Entry status  (1)

REL

(26)

Experimental methods  (2)

X-ray diffraction

(24)

Solution NMR

(2)

Authors  (142)

Buckbinder L

(9)

Han S

(9)

Walker DP

(9)

Aspnes GE

(8)

Bonnette PC

(7)

Brosius AD

(7)

Chang JS

(7)

Mistry A

(7)

Guibao CD

(6)

Miller DJ

(6)

Nourse A

(6)

Vanarotti MS

(6)

Zheng JJ

(6)

Chrunyk BA

(5)

Cunningham D

(5)

Griffor M

(5)

Wang H

(5)

Guzman-Perez A

(4)

Zawistoski MP

(4)

Finkelstein DB

(3)

Griffor MC

(3)

Kalgutkar AS

(3)

Klug-McLeod J

(3)

Lulo J

(3)

Lulo JE

(3)

Schlessinger J

(3)

Vanarotti M

(3)

Yuzawa S

(3)

Bagley SW

(2)

Bhattacharya SK

(2)

Boehm M

(2)

Chandrasekhar J

(2)

Cheng W

(2)

Dibrino J

(2)

Eng H

(2)

Farand J

(2)

Frederick KS

(2)

Garcia-Irizarry C

(2)

Griffith DA

(2)

Guerrero J

(2)

Guimaraes CR

(2)

Guimarães CR

(2)

Kung DW

(2)

Kwok A

(2)

Li J

(2)

Li JC

(2)

Li N

(2)

Lippa B

(2)

Loyer-Drew J

(2)

Lv Z

(2)

Mai N

(2)

McGlynn MA

(2)

Mourey R

(2)

Newby ZE

(2)

Notte GT

(2)

Phillips G

(2)

Price DA

(2)

Southers JA

(2)

Van Veldhuizen J

(2)

Venkataramani C

(2)

Wang F

(2)

Watkins WJ

(2)

Wei L

(2)

Wilbert S

(2)

Xiao J

(2)

Zablocki J

(2)

Zhao X

(2)

Zherebina Y

(2)

Arold ST

(1)

Arrowsmith CH

(1)

Autry CL

(1)

Bauman JN

(1)

Baumann A

(1)

Berglund H

(1)

Bi FC

(1)

Boer J

(1)

Bountra C

(1)

Busam RD

(1)

Chill JH

(1)

Collins R

(1)

Cooper BA

(1)

Dahlgren LG

(1)

Dunn M

(1)

Edwards AM

(1)

Flodin S

(1)

Flores A

(1)

Genna A

(1)

Gil-Henn H

(1)

Graslund S

(1)

Guibao C

(1)

Guibao CC

(1)

Hameed UFS

(1)

Hammarstrom M

(1)

Helleday T

(1)

Herman MD

(1)

Houser JA

(1)

Hulford CA

(1)

Johansson A

(1)

Johansson I

(1)

Ju C

(1)

 

More...

Homo / hetero assembly  (2)

homo

(19)

hetero

(7)

Assembly composition  (2)

protein structure

(19)

protein/protein complex

(7)

Assembly polymer count  (3)

monomer

(18)

dimer

(4)

trimer

(4)

Resolution distribution

1.5 - 2

(10)

2.0 - 2.5

(5)

2.5 - 3

(5)

3.0 - 3.5

(3)

3.5 - 4

(1)

Release year distribution

2005 - 2010

(11)

2010 - 2015

(9)

2015 - 2020

(6)

2020 - 2025

(3)

Journal  (8)

Bioorg Med Chem Lett

(6)

J Biol Chem

(5)

To be published

(4)

Biochem Biophys Res Commun

(3)

Biochemistry

(3)

J Mol Biol

(3)

Oncogene

(1)

Sci Rep

(1)

Organism superkingdom  (2)

Eukaryota

(26)

Bacteria

(1)

Organism name  (2)

Homo sapiens

(26)

Escherichia coli K-12

(1)

Molecule name  (17)

CADTK

(26)

CAK-beta

(26)

CAKB

(26)

Calcium-dependent tyrosine kinase

(26)

Calcium-regulated non-receptor proline-rich tyrosine kinase

(26)

Cell adhesion kinase beta

(26)

FADK 2

(26)

Focal adhesion kinase 2

(26)

Proline-rich tyrosine kinase 2

(26)

Protein-tyrosine kinase 2-beta

(26)

RAFTK

(26)

Related adhesion focal tyrosine kinase

(26)

MBP

(1)

MMBP

(1)

Maltodextrin-binding protein

(1)

Maltose-binding protein

(1)

Maltose/maltodextrin-binding periplasmic protein

(1)

Molecule type  (1)

Protein

(26)

Gene names  (7)

FAK2

(26)

PTK2B

(26)

PYK2

(26)

RAFTK

(26)

JW3994

(1)

b4034

(1)

malE

(1)

Interacting Molecules  (3)

Leupaxin

(3)

Paxillin

(3)

Src substrate cortactin

(1)

Interacting ligands  (17)

PO4 : PHOSPHATE ION

(2)

SO4 : SULFATE ION

(2)

YAM : N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

(2)

0YH : 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1H-pyrazol-5-yl]urea

(1)

0YJ : 7-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)-N-(propan-2-yl)-1H-indole-2-carboxamide

(1)

349 : 5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2H-indol-2-one

(1)

3JZ : N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide

(1)

4JZ : 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3H-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1H-pyrazol-5-yl}urea

(1)

7FM : 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one

(1)

AGS : PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER

(1)

B96 : 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA

(1)

EDO : 1,2-ETHANEDIOL

(1)

GLC : alpha-D-glucopyranose

(1)

GOL : GLYCEROL

(1)

MG : MAGNESIUM ION

(1)

P1E : 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide

(1)

PRD_900001 : alpha-maltose

(1)

EC number / name  (1)

2.7.10.2 : Non-specific protein-tyrosine kinase

(26)

Biological function  (6)

protein tyrosine kinase activity

(23)

ATP binding

(14)

protein kinase activity

(14)

carbohydrate transmembrane transporter activity

(1)

maltose binding

(1)

protein binding

(1)

Biological process  (10)

protein phosphorylation

(23)

signal complex assembly

(9)

DNA damage response

(1)

carbohydrate transmembrane transport

(1)

carbohydrate transport

(1)

cell chemotaxis

(1)

detection of maltose stimulus

(1)

maltodextrin transmembrane transport

(1)

maltose transport

(1)

transmembrane transport

(1)

Biological cell component  (8)

focal adhesion

(9)

ATP-binding cassette (ABC) transporter complex

(1)

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

(1)

cytoskeleton

(1)

maltose transport complex

(1)

membrane

(1)

outer membrane-bounded periplasmic space

(1)

periplasmic space

(1)

CATH class  (3)

Mainly Alpha

(22)

Alpha Beta

(13)

Mainly Beta

(1)

CATH topology  (6)

Phosphorylase Kinase; domain 1

(12)

Transferase(Phosphotransferase); domain 1

(12)

Four Helix Bundle (Hemerythrin (Met), subunit A)

(9)

Acyl-CoA Binding Protein

(1)

PH-domain like

(1)

Ubiquitin-like (UB roll)

(1)

Pfam accession / name  (6)

PF07714 : PK_Tyr_Ser-Thr

(14)

PF03623 : Focal_AT

(9)

PF00373 : FERM_M

(1)

PF01547 : SBP_bac_1

(1)

PF18038 : FERM_N_2

(1)

PF21477 : FERM_C_FAK1

(1)

Diffraction protocol  (2)

Single wavelength

(23)

MAD

(1)

Diffraction radiation source type  (2)

Synchrotron

(22)

Rotating anode

(2)

Diffraction source  (10)

APS BEAMLINE 17-ID

(7)

APS BEAMLINE 22-BM

(3)

APS BEAMLINE 22-ID

(3)

NSLS BEAMLINE X29A

(3)

ALS BEAMLINE 5.0.2

(2)

RIGAKU RU200

(2)

AUSTRALIAN SYNCHROTRON BEAMLINE MX2

(1)

ESRF BEAMLINE ID29

(1)

SOLEIL BEAMLINE PROXIMA 2

(1)

SPRING-8 BEAMLINE BL45XU

(1)

Synchrotron site  (7)

APS

(13)

NSLS

(3)

ALS

(2)

Australian Synchrotron

(1)

ESRF

(1)

SOLEIL

(1)

SPring-8

(1)

Diffraction detector type  (3)

CCD

(19)

Pixel

(3)

Image plate

(2)

Refinement software  (5)

REFMAC

(13)

PHENIX

(7)

BUSTER

(2)

BUSTER-TNT

(1)

CNS

(1)

NMR software packages  (4)

CNS

(1)

CYANA

(1)

TALOS+

(1)

TopSpin

(1)

NMR Field Strength

500.0 - 600

(1)

600.0 - 700

(2)

700.0 - 800

(2)

800.0 - 900

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%