Uniprot accession / id : Q9WTV6  OR   Uniprot accession / id : Q9UMW8
 
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Entry Information
Entry status  (1)
REL
(2)
 
Experimental methods  (1)
X-ray diffraction
(2)
 
Authors  (12)
Basters A
(2)
Fritz G
(2)
Geurink PP
(2)
Hess S
(2)
Knobeloch KP
(2)
Ovaa H
(2)
Rocker A
(2)
Röcker A
(2)
Semrau MS
(2)
Storici P
(2)
Tadayon R
(2)
Witting KF
(2)
 
Homo / hetero assembly  (2)
hetero
(1)
homo
(1)
 
Assembly composition  (2)
protein structure
(1)
protein/protein complex
(1)
 
Assembly polymer count  (2)
dimer
(1)
monomer
(1)
 
Resolution distribution
2.5 - 3
(1)
3.0 - 3.5
(1)
 
Release year distribution
2015 - 2020
(2)
 
Journal  (1)
Nat Struct Mol Biol
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(2)
 
Organism name  (1)
Mus musculus
(2)
 
Molecule name  (4)
43 kDa ISG15-specific protease
(2)
ISG15-specific-processing protease
(2)
Ubl carboxyl-terminal hydrolase 18
(2)
Ubl thioesterase 18
(2)
 
Molecule type  (1)
Protein
(2)
 
Gene names  (2)
Ubp43
(2)
Usp18
(2)
 
Interacting Molecules  (1)
Ubiquitin-like protein ISG15
(1)
 
Interacting ligands  (3)
ZN : ZINC ION
(2)
CL : CHLORIDE ION
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
EC number / name  (1)
3.4.19.12 : Ubiquitinyl hydrolase 1
(2)
 
Biological function  (1)
cysteine-type deubiquitinase activity
(2)
 
Biological process  (1)
protein deubiquitination
(2)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (1)
Cathepsin B; Chain A
(2)
 
Pfam accession / name  (1)
PF00443 : UCH
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (1)
SLS BEAMLINE X06SA
(2)
 
Synchrotron site  (1)
SLS
(2)
 
Diffraction detector type  (2)
CCD
(1)
Pixel
(1)
 
Refinement software  (1)
PHENIX
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 2 of 2
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Crystal structure of USP18
Fritz G, Basters A
Nat Struct Mol Biol (2017) [PMID: 28165509  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Ubl carboxyl-terminal hydrolase 18 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-194384 (Preferred)   search this ID
PDBe-KB: Q9WTV6   
X-ray diffraction
2.8Å resolution
Released: 29 Jun 2016
Model geometry
Fit model/data
5cht
5cht
5cht
Crystal structure of USP18-ISG15 complex
Fritz G, Basters A
Nat Struct Mol Biol (2017) [PMID: 28165509  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: ZN    SO4    ZN    CL   
Modified residues: AYE   
Assembly name: Ubl carboxyl-terminal hydrolase 18 and Ubiquitin-like protein ISG15 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-179124 (Preferred)   search this ID
PDBe-KB: Q9WTV6    Q64339   
X-ray diffraction
3.005Å resolution
Released: 28 Sep 2016
Model geometry
Fit model/data
5chv
5chv
5chv
Entries 1 to 2 of 2
Entries 1 to 2 of 2