Uniprot accession / id : Q9WTK5  OR   Uniprot accession / id : Q00653
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (2)
X-ray diffraction
(12)
Solution NMR
(1)
 
Authors  (39)
Ghosh G
(8)
Huang DB
(4)
Li T
(4)
Meshcheryakov VA
(4)
Pan W
(4)
Wang VY
(4)
Wang VY-F
(4)
Wang Y
(4)
Vu D
(3)
Forwood JK
(2)
Fusco A
(2)
Stewart M
(2)
Tsimbslyuk S
(2)
Bharath SR
(1)
Bowler MW
(1)
Cramer P
(1)
Duynne GV
(1)
Gupta K
(1)
Hayashi F
(1)
Larson CJ
(1)
Li Y
(1)
Loo BZL
(1)
Miller D
(1)
Muller CW
(1)
Müller CW
(1)
Nagashima T
(1)
Ozturk MB
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Song H
(1)
Tao Z
(1)
Tao ZH
(1)
Tergaonkar V
(1)
Van Duyne GD
(1)
Vemu A
(1)
Verdine GL
(1)
Ware CF
(1)
Xu X
(1)
Yokoyama S
(1)
Young Kim D
(1)
 
Homo / hetero assembly  (2)
hetero
(10)
homo
(3)
 
Assembly composition  (3)
DNA/protein complex
(7)
protein structure
(3)
protein/protein complex
(3)
 
Assembly polymer count  (4)
tetramer
(7)
dimer
(4)
monomer
(1)
trimer
(1)
 
Resolution distribution
2.0 - 2.5
(2)
2.5 - 3
(6)
3.0 - 3.5
(4)
 
Release year distribution
1995 - 2000
(1)
2005 - 2010
(4)
2010 - 2015
(3)
2015 - 2020
(2)
2020 - 2025
(6)
 
Journal  (6)
To be published
(5)
Elife
(4)
EMBO J
(1)
J Mol Biol
(1)
Nat Commun
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (2)
Homo sapiens
(11)
Mus musculus
(2)
 
Molecule name  (8)
DNA-binding factor KBF2
(13)
Nuclear factor NF-kappa-B p100 subunit
(13)
Nuclear factor NF-kappa-B p52 subunit
(13)
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
(13)
H2TF1
(11)
Lymphocyte translocation chromosome 10 protein
(11)
Lyt10
(11)
Oncogene Lyt-10
(11)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (3)
LYT10
(11)
NFKB2
(11)
Nfkb2
(2)
 
Interacting Molecules  (17)
Importin subunit alpha-1
(2)
Transcription factor RelB
(2)
5'-D(*DCP*DGP*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DC)-3'
(1)
DNA (5'-D(*AP*AP*GP*GP*GP*GP*GP*AP*GP*TP*CP*CP*CP*CP*TP*TP*G)-3')
(1)
DNA (5'-D(*AP*GP*GP*GP*GP*TP*TP*AP*CP*CP*CP*CP*C)-3')
(1)
DNA (5'-D(*CP*AP*AP*GP*GP*GP*GP*AP*CP*TP*CP*CP*CP*CP*CP*TP*T)-3')
(1)
DNA (5'-D(*CP*AP*AP*GP*GP*GP*GP*TP*CP*AP*CP*CP*CP*CP*CP*TP*TP*C)-3')
(1)
DNA (5'-D(*CP*AP*AP*GP*GP*GP*GP*TP*TP*AP*CP*CP*CP*CP*CP*TP*T)-3')
(1)
DNA (5'-D(*GP*AP*AP*GP*GP*GP*GP*GP*TP*AP*AP*CP*CP*CP*CP*TP*TP*G)-3')
(1)
DNA (5'-D(*GP*AP*AP*GP*GP*GP*GP*GP*TP*GP*AP*CP*CP*CP*CP*TP*TP*G)-3')
(1)
DNA (5'-D(*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*C)-3')
(1)
DNA (5'-D(*GP*GP*GP*GP*AP*TP*TP*CP*CP*CP*C)-3')
(1)
DNA (5'-D(*GP*GP*GP*GP*GP*TP*AP*AP*CP*CP*CP*CP*T)-3')
(1)
DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3')
(1)
DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3')
(1)
Protein C-ets-1
(1)
bacterial peptide
(1)
 
Interacting ligands  (1)
SO4 : SULFATE ION
(2)
 
Function and Biology
Biological function  (2)
DNA-binding transcription factor activity
(9)
DNA binding
(7)
 
Biological process  (2)
regulation of DNA-templated transcription
(9)
signal transduction
(1)
 
Biological cell component  (1)
cytoplasm
(9)
 
Sequence and Structure classification
SCOP fold  (2)
Common fold of diphtheria toxin/transcription factors/cytochrome f
(1)
Immunoglobulin-like beta-sandwich
(1)
 
SCOP family  (2)
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
(1)
Rel/Dorsal transcription factors, DNA-binding domain
(1)
 
CATH class  (2)
Mainly Beta
(5)
Mainly Alpha
(1)
 
CATH topology  (2)
Immunoglobulin-like
(5)
Death Domain, Fas
(1)
 
Pfam accession / name  (4)
PF16179 : RHD_dimer
(9)
PF00554 : RHD_DNA_bind
(7)
PF00023 : Ank
(1)
PF00531 : Death
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(12)
 
Diffraction radiation source type  (2)
Synchrotron
(10)
Rotating anode
(2)
 
Diffraction source  (8)
SSRF BEAMLINE BL17U1
(3)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(2)
RIGAKU RU200
(2)
APS BEAMLINE 19-ID
(1)
APS BEAMLINE 24-ID-C
(1)
ESRF BEAMLINE BM14
(1)
ESRF BEAMLINE MASSIF-1
(1)
SSRF BEAMLINE BL19U1
(1)
 
Synchrotron site  (4)
SSRF
(4)
APS
(2)
Australian Synchrotron
(2)
ESRF
(2)
 
Diffraction detector type  (3)
Pixel
(7)
Image plate
(3)
CCD
(2)
 
Refinement software  (4)
REFMAC
(5)
CNS
(4)
PHENIX
(2)
X-PLOR
(1)
 
NMR
NMR software packages  (5)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
VNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
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Monopartite p52 NLS in complex with Importin alpha 2
Tsimbslyuk S, Stewart M, Forwood JK
To be published
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-273854 (Preferred)   search this ID
PDBe-KB: Q00653    P52293   
X-ray diffraction
2.6Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
8g8q
8g8q
8g8q
Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2
Xu X, Bharath SR, Song H
Nat Commun (2018) [PMID: 30093619  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: Nuclear factor NF-kappa-B p52 subunit and Protein C-ets-1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-119521 (Preferred)   search this ID
PDBe-KB: Q00653    P14921   
X-ray diffraction
2.99Å resolution
Released: 19 Sep 2018
Model geometry
Fit model/data
5zmc
5zmc
5zmc
Structure of NF-kB p52 homodimer bound to A/T-centric P-Selectin kB DNA fragment
Meshcheryakov VA, Wang VY-F
Elife (2023) [PMID: 36779700  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p52/p52 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-122243 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
3.1Å resolution
Released: 24 Nov 2021
Model geometry
Fit model/data
7vuq
7vuq
7vuq
Structure of NF-kB p52 homodimer bound to +1/-1 swap P-Selectin kB DNA fragment
Meshcheryakov VA, Wang VY-F
Elife (2023) [PMID: 36779700  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p52/p52 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-122242 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
3.4Å resolution
Released: 24 Nov 2021
Model geometry
Fit model/data
7vup
7vup
7vup
Structure of NF-kB p52 homodimer bound to 13-mer A/T-centric P-Selectin kB DNA fragment
Meshcheryakov VA, Wang VY-F
Elife (2023) [PMID: 36779700  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p52/p52 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-122257 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
3Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
7w7l
7w7l
7w7l
Structure of NF-kB p52 homodimer bound to P-Selectin kB DNA fragment
Meshcheryakov VA, Wang VY-F
Elife (2023) [PMID: 36779700  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p52/p52 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275800 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
3Å resolution
Released: 21 Jul 2021
Model geometry
Fit model/data
7cli
7cli
7cli
bipartite p52 NLS in complex with Importin alpha 2
Tsimbslyuk S, Stewart M, Forwood JK
To be published
Assembly composition: protein/protein complex
Assembly name: Nuclear factor NF-kappa-B p52 subunit and Importin subunit alpha-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273855 (Preferred)   search this ID
PDBe-KB: Q00653    P52293   
X-ray diffraction
2.1Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
8g8s
8g8s
8g8s
crystal structure of the C-terminal domain of p100/NF-kB2
Tao ZH, Huang DB, Fusco A, Gupta K, Ware CF, Duynne GV
Proc Natl Acad Sci U S A (2014) [PMID: 25349408  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: NF-kappaB transcription regulation complex, p52/p52 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-169463 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
3.35Å resolution
Released: 14 Jan 2015
Model geometry
Fit model/data
4ot9
4ot9
4ot9
Crystal structure of the dimerization domains p52 and RelB
Vu D, Huang DB, Ghosh G
J Mol Biol (2013) [PMID: 23485337  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Nuclear factor NF-kappa-B p52 subunit and Transcription factor RelB (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170084 (Preferred)   search this ID
PDBe-KB: Q9WTK5    Q04863   
X-ray diffraction
2.78Å resolution
Released: 24 Nov 2010
Model geometry
Fit model/data
3jv6
3jv6
3jv6
HUMAN NF-KAPPA-B P52 BOUND TO DNA
Cramer P, Larson CJ, Verdine GL, Muller CW
EMBO J (1997) [PMID: 9384586  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p52/p52 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-113392 (Preferred)   search this ID
PDBe-KB: Q00653   
X-ray diffraction
2.1Å resolution
Released: 11 Jun 1998
Model geometry
Fit model/data
Data not deposited
1a3q
1a3q
1a3q
Entries 1 to 10 of 13
Entries 1 to 10 of 13