Uniprot accession / id : (Q9Y337)
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
X-ray diffraction
(4)
 
Authors  (53)
Bode W
(2)
Debela M
(2)
Goettig P
(2)
Huber R
(2)
Magdolen V
(2)
Schechter NM
(2)
Arron JR
(1)
Austin CD
(1)
Balazs M
(1)
Cai H
(1)
Chavarria-Smith J
(1)
Chen E
(1)
Chiu CPC
(1)
Dunlap D
(1)
Edgar EV
(1)
Ghodge SV
(1)
Hackney JA
(1)
Hernandez-Barry H
(1)
Holmes DS
(1)
Hovnanian A
(1)
Jackman JK
(1)
Koerber JT
(1)
Lazarus RA
(1)
Lee WP
(1)
Lewell XQ
(1)
Li H
(1)
Li J
(1)
Liddle J
(1)
Lin WY
(1)
Liu J
(1)
Loyet KM
(1)
Maun HR
(1)
Morton WD
(1)
Nassau P
(1)
Pappu R
(1)
Pearce AC
(1)
Polyakova O
(1)
Rella M
(1)
Smith KJ
(1)
Sudhamsu J
(1)
Sun Y
(1)
Tam C
(1)
Tao J
(1)
Thorpe JH
(1)
Tyagi T
(1)
Walker AL
(1)
Wang Y
(1)
White GV
(1)
Wittwer AJ
(1)
Yaspan BL
(1)
Yi T
(1)
Yin J
(1)
Zhang J
(1)
 
Homo / hetero assembly  (2)
hetero
(3)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(3)
protein structure
(1)
 
Assembly polymer count  (3)
dimer
(2)
monomer
(1)
trimer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(3)
 
Release year distribution
2005 - 2010
(2)
2015 - 2020
(1)
2020 - 2025
(1)
 
Journal  (3)
J Mol Biol
(2)
Acta Crystallogr F Struct Biol Commun
(1)
Sci Transl Med
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (4)
KLK-L2
(4)
Kallikrein-5
(4)
Kallikrein-like protein 2
(4)
Stratum corneum tryptic enzyme
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (3)
KLK5
(4)
SCTE
(4)
UNQ570/PRO1132
(4)
 
Interacting Molecules  (3)
LEUPEPTIN
(2)
anti-KLK5 Fab Heavy Chain
(1)
anti-KLK5 Fab Light Chain
(1)
 
Interacting ligands  (5)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(3)
J08 : 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide
(1)
NA : SODIUM ION
(1)
SO4 : SULFATE ION
(1)
ZN : ZINC ION
(1)
 
Function and Biology
Biological function  (1)
serine-type endopeptidase activity
(4)
 
Biological process  (1)
proteolysis
(4)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(3)
 
CATH topology  (1)
Thrombin, subunit H
(3)
 
Pfam accession / name  (1)
PF00089 : Trypsin
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
MPG/DESY, HAMBURG BEAMLINE BW6
(2)
ALS BEAMLINE 5.0.1
(1)
DIAMOND BEAMLINE I04
(1)
 
Synchrotron site  (3)
MPG/DESY, HAMBURG
(2)
ALS
(1)
Diamond
(1)
 
Diffraction detector type  (2)
CCD
(2)
Pixel
(2)
 
Refinement software  (3)
CNS
(2)
BUSTER
(1)
PHENIX
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Crystal Structure of Human Kallikrein 5 in complex with Leupeptin
Debela M, Bode W, Goettig P
J Mol Biol (2007) [PMID: 17881000  ]
Assembly composition: protein/protein complex
Modified residues: ACE    ACE    AR7    AR7   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Kallikrein-5 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163179 (Preferred)   search this ID
PDBe-KB: Q9Y337   
X-ray diffraction
2.3Å resolution
Released: 11 Sep 2007
Model geometry
Fit model/data
2psx
2psx
2psx
Crystal Structure of Human Kallikrein 5 in complex with GSK144
Thorpe JH
Acta Crystallogr F Struct Biol Commun (2019) [PMID: 31045568  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAG    NA    J08    NAG    NA   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Kallikrein-5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195179 (Preferred)   search this ID
PDBe-KB: Q9Y337   
X-ray diffraction
1.67Å resolution
Released: 8 May 2019
Model geometry
Fit model/data
6qfe
6qfe
6qfe
Crystal Structure of Human Kallikrein 5 in complex with Leupeptin and Zinc
Debela M, Bode W, Goettig P
J Mol Biol (2007) [PMID: 17881000  ]
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Modified residues: ACE    ACE    AR7    AR7   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Kallikrein-5 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163180 (Preferred)   search this ID
PDBe-KB: Q9Y337   
X-ray diffraction
2.3Å resolution
Released: 11 Sep 2007
Model geometry
Fit model/data
2psy
2psy
2psy
Structure of Human KLK5 bound to anti-KLK5 Fab
Yin J, Sudhamsu J
Sci Transl Med (2022) [PMID: 36516271  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Kallikrein-5 and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-280355 (Preferred)   search this ID
PDBe-KB: Q9Y337   
X-ray diffraction
2.371Å resolution
Released: 14 Dec 2022
Model geometry
Fit model/data
7u5b
7u5b
7u5b
Entries 1 to 4 of 4
Entries 1 to 4 of 4