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Eckelman BP
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Jin CY
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Diablo IAP-binding mitochondrial protein
(16)
Diablo IAP-binding mitochondrial protein, cleaved form
(16)
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(16)
Direct IAP-binding protein with low pI
(16)
SMAC
(16)
Second mitochondria-derived activator of caspases
(16)
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DIABLO
(16)
SMAC
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(7)
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
(3)
Baculoviral IAP repeat-containing protein 5
(2)
Baculoviral IAP repeat-containing protein 6
(2)
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E3 ubiquitin-protein ligase XIAP
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ACT : ACETATE ION
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MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
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apoptotic process
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Methane Monooxygenase Hydroxylase; Chain G, domain 1
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PF09057 : Smac_DIABLO
(8)
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Representative Structures
Representative Structures
Entries
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Entries 1 to 10 of 16
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Cryo-EM structure of BIRC6/Smac (from local refinement 1)
Hunkeler M, Fischer ES
Science
(2023)
[PMID: 36758104 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-274336 (Preferred)
search this ID

Cryo-EM structure of BIRC6/Smac
Hunkeler M, Fischer ES
Science
(2023)
[PMID: 36758104 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-274335 (Preferred)
search this ID
Cryo-EM structure of human BIRC6 in complex with SMAC.
Ehrmann JF, Grabarczyk DB, Clausen T
Science
(2023)
[PMID: 36758105 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form and Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192525 (Preferred)
search this ID
Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
Dietz L, Elliott PR
Science
(2023)
[PMID: 36758106 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form and Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192525 (Preferred)
search this ID
Tetrameric form of Smac
Sivaraman J, Singh S, Ng J, Nayak D
J Biol Chem
(2019)
[PMID: 31732561 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192532 (Preferred)
search this ID

NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
Nature
(2000)
[PMID: 11140637 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form and E3 ubiquitin-protein ligase XIAP
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161371 (Preferred)
search this ID
CRYSTAL STRUCTURE OF SMAC/DIABLO
Chai J, Shi Y
Nature
(2000)
[PMID: 10972280 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192531 (Preferred)
search this ID

CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN
Wu G, Chai J, Suber TL, Wu J-W, Shi Y
Nature
(2000)
[PMID: 11140638 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form and E3 ubiquitin-protein ligase XIAP
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161371 (Preferred)
search this ID
The BIR3 domain of cIAP1 in complex with the N terminal peptide from SMAC/DIABLO (AVPIAQ).
Kulathila R, Price A
Acta Crystallogr D Biol Crystallogr
(2009)
[PMID: 19153467 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diablo IAP-binding mitochondrial protein, cleaved form and Baculoviral IAP repeat-containing protein 2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-171718 (Preferred)
search this ID
Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Vucic D, Deshayes K, Fairbrother WJ
Biochemistry
(2003)
[PMID: 12846571 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Baculoviral IAP repeat-containing protein 7 30kDa subunit and Diablo IAP-binding mitochondrial protein, cleaved form
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188403 (Preferred)
search this ID
Entries 1 to 10 of 16