Uniprot accession / id : (Q9UJM3)
 
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Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (1)
X-ray diffraction
(7)
 
Authors  (34)
Beroukhim R
(3)
Bose R
(3)
Cho A
(3)
Cho J
(3)
Cole PA
(3)
Eck MJ
(3)
Ficarro SB
(3)
Jura N
(3)
Kim K
(3)
Kim N
(3)
Kuriyan J
(3)
Lee BI
(3)
Marto JA
(3)
Meyerson M
(3)
Murray B
(3)
Park AK
(3)
Park AKJ
(3)
Park E
(3)
Park WY
(3)
Pickin KA
(3)
Zhang X
(3)
Zhang Y
(3)
Beroukim R
(2)
Park A
(2)
Yi Z
(2)
Brodsky O
(1)
Feng J
(1)
Ferre R
(1)
Gajiwala KS
(1)
Kath JC
(1)
Lee B
(1)
Ryan K
(1)
Stewart A
(1)
Weinrich S
(1)
 
Homo / hetero assembly  (1)
hetero
(7)
 
Assembly composition  (1)
protein/protein complex
(7)
 
Assembly polymer count  (1)
dimer
(7)
 
Resolution distribution
2.5 - 3
(3)
3.0 - 3.5
(3)
3.5 - 4
(1)
 
Release year distribution
2005 - 2010
(3)
2010 - 2015
(4)
2015 - 2020
(3)
 
Journal  (3)
Nat Struct Mol Biol
(3)
Nature
(3)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (1)
Homo sapiens
(7)
 
Molecule name  (6)
ERBB receptor feedback inhibitor 1
(7)
Epidermal growth factor receptor
(7)
MIG-6
(7)
Mitogen-inducible gene 6 protein
(7)
Proto-oncogene c-ErbB-1
(7)
Receptor tyrosine-protein kinase erbB-1
(7)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (6)
EGFR
(7)
ERBB
(7)
ERBB1
(7)
ERRFI1
(7)
HER1
(7)
MIG6
(7)
 
Interacting Molecules  (2)
ERBB receptor feedback inhibitor 1
(7)
Epidermal growth factor receptor
(7)
 
Interacting ligands  (1)
SO4 : SULFATE ION
(1)
 
Function and Biology
EC number / name  (1)
2.7.10.1 : Receptor protein-tyrosine kinase
(7)
 
Biological function  (3)
ATP binding
(7)
protein kinase activity
(7)
protein tyrosine kinase activity
(7)
 
Biological process  (1)
protein phosphorylation
(7)
 
Representative Structures
Representative Structures
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Entries 1 to 7 of 7
Entries 1 to 7 of 7
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Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J
Nature (2007) [PMID: 18046415  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
2.9Å resolution
Released: 4 Dec 2007
Model geometry
Fit model/data
2rfe
2rfe
2rfe
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J
Nature (2007) [PMID: 18046415  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
3.5Å resolution
Released: 4 Dec 2007
Model geometry
Fit model/data
2rf9
2rf9
2rf9
Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide
Gajiwala KS, Feng J, Ferre R, Ryan K, Brodsky O, Stewart A
Structure (2013) [PMID: 23273428  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
3.37Å resolution
Released: 16 Jan 2013
Model geometry
Fit model/data
4i21
4i21
4i21
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Eck MJ, Park E, Lee B
Nat Struct Mol Biol (2015) [PMID: 26280531  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: PTR    PTR   
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
2.7Å resolution
Released: 12 Aug 2015
Model geometry
Fit model/data
4zjv
4zjv
4zjv
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J
Nature (2007) [PMID: 18046415  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
3.6Å resolution
Released: 4 Dec 2007
Model geometry
Fit model/data
2rfd
2rfd
2rfd
Crystal structures of EGFR in complex with Mig6
Park E, Kim N, Yi Z, Cho A, Kim K, Ficarro SB, Park A, Park WY, Murray B, Meyerson M, Beroukim R, Marto JA, Cho J, Eck MJ
Nat Struct Mol Biol (2015) [PMID: 26280531  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: PTR    PTR   
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
2.905Å resolution
Released: 12 Aug 2015
Model geometry
Fit model/data
4r3p
4r3p
4r3p
Crystal structures of EGFR in complex with Mig6
Park E, Kim N, Yi Z, Cho A, Kim K, Ficarro SB, Park A, Park WY, Murray B, Meyerson M, Beroukim R, Marto JA, Cho J, Eck MJ
Nat Struct Mol Biol (2015) [PMID: 26280531  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: PTR    PTR   
Assembly name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132685 (Preferred)   search this ID
PDBe-KB: P00533    Q9UJM3   
X-ray diffraction
3.25Å resolution
Released: 12 Aug 2015
Model geometry
Fit model/data
4r3r
4r3r
4r3r
Entries 1 to 7 of 7
Entries 1 to 7 of 7