Uniprot accession / id : Q9WU62  OR   Uniprot accession / id : Q9NQS7
 
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (2)
X-ray diffraction
(10)
Electron Microscopy
(1)
 
Authors  (40)
Barr FA
(4)
Serena M
(4)
Bastos RN
(3)
Bountra C
(3)
Elkins JM
(3)
Elliott PR
(3)
Knapp S
(3)
von Delft F
(3)
Abdul Azeez KR
(2)
Alpizar A
(2)
Arrowsmith C
(2)
Edwards AM
(2)
Marcilla M
(2)
Santiago C
(2)
Sorrell FJ
(2)
Arrowsmith CH
(1)
Chung CW
(1)
Conti E
(1)
Ebert J
(1)
Edwards A
(1)
Egner U
(1)
Gold DB
(1)
Gruneberg U
(1)
Hillig RC
(1)
Hilpmann A
(1)
Holton SJ
(1)
Jeyaprakash AA
(1)
Klein UR
(1)
Lindner D
(1)
Musacchio A
(1)
Nigg EA
(1)
Picaud S
(1)
Putter V
(1)
Pütter V
(1)
Roberts E
(1)
Ruza RR
(1)
Santaguida S
(1)
Schaefer M
(1)
Vollmar M
(1)
Wang J
(1)
 
Homo / hetero assembly  (1)
hetero
(11)
 
Assembly composition  (2)
protein/protein complex
(10)
DNA/protein complex
(1)
 
Assembly polymer count  (4)
dimer
(4)
trimer
(4)
tetramer
(2)
tridecamer
(1)
 
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(3)
2.0 - 2.5
(2)
2.5 - 3
(3)
3.0 - 3.5
(1)
 
Release year distribution
2005 - 2010
(1)
2010 - 2015
(1)
2015 - 2020
(7)
2020 - 2025
(5)
2025 - 2030
(1)
 
Journal  (6)
To be published
(4)
J Cell Biol
(3)
Acta Crystallogr D Struct Biol
(1)
Biorxiv
(1)
Cell
(1)
J Med Chem
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(11)
 
Organism name  (1)
Homo sapiens
(11)
 
Molecule name  (1)
Inner centromere protein
(11)
 
Molecule type  (1)
Protein
(11)
 
Gene names  (1)
INCENP
(11)
 
Interacting Molecules  (13)
Baculoviral IAP repeat-containing protein 5
(5)
Borealin
(5)
Aurora kinase C
(3)
Beta-2-microglobulin
(2)
HLA class I histocompatibility antigen, B alpha chain
(2)
Histone H3.1
(2)
Aurora kinase B
(1)
DNA (147-MER)
(1)
Histone H2A type 1
(1)
Histone H2B 1.1
(1)
Histone H3
(1)
Histone H3.2
(1)
Histone H4
(1)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(2)
 
CATH topology  (1)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(2)
 
Pfam accession / name  (2)
PF12178 : INCENP_N
(5)
PF03941 : INCENP_ARK-bind
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(10)
 
Diffraction radiation source type  (2)
Synchrotron
(9)
Rotating anode
(1)
 
Diffraction source  (8)
ALBA BEAMLINE XALOC
(2)
DIAMOND BEAMLINE I04
(2)
DIAMOND BEAMLINE I03
(1)
DIAMOND BEAMLINE I24
(1)
ESRF BEAMLINE ID23-1
(1)
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
(1)
RIGAKU MICROMAX-007 HF
(1)
SLS BEAMLINE X06SA
(1)
 
Synchrotron site  (5)
Diamond
(4)
ALBA
(2)
ESRF
(1)
PETRA III, EMBL c/o DESY
(1)
SLS
(1)
 
Diffraction detector type  (3)
Pixel
(6)
CCD
(3)
Image plate
(1)
 
Refinement software  (2)
PHENIX
(5)
REFMAC
(5)
 
EM microscope model  (1)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 11
Entries 1 to 10 of 11
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Structure of HLA-B*40:02 in complex with the endogenous peptide REFSKEPEL
Alpizar A, Marcilla M, Santiago C
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-135260 (Preferred)   search this ID
PDBe-KB: Q9NQS7    P61769    P01889   
X-ray diffraction
1.8Å resolution
Released: 7 Dec 2016
Model geometry
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5iek
5iek
5iek
Structure of HLA-B*40:02 in complex with the phosphorylated endogenous peptide REF(p)SKEPEL
Alpizar A, Marcilla M, Santiago C
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: EDO   
Modified residues: SEP    SEP   
PDBe complex ID: PDB-CPX-135260 (Preferred)   search this ID
PDBe-KB: Q9NQS7    P61769    P01889   
X-ray diffraction
1.5Å resolution
Released: 7 Dec 2016
Model geometry
Fit model/data
5ieh
5ieh
5ieh
Aurora-C with SER mutation in complex with INCENP peptide
Hillig RC
Acta Crystallogr D Struct Biol (2024) [PMID: 39207897  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: EDO   
Assembly name: Aurora kinase C and Inner centromere protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192512 (Preferred)   search this ID
PDBe-KB: Q9NQS7    Q9UQB9   
X-ray diffraction
2.8Å resolution
Released: 11 Sep 2024
Model geometry
Fit model/data
9esa
9esa
9esa
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A.
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    SO4    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-127457 (Preferred)   search this ID
PDBe-KB: Q9NQS7    O15392    Q53HL2    P68431   
X-ray diffraction
2.55Å resolution
Released: 13 May 2020
Model geometry
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6yih
6yih
6yih
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 1.8 A.
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    SO4    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-127457 (Preferred)   search this ID
PDBe-KB: Q9NQS7    O15392    Q53HL2    P68431   
X-ray diffraction
1.81Å resolution
Released: 13 May 2020
Model geometry
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6yif
6yif
6yif
Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
Ruza RR, Barr FA
Biorxiv (2025)
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-284729 (Preferred)   search this ID
PDBe-KB: Q9NQS7    O15392    P02281    A0A310TTQ1    P84233    Q53HL2    (view 2 more)
Electron Microscopy
2.42Å resolution
Released: 5 Feb 2025
Model geometry
Fit model/data
Data not analysed
8rup
8rup
8rup
Structure of a Borealin-INCENP-Survivin complex
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-127459 (Preferred)   search this ID
PDBe-KB: Q9NQS7    O15392    Q53HL2   
X-ray diffraction
3.49Å resolution
Released: 13 May 2020
Model geometry
Fit model/data
6yie
6yie
6yie
Human AURKC INCENP complex bound to BRD-7880
Abdul Azeez KR, Sorrell FJ, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: F8Z   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Aurora kinase C and Inner centromere protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192512 (Preferred)   search this ID
PDBe-KB: Q9NQS7    Q9UQB9   
X-ray diffraction
1.75Å resolution
Released: 15 May 2019
Model geometry
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6gr8
6gr8
6gr8
Crystal structure of a Survivin-Borealin-INCENP core complex
Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E
Cell (2007) [PMID: 17956729  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MES    ZN    ZN   
PDBe complex ID: PDB-CPX-127459 (Preferred)   search this ID
PDBe-KB: Q9NQS7    O15392    Q53HL2   
X-ray diffraction
1.4Å resolution
Released: 6 Nov 2007
Model geometry
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2qfa
2qfa
2qfa
Human AURKC INCENP complex bound to VX-680
Abdul Azeez KR, Sorrell FJ, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: VX6    SO4    VX6   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Aurora kinase C and Inner centromere protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-192512 (Preferred)   search this ID
PDBe-KB: Q9NQS7    Q9UQB9   
X-ray diffraction
2.25Å resolution
Released: 15 May 2019
Model geometry
Fit model/data
6gr9
6gr9
6gr9
Entries 1 to 10 of 11
Entries 1 to 10 of 11