Uniprot accession / id : Q9Z0H3  OR   Uniprot accession / id : Q12824  OR   Uniprot accession / id : A0A0G2JSE9
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (3)
Solution NMR
(5)
Electron Microscopy
(4)
X-ray diffraction
(4)
 
Authors  (99)
Allen MD
(3)
Bycroft M
(3)
He S
(3)
Liu B
(3)
Xu Y
(3)
Yu J
(3)
Yu Z
(3)
Zinzalla G
(3)
Chen Z
(2)
Hamdani N
(2)
Han J
(2)
Joo K
(2)
Kim I
(2)
Kim T
(2)
Ko YJ
(2)
Lee J
(2)
Lee W
(2)
Li J
(2)
Mizutani K
(2)
Park GY
(2)
Park JH
(2)
Park SY
(2)
Ryu KS
(2)
Sammak S
(2)
Seong RH
(2)
Suh JY
(2)
Tian Y
(2)
Wang X
(2)
Wu Z
(2)
Yun JH
(2)
Acharya SA
(1)
Adams LJ
(1)
Almo SC
(1)
Barrett L
(1)
Bernowitz M
(1)
Bhutoria S
(1)
Bolonduro O
(1)
Brenowitz M
(1)
Cahill S
(1)
Cahill SM
(1)
Chen G
(1)
Chen K
(1)
Chen KJ
(1)
Chen ZC
(1)
Cheng YC
(1)
Collings CK
(1)
Comstock DE
(1)
Cowburn D
(1)
Dao HT
(1)
Dhe-Paganon S
(1)
Dixit U
(1)
Dornon MK
(1)
Du Y
(1)
Freund SM
(1)
Freund SMV
(1)
Giancotti FG
(1)
Girvin M
(1)
Girvin ME
(1)
Harris R
(1)
Hermawan C
(1)
Huang J
(1)
Kadoch C
(1)
Kalpana GV
(1)
Li W
(1)
Long J
(1)
Mashtalir N
(1)
Mathew S
(1)
Muir TW
(1)
Nguyen M
(1)
Pathak R
(1)
Prakash R
(1)
Qian C
(1)
Qiu L
(1)
Rajesh Kumar P
(1)
Ren Y
(1)
Seo HS
(1)
Spira M
(1)
St Pierre R
(1)
Steven AC
(1)
Sun ZY
(1)
Sun ZYJ
(1)
Valencia AM
(1)
Vangos HS
(1)
Vangos NE
(1)
Wang L
(1)
Wang Q
(1)
Wang Y
(1)
Woolf CJ
(1)
Wu X
(1)
Xie S
(1)
Yan L
(1)
Yeoh ZC
(1)
Yuan J
(1)
Yuan JJ
(1)
Zhang W
(1)
Zhang WB
(1)
Zhao J
(1)
Zhou H
(1)
Zou X
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(6)
 
Assembly composition  (3)
protein structure
(6)
protein/protein complex
(4)
DNA/protein complex
(3)
 
Assembly polymer count  (8)
monomer
(6)
24-mer
(1)
27-mer
(1)
dimer
(1)
icosamer
(1)
octamer
(1)
tetramer
(1)
trimer
(1)
 
Resolution distribution
2.0 - 2.5
(3)
2.5 - 3
(2)
3.0 - 3.5
(1)
3.5 - 4
(1)
4.0 - 4.5
(1)
 
Release year distribution
2010 - 2015
(1)
2015 - 2020
(11)
2020 - 2025
(7)
 
Journal  (9)
FEBS J
(2)
Int J Mol Sci
(2)
Nat Commun
(2)
Science
(2)
Cell
(1)
Cell Discov
(1)
J Mol Biol
(1)
Nature
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (1)
Homo sapiens
(13)
 
Molecule name  (6)
BAF47
(13)
BRG1-associated factor 47
(13)
Integrase interactor 1 protein
(13)
SNF5 homolog
(13)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
(13)
hSNF5
(13)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (4)
BAF47
(13)
INI1
(13)
SMARCB1
(13)
SNF5L1
(13)
 
Interacting Molecules  (27)
SWI/SNF complex subunit SMARCC2
(5)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
(4)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
(4)
Transcription activator BRG1
(4)
Actin, cytoplasmic 1
(3)
Actin-like protein 6A
(3)
Histone H4
(3)
AT-rich interactive domain-containing protein 1A
(2)
AT-rich interactive domain-containing protein 2
(2)
Bromodomain-containing protein 7
(2)
Histone H2A type 1
(2)
Histone H2B 1.1
(2)
PHD finger protein 10
(2)
Protein polybromo-1
(2)
SWI/SNF complex subunit SMARCC1
(2)
Zinc finger protein ubi-d4
(2)
DNA (119-MER)
(1)
DNA (207-MER)
(1)
DNA (213-MER)
(1)
Histone H2A type 1-C
(1)
Histone H2B type 1-C/E/F/G/I
(1)
Histone H3.1
(1)
Histone H3.2
(1)
Histone H3.3
(1)
Unknown
(1)
Unkown
(1)
unknown
(1)
 
Function and Biology
Biological function  (8)
DNA binding
(3)
RNA polymerase I core promoter sequence-specific DNA binding
(3)
Tat protein binding
(3)
identical protein binding
(3)
nucleosomal DNA binding
(3)
p53 binding
(3)
protein binding
(3)
transcription coactivator activity
(3)
 
Biological process  (26)
chromatin remodeling
(11)
DNA integration
(3)
RNA polymerase I preinitiation complex assembly
(3)
blastocyst development
(3)
blastocyst hatching
(3)
chromatin organization
(3)
hepatocyte differentiation
(3)
negative regulation of cell population proliferation
(3)
nervous system development
(3)
nucleosome disassembly
(3)
positive regulation by host of viral transcription
(3)
positive regulation of T cell differentiation
(3)
positive regulation of cell differentiation
(3)
positive regulation of double-strand break repair
(3)
positive regulation of glucose mediated signaling pathway
(3)
positive regulation of myoblast differentiation
(3)
positive regulation of stem cell population maintenance
(3)
positive regulation of transcription by RNA polymerase II
(3)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
(3)
regulation of G0 to G1 transition
(3)
regulation of G1/S transition of mitotic cell cycle
(3)
regulation of mitotic metaphase/anaphase transition
(3)
regulation of nucleotide-excision repair
(3)
regulation of transcription by RNA polymerase II
(3)
single stranded viral RNA replication via double stranded DNA intermediate
(3)
transcription initiation-coupled chromatin remodeling
(3)
 
Biological cell component  (18)
nuclear chromosome
(11)
RSC-type complex
(3)
SWI/SNF complex
(3)
XY body
(3)
bBAF complex
(3)
brahma complex
(3)
chromatin
(3)
fibrillar center
(3)
germ cell nucleus
(3)
intracellular membrane-bounded organelle
(3)
kinetochore
(3)
nBAF complex
(3)
npBAF complex
(3)
nuclear matrix
(3)
nucleolus
(3)
nucleoplasm
(3)
nucleus
(3)
protein-containing complex
(3)
 
Sequence and Structure classification
Pfam accession / name  (2)
PF04855 : SNF5
(11)
PF21459 : INI1_DNA-bd
(5)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (2)
Synchrotron
(3)
Rotating anode
(1)
 
Diffraction source  (4)
PAL/PLS BEAMLINE 5C (4A)
(1)
RIGAKU FR-E+ SUPERBRIGHT
(1)
SSRF BEAMLINE BL17U
(1)
SSRF BEAMLINE BL19U1
(1)
 
Synchrotron site  (2)
SSRF
(2)
PAL/PLS
(1)
 
Diffraction detector type  (3)
CCD
(2)
Image plate
(1)
Pixel
(1)
 
Refinement software  (1)
PHENIX
(5)
 
EM microscope model  (1)
FEI TITAN KRIOS
(4)
 
EM detector name  (2)
GATAN K2 SUMMIT (4k x 4k)
(2)
GATAN K3 (6k x 4k)
(2)
 
NMR
NMR software packages  (14)
CNS
(3)
Xplor-NIH
(3)
ANSIG
(2)
NMRPipe
(2)
ARIA
(1)
CARA
(1)
CYANA
(1)
CcpNmr Analysis
(1)
NMRDraw
(1)
Sparky
(1)
TALOS
(1)
TopSpin
(1)
VNMR
(1)
hmsIST
(1)
 
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(4)
600.0 - 700
(4)
700.0 - 800
(3)
800.0 - 900
(3)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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90%
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
 Select all entries on this page
Crystal Structure of BAF47 and BAF155 Complex
Yan L, Qian C
J Mol Biol (2017) [PMID: 28438634  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    PO4   
Assembly name: SWI/SNF complex subunit SMARCC1 and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171404 (Preferred)   search this ID
PDBe-KB: Q12824    Q92922   
X-ray diffraction
2.052Å resolution
Released: 7 Jun 2017
Model geometry
Fit model/data
5gjk
5gjk
5gjk
RPT1 region of INI1/SNF5/SMARCB1_HUMAN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
Girvin ME, Cahill SM, Harris R, Cowburn D, Spira M, Wu X, Prakash R, Bernowitz M, Almo SC, Kalpana GV
Nat Commun (2021) [PMID: 33980829  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171401 (Preferred)   search this ID
PDBe-KB: Q12824   
Solution NMR
Released: 18 Oct 2017
Model geometry
Fit model/data
Data not analysed
6ax5
6ax5
6ax5
Solution structure of the human SNF5/INI1 domain
Allen MD, Zinzalla G, Bycroft M
FEBS J (2018) [PMID: 30222246  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171401 (Preferred)   search this ID
PDBe-KB: Q12824   
Solution NMR
Released: 10 May 2017
Model geometry
Fit model/data
Data not analysed
5l7b
5l7b
5l7b
The solution structure of N-terminal elongated hSNF5 RPT1 domain
Lee W, Han J, Kim I, Suh JY
Int J Mol Sci (2020) [PMID: 32244797  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171401 (Preferred)   search this ID
PDBe-KB: Q12824   
Solution NMR
Released: 30 Dec 2020
Model geometry
Fit model/data
Data not analysed
6lzp
6lzp
6lzp
Crystal structure of the SMARCB1/SMARCC2 subcomplex
Chen G, Zhou H, Giancotti FG, Long J
Cell Discov (2020) [PMID: 33024572  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: SWI/SNF complex subunit SMARCC2 and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171402 (Preferred)   search this ID
PDBe-KB: Q12824    Q8TAQ2   
X-ray diffraction
2.601Å resolution
Released: 23 Sep 2020
Model geometry
Fit model/data
6kag
6kag
6kag
Structure of human BAF Base module
He S, Wu Z, Tian Y, Yu Z, Yu J, Wang X, Li J, Liu B, Xu Y
Science (2020) [PMID: 32001526  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-126984 (Preferred)   search this ID
PDBe-KB: Q12824    Q8TAQ2    O14497    P51532    Q96GM5    Q92785    (view 1 more)
Electron Microscopy
3Å resolution
Released: 12 Feb 2020
Model geometry
Fit model/data
Data not analysed
6lth
6lth
6lth
SMARCB1 nucleosome-interacting C-terminal alpha helix
Valencia AM, Sun ZYJ, Seo HS, Vangos HS, Yeoh ZC, Mashtalir N, Dhe-Paganon S, Kadoch C
Cell (2019) [PMID: 31759698  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171401 (Preferred)   search this ID
PDBe-KB: Q12824   
Solution NMR
Released: 27 Nov 2019
Model geometry
Fit model/data
Data not analysed
6uch
6uch
6uch
Structure of nucleosome-bound human BAF complex
He S, Wu Z, Tian Y, Yu Z, Yu J, Wang X, Li J, Liu B, Xu Y
Science (2020) [PMID: 32001526  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-120225 (Preferred)   search this ID
PDBe-KB: Q12824    P02281    Q8TAQ2    O14497    P51532    O96019    (view 7 more)
Electron Microscopy
3.7Å resolution
Released: 12 Feb 2020
Model geometry
Fit model/data
Data not analysed
6ltj
6ltj
6ltj
The crystal structure of BAF155 SWIRM domain and N-terminal elongated hSNF5 RPT1 domain complex: Chromatin remodeling complex
Lee W, Han J, Kim I, Park JH, Joo K, Lee J, Suh JY
Int J Mol Sci (2020) [PMID: 32244797  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: SWI/SNF complex subunit SMARCC1 and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171403 (Preferred)   search this ID
PDBe-KB: Q12824    Q92922   
X-ray diffraction
2.28Å resolution
Released: 8 Jul 2020
Model geometry
Fit model/data
6kz7
6kz7
6kz7
The crystal structure of the Human SNF5/INI1 domain
Allen MD, Zinzalla G, Bycroft M
FEBS J (2018) [PMID: 30222246  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171401 (Preferred)   search this ID
PDBe-KB: Q12824   
X-ray diffraction
2.102Å resolution
Released: 10 May 2017
Model geometry
Fit model/data
5l7a
5l7a
5l7a
Entries 1 to 10 of 13
Entries 1 to 10 of 13