Uniprot accession / id : Q9QXV1  OR   Uniprot accession / id : Q9HC52  OR   Uniprot accession / id : C9JM54
 
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REL
(4)
 
Experimental methods  (2)
Solution NMR
(2)
X-ray diffraction
(2)
 
Authors  (52)
Arrowsmith CH
(2)
Bountra C
(2)
Edwards AM
(2)
Min J
(2)
Structural Genomics Consortium (SGC)
(2)
Vedadi M
(2)
Amaya M
(1)
Amaya MF
(1)
Baughman BM
(1)
Bedford MT
(1)
Black K
(1)
Bochkarev A
(1)
Brown PJ
(1)
Bushweller JH
(1)
Cheng N
(1)
Cholensky SH
(1)
Dickson BM
(1)
Duan S
(1)
Frye SV
(1)
Hirota H
(1)
Huang XP
(1)
Huber KG
(1)
James LI
(1)
Kaustov L
(1)
Kigawa T
(1)
Kozieradzki I
(1)
Kuntimaddi A
(1)
Leach BI
(1)
Lemak A
(1)
Li F
(1)
Li Z
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Liu Y
(1)
Loppnau P
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Nady N
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Norris JL
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Ouyang H
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Pattenden SG
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Qin S
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RIKEN Structural Genomics/Proteomics Initiative (RSGI)
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Ravichandran M
(1)
Roth BL
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Ruhul Momen AZM
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Sagum C
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Schapira M
(1)
Senisterra G
(1)
Stuckey JI
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Tempel W
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Tomizawa T
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Walker JR
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Wasney GA
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Weigelt J
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Yokoyama S
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Homo / hetero assembly  (2)
hetero
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homo
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protein/protein complex
(3)
protein structure
(1)
 
Assembly polymer count  (2)
dimer
(3)
monomer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(1)
 
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2005 - 2010
(2)
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To be published
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(1)
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Macromolecules
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Eukaryota
(4)
 
Organism name  (2)
Homo sapiens
(3)
Mus musculus
(1)
 
Molecule name  (6)
Chromobox protein homolog 8
(4)
Pc3
(4)
Polycomb 3 homolog
(4)
Rectachrome 1
(3)
hPc3
(3)
mPc3
(1)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (5)
CBX8
(3)
PC3
(3)
RC1
(3)
Cbx8
(1)
Pc3
(1)
 
Interacting Molecules  (3)
H3K9 peptide
(1)
Protein AF-9
(1)
unc3866
(1)
 
Sequence and Structure classification
SCOP fold  (1)
SH3-like barrel
(1)
 
SCOP family  (1)
Chromo domain
(1)
 
CATH class  (1)
Mainly Beta
(2)
 
CATH topology  (1)
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
(2)
 
Pfam accession / name  (1)
PF00385 : Chromo
(3)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
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Synchrotron
(2)
 
Diffraction source  (2)
APS BEAMLINE 19-ID
(1)
CLSI BEAMLINE 08ID-1
(1)
 
Synchrotron site  (2)
APS
(1)
CLSI
(1)
 
Diffraction detector type  (1)
CCD
(2)
 
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Crystal Structure of chromodomain of CBX8 in complex with inhibitor UNC3866
Liu Y, Tempel W, Walker JR, Stuckey JI, Dickson BM, James LI, Frye SV, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)
Nat Chem Biol (2016) [PMID: 26807715  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: 5R0    5R5    5R5    ELY    ELY   
Assembly name: Chromobox protein homolog 8 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-165611 (Preferred)   search this ID
PDBe-KB: Q9HC52   
X-ray diffraction
1.18Å resolution
Released: 23 Dec 2015
Model geometry
Fit model/data
5eq0
5eq0
5eq0
Crystal structure of human chromobox homolog 8 (CBX8) with H3K9 peptide
Amaya MF, Ravichandran M, Loppnau P, Kozieradzki I, Edwards AM, Arrowsmith CH, Weigelt J, Bountra C, Bochkarev A, Min J, Ouyang H, Structural Genomics Consortium (SGC)
J Biol Chem (2011) [PMID: 21047797  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: M3L    M3L   
Assembly name: Chromobox protein homolog 8 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163647 (Preferred)   search this ID
PDBe-KB: Q9HC52   
X-ray diffraction
1.55Å resolution
Released: 8 Sep 2009
Model geometry
Fit model/data
3i91
3i91
3i91
Solution Structure of RSGI RUH-055, a Chromo Domain from Mus musculus cDNA
Ruhul Momen AZM, Hirota H, Tomizawa T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Chromobox protein homolog 8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193046 (Preferred)   search this ID
PDBe-KB: Q9QXV1   
Solution NMR
Released: 26 Oct 2006
Model geometry
Fit model/data
Data not analysed
2dnv
2dnv
2dnv
Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)
Kuntimaddi A, Leach BI, Bushweller JH
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Chromobox protein homolog 8 and Protein AF-9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154679 (Preferred)   search this ID
PDBe-KB: Q9HC52    P42568   
Solution NMR
Released: 20 Jul 2016
Model geometry
Fit model/data
Data not analysed
2n4q
2n4q
2n4q
Entries 1 to 4 of 4
Entries 1 to 4 of 4