Å resolution
Released: 13 Sep 2000
Model geometry
Fit model/data
Data not deposited
1few
1few
1few
CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN
Wu G, Chai J, Suber TL, Wu J-W, Shi Y
Nature (2000) [PMID: 11140638  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form and E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161371 (Preferred)   search this ID
PDBe-KB: Q9NR28    P98170   
X-ray diffraction
2Å resolution
Released: 10 Jan 2001
Model geometry
Fit model/data
Data not deposited
1g73
1g73
1g73
The BIR3 domain of cIAP1 in complex with the N terminal peptide from SMAC/DIABLO (AVPIAQ).
Kulathila R, Price A
Acta Crystallogr D Biol Crystallogr (2009) [PMID: 19153467  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Diablo IAP-binding mitochondrial protein, cleaved form and Baculoviral IAP repeat-containing protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171718 (Preferred)   search this ID
PDBe-KB: Q9NR28    Q13490   
X-ray diffraction
2.3Å resolution
Released: 10 Jun 2008
Model geometry
Fit model/data
3d9u
3d9u
3d9u
Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Vucic D, Deshayes K, Fairbrother WJ
Biochemistry (2003) [PMID: 12846571  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: P33    ZN    ZN    P33   
Assembly name: Baculoviral IAP repeat-containing protein 7 30kDa subunit and Diablo IAP-binding mitochondrial protein, cleaved form (Preferred)   search this complex
PDBe complex ID: PDB-CPX-188403 (Preferred)   search this ID
PDBe-KB: Q9NR28    Q96CA5   
X-ray diffraction
2.3Å resolution
Released: 26 Aug 2003
Model geometry
Fit model/data
1oxq
1oxq
1oxq
Entries 1 to 10 of 16
Entries 1 to 10 of 16