Uniprot accession / id : Q9R1P4  OR   Uniprot accession / id : P25786  OR   Uniprot accession / id : F5H112
 
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Entry Information
Entry status  (1)
REL
(120)
 
Experimental methods  (2)
Electron Microscopy
(100)
X-ray diffraction
(20)
 
Authors  (334)
Mao Y
(32)
Lu Y
(27)
Finley D
(25)
Zhu Y
(23)
Ouyang Q
(20)
Wu Z
(20)
Zhang S
(20)
Wang WL
(14)
Chen S
(13)
Yin D
(13)
Zhang H
(13)
Zhao L
(13)
Zou S
(13)
Chari A
(12)
Henneberg F
(12)
Wang Y
(12)
Zhao J
(12)
Zhou C
(12)
Arkinson C
(11)
Dong KC
(11)
Gee CL
(11)
Martin A
(11)
Schrader J
(11)
Stark H
(11)
Bourenkov G
(10)
Mata R
(10)
Mata RA
(10)
Schneider TR
(10)
Tittmann K
(10)
Huang L
(9)
Wang X
(9)
Zhang Z
(9)
Cheng Y
(8)
Colson L
(8)
Goldberg AL
(8)
Huang B
(8)
Lee D
(8)
Makhija S
(8)
Muralidharan M
(8)
Tkacik E
(8)
Adolf F
(7)
Dong Y
(7)
Du J
(7)
Goodall EA
(7)
Hanna J
(7)
Hanna JW
(7)
Harper JW
(7)
Li X
(7)
Mao YD
(7)
Rawson S
(7)
Rawson SD
(7)
Schulman BA
(7)
Stoilova-McPhie S
(7)
Walsh Jr RM
(7)
Walsh RM
(7)
Wu J
(7)
Yu D
(7)
von Gronau S
(7)
Finley DJ
(5)
Kirschner MW
(5)
Lee BH
(5)
Ma YB
(5)
Yu Z
(5)
Basler M
(4)
Draczkowski P
(4)
Groettrup M
(4)
Groll M
(4)
Heinemeyer W
(4)
Hsu STD
(4)
Huber E
(4)
Huber EM
(4)
Kirk C
(4)
Kirk CJ
(4)
Mohammad Z
(4)
Schwab R
(4)
Wang YS
(4)
Brik A
(3)
Cong Y
(3)
Day S
(3)
Ding Z
(3)
Glickman MH
(3)
Han Q
(3)
Han Y
(3)
Kleifeld O
(3)
Liu K
(3)
Mali SM
(3)
Morag R
(3)
Rozenberg A
(3)
Sahoo MP
(3)
Sahu I
(3)
Singh SK
(3)
Sulkshane P
(3)
Tang Q
(3)
Xu C
(3)
Zhang Y
(3)
Arai Y
(2)
Baumeister W
(2)
Beck F
(2)
Busch M
(2)
Chen X
(2)
 
More...
 
Homo / hetero assembly  (1)
hetero
(120)
 
Assembly composition  (1)
protein/protein complex
(120)
 
Assembly polymer count  (22)
28-mer
(35)
46-mer
(15)
48-mer
(10)
34-mer
(7)
47-mer
(7)
49-mer
(7)
32-mer
(6)
29-mer
(5)
30-mer
(5)
27-mer
(4)
tridecamer
(4)
35-mer
(3)
64-mer
(2)
heptadecamer
(2)
21-mer
(1)
25-mer
(1)
33-mer
(1)
42-mer
(1)
dodecamer
(1)
hexadecamer
(1)
pentadecamer
(1)
undecamer
(1)
 
Resolution distribution
1.5 - 2
(5)
2.0 - 2.5
(10)
2.5 - 3
(32)
3.0 - 3.5
(33)
3.5 - 4
(19)
4.0 - 4.5
(10)
4.5 - 5
(4)
5.5 - 6
(2)
6.5 - 7
(3)
7.5 - 8
(2)
 
Release year distribution
2010 - 2015
(7)
2015 - 2020
(46)
2020 - 2025
(74)
2025 - 2030
(5)
 
Journal  (17)
Nature
(21)
Nat Commun
(19)
Proc Natl Acad Sci U S A
(16)
Mol Cell
(10)
Science
(10)
bioRxiv
(10)
Nat Struct Mol Biol
(9)
To be published
(6)
Cell
(4)
Structure
(4)
Sci Adv
(3)
Bioorg Med Chem
(2)
J Med Chem
(2)
ACS Chem Biol
(1)
Mol Cancer Ther
(1)
Mol Cell Proteomics
(1)
PLoS Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(120)
 
Organism name  (2)
Homo sapiens
(114)
Mus musculus
(6)
 
Molecule name  (9)
Macropain subunit C2
(120)
Multicatalytic endopeptidase complex subunit C2
(120)
Proteasome component C2
(120)
Proteasome nu chain
(120)
Proteasome subunit alpha type-1
(120)
Proteasome subunit alpha-6
(120)
alpha-6
(120)
30 kDa prosomal protein
(114)
PROS-30
(114)
 
Molecule type  (1)
Protein
(120)
 
Gene names  (6)
HC2
(114)
NU
(114)
PROS30
(114)
PSC2
(114)
PSMA1
(114)
Psma1
(6)
 
Interacting Molecules  (65)
Proteasome subunit alpha type-2
(120)
Proteasome subunit alpha type-3
(120)
Proteasome subunit alpha type-4
(120)
Proteasome subunit alpha type-5
(120)
Proteasome subunit alpha type-6
(120)
Proteasome subunit alpha type-7
(120)
Proteasome subunit beta type-3
(106)
Proteasome subunit beta type-2
(105)
Proteasome subunit beta type-7
(105)
Proteasome subunit beta type-1
(102)
Proteasome subunit beta type-4
(101)
Proteasome subunit beta type-5
(96)
Proteasome subunit beta type-6
(95)
26S proteasome regulatory subunit 4
(62)
26S proteasome regulatory subunit 6A
(62)
26S proteasome regulatory subunit 6B
(62)
26S proteasome regulatory subunit 7
(62)
26S proteasome regulatory subunit 8
(62)
26S proteasome non-ATPase regulatory subunit 1
(61)
26S proteasome non-ATPase regulatory subunit 11
(61)
26S proteasome non-ATPase regulatory subunit 12
(61)
26S proteasome non-ATPase regulatory subunit 13
(61)
26S proteasome non-ATPase regulatory subunit 14
(61)
26S proteasome non-ATPase regulatory subunit 3
(61)
26S proteasome non-ATPase regulatory subunit 4
(61)
26S proteasome non-ATPase regulatory subunit 6
(61)
26S proteasome non-ATPase regulatory subunit 7
(61)
26S proteasome non-ATPase regulatory subunit 8
(61)
26S proteasome non-ATPase regulatory subunit 2
(59)
26S proteasome complex subunit SEM1
(57)
26S proteasome regulatory subunit 10B
(48)
Ubiquitin
(21)
AAA+ ATPase domain-containing protein
(14)
Ubiquitin carboxyl-terminal hydrolase 14
(14)
Proteasome assembly chaperone 1
(13)
Proteasome assembly chaperone 2
(13)
Proteasome maturation protein
(11)
Thioredoxin-like protein 1
(8)
NEDD8 ultimate buster 1
(7)
Substrate
(7)
Proteasome subunit beta type-10
(6)
Proteasome subunit beta type-8
(6)
Proteasome subunit beta type-9
(6)
substrate
(6)
substrate peptide
(5)
Proteasome activator complex subunit 4
(4)
Proteasome activator complex subunit 1
(3)
Proteasome activator complex subunit 2
(3)
Sem1
(3)
bound Oprozomib
(3)
Proteasome assembly chaperone 3
(2)
Proteasome assembly chaperone 4
(2)
AN1-type zinc finger protein 5
(1)
ARG-SER-TYR-TYR-SER
(1)
Akirin-2
(1)
EPOXOMICIN (peptide inhibitor)
(1)
Green to red photoconvertible GFP-like protein EosFP
(1)
Proteasome activator PA28 C-terminal domain-containing protein
(1)
Proteasome subunit alpha type-1
(1)
Protein SIC1
(1)
Substrate polypeptide
(1)
UBA domain-containing protein
(1)
Ubiquitin D
(1)
Z-LLY-ketoaldehyde peptide
(1)
sem1
(1)
 
Interacting ligands  (5)
CL : CHLORIDE ION
(11)
K : POTASSIUM ION
(2)
NEN : 1-ETHYL-PYRROLIDINE-2,5-DIONE
(2)
IOD : IODIDE ION
(1)
SCN : THIOCYANATE ION
(1)
 
Function and Biology
EC number / name  (1)
3.4.25.1 : Proteasome endopeptidase complex
(82)
 
Biological function  (2)
lipopolysaccharide binding
(120)
protein binding
(120)
 
Biological process  (5)
immune system process
(120)
negative regulation of inflammatory response to antigenic stimulus
(120)
proteasome-mediated ubiquitin-dependent protein catabolic process
(114)
proteolysis involved in protein catabolic process
(112)
ubiquitin-dependent protein catabolic process
(112)
 
Biological cell component  (9)
centrosome
(120)
cytoplasm
(120)
cytosol
(120)
nucleoplasm
(120)
nucleus
(120)
proteasome complex
(120)
proteasome core complex
(120)
proteasome core complex, alpha-subunit complex
(120)
extracellular exosome
(114)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(20)
 
CATH topology  (1)
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
(20)
 
Pfam accession / name  (2)
PF00227 : Proteasome
(120)
PF10584 : Proteasome_A_N
(120)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(20)
 
Diffraction radiation source type  (1)
Synchrotron
(20)
 
Diffraction source  (6)
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
(11)
SLS BEAMLINE X06SA
(3)
APS BEAMLINE 19-ID
(2)
SLS BEAMLINE X06DA
(2)
DIAMOND BEAMLINE I02
(1)
DIAMOND BEAMLINE I24
(1)
 
Synchrotron site  (4)
PETRA III, EMBL c/o DESY
(11)
SLS
(5)
APS
(2)
Diamond
(2)
 
Diffraction detector type  (2)
Pixel
(16)
CCD
(4)
 
Refinement software  (4)
PHENIX
(41)
REFMAC
(17)
phenix.real_space_refine
(8)
BUSTER
(2)
 
EM microscope model  (8)
FEI TITAN KRIOS
(65)
FEI TECNAI ARCTICA
(12)
TFS KRIOS
(11)
FEI POLARA 300
(5)
FEI TECNAI 12
(3)
TFS GLACIOS
(2)
FEI TALOS ARCTICA
(1)
JEOL 3200FS
(1)
 
EM detector name  (7)
GATAN K2 SUMMIT (4k x 4k)
(48)
GATAN K3 (6k x 4k)
(26)
GATAN K2 QUANTUM (4k x 4k)
(9)
GATAN K3 BIOQUANTUM (6k x 4k)
(9)
FEI FALCON II (4k x 4k)
(5)
FEI FALCON III (4k x 4k)
(2)
OTHER
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 120
Entries 1 to 10 of 120
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mouse proteasome 20S subunit in complex with compound 1
Kashima A, Arai Y
Bioorg Med Chem (2024) [PMID: 38906067  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: A1L0C   
Assembly name: Proteasome core complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126710 (Preferred)   search this ID
PDBe-KB: Q9R1P4    Q60692    Q9QUM9    P99026    Q9Z2U1    O70435    (view 8 more)
Electron Microscopy
2.7Å resolution
Released: 31 Jul 2024
Model geometry
Fit model/data
Data not analysed
8ypk
8ypk
8ypk
Human proteasome alpha ring assembly intermediate
Zhang H, Zhao J
Nat Commun (2024) [PMID: 39294158  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: PSMG1-PSMG2 proteasomal chaperone complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279324 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    Q969U7    Q9BT73    O95456    (view 5 more)
Electron Microscopy
3Å resolution
Released: 23 Oct 2024
Model geometry
Fit model/data
Data not analysed
8tm3
8tm3
8tm3
Human mixed 13S proteasome assembly intermediate
Zhang H, Zhao J
Nat Commun (2024) [PMID: 39294158  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: PSMG1-PSMG2 proteasomal chaperone complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-271558 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    Q969U7    Q99436    P49720    (view 7 more)
Electron Microscopy
3Å resolution
Released: 23 Oct 2024
Model geometry
Fit model/data
Data not analysed
8tm5
8tm5
8tm5
Human pre 13S proteasome assembly intermediate
Zhang H, Zhao J
Nat Commun (2024) [PMID: 39294158  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: PSMG1-PSMG2 proteasomal chaperone complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-271558 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    Q969U7    Q99436    P49720    (view 7 more)
Electron Microscopy
3Å resolution
Released: 23 Oct 2024
Model geometry
Fit model/data
Data not analysed
8tm4
8tm4
8tm4
Cryo-EM structure of human proteasome assembly intermediate half-proteasome
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) [PMID: 39792683  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: PSMG1-PSMG2 proteasomal chaperone complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-271556 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    Q969U7    Q99436    P49720    (view 11 more)
Electron Microscopy
2.91Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
8yix
8yix
8yix
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid
Musil D, Klein M
Mol Cancer Ther (2021) [PMID: 34045234  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: S5K    NA    SCN    NA   
Assembly name: 20S immunoproteasome complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127163 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    P40306    P28065    P49720    (view 8 more)
X-ray diffraction
2.288Å resolution
Released: 9 Jun 2021
Model geometry
Fit model/data
7awe
7awe
7awe
canine immunoproteasome 20S subunit in complex with compound 1
Kashima A, Arai Y
Bioorg Med Chem (2024) [PMID: 38906067  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: THR    A1L0D    THR   
Assembly name: Proteasome core complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126710 (Preferred)   search this ID
PDBe-KB: Q9R1P4    Q60692    Q9QUM9    P99026    Q9Z2U1    O70435    (view 8 more)
Electron Microscopy
2.5Å resolution
Released: 31 Jul 2024
Model geometry
Fit model/data
Data not analysed
8yvp
8yvp
8yvp
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid
Musil D, Klein M, Crosignani S
J Med Chem (2021) [PMID: 34228444  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SKN    NA    SO4    NA   
Assembly name: 20S immunoproteasome complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127163 (Preferred)   search this ID
PDBe-KB: P25786    P25789    P25788    P40306    P28070    P28065    (view 8 more)
X-ray diffraction
2.43Å resolution
Released: 1 Dec 2021
Model geometry
Fit model/data
7b12
7b12
7b12
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Mao YD
Nature (2019) [PMID: 30479383  ]
Assembly composition: protein/protein complex
Bound ligands: MG    ZN    ADP    ADP    ZN    ATP    MG    ATP   
Assembly name: 20S proteasome complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126177 (Preferred)   search this ID
PDBe-KB: P25786    P43686    P25789    O43242    Q9UNM6    P48556    (view 28 more)
Electron Microscopy
3.5Å resolution
Released: 21 Nov 2018
Model geometry
Fit model/data
Data not analysed
6msg
6msg
6msg
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Mao YD
Nature (2019) [PMID: 30479383  ]
Assembly composition: protein/protein complex
Bound ligands: MG    ZN    ADP    ADP    ZN    ATP    MG    ATP   
Assembly name: Proteasome complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126179 (Preferred)   search this ID
PDBe-KB: P25786    P43686    P25789    O43242    Q9UNM6    P48556    (view 27 more)
Electron Microscopy
3.3Å resolution
Released: 21 Nov 2018
Model geometry
Fit model/data
Data not analysed
6msj
6msj
6msj
...
Entries 1 to 10 of 120
Entries 1 to 10 of 120