Entries released this week  (1)

revised

(1)

Entry status  (1)

REL

(30)

Experimental methods  (1)

X-ray diffraction

(30)

Authors  (170)

Arrowsmith CH

(9)

Brown PJ

(8)

Hashimoto N

(8)

Ito A

(8)

Jin J

(8)

Nakata A

(8)

Namie R

(8)

Nishigaya Y

(8)

Niwa H

(8)

Sato S

(8)

Shirai F

(8)

Shirouzu M

(8)

Sumiya T

(8)

Takase S

(8)

Umehara T

(8)

Vedadi M

(8)

Yoshida M

(8)

Dong A

(7)

Honma T

(7)

Koyama H

(7)

Sato T

(7)

Babault N

(6)

Chen X

(6)

Edwards AM

(6)

Liu J

(6)

Structural Genomics Consortium (SGC)

(6)

Wu H

(6)

Xiong Y

(6)

Zeng H

(6)

Bountra C

(5)

Li F

(5)

Sonoda T

(5)

Allis CD

(4)

Bellon S

(4)

Bellon SF

(4)

Bochkarev A

(4)

Cantone N

(4)

Cummings R

(4)

Hoelper D

(4)

Jain SU

(4)

Jayaram H

(4)

Kikuzato K

(4)

Lewis PW

(4)

Lundgren SM

(4)

Maemoto Y

(4)

Matsuoka S

(4)

Poy F

(4)

Weigelt J

(4)

Allali-Hassani A

(3)

Hiramoto K

(3)

Ihara K

(3)

Ishii K

(3)

Ishiyama T

(3)

Katagiri T

(3)

Katayama K

(3)

Suzuki M

(3)

Torihata M

(3)

Tsuda E

(3)

Yasumatsu I

(3)

Yotsumoto K

(3)

Andrews S

(2)

Barsyte D

(2)

Chau I

(2)

Chen H

(2)

Frye SV

(2)

Herold JM

(2)

Igarashi W

(2)

Jia S

(2)

Kireev DB

(2)

Kozieradzki I

(2)

Liu F

(2)

Loppnau P

(2)

Min J

(2)

Moresco JJ

(2)

Nagy PL

(2)

Senisterra G

(2)

Shan CM

(2)

Siarheyeva A

(2)

Tong L

(2)

Wang J

(2)

Wasney GA

(2)

Xu K

(2)

Yates JR

(2)

Yue JX

(2)

Amaya MF

(1)

Antoshenko T

(1)

Arata M

(1)

Arora K

(1)

BABAULT N

(1)

BROWN PJ

(1)

Barsyte-Lovejoy D

(1)

Briknarova K

(1)

Briknarová K

(1)

Campagna-Slater V

(1)

Chavda N

(1)

Chiang GG

(1)

Cocozaki A

(1)

DONG A

(1)

Dimaggio PA

(1)

Dombrovski L

(1)

 

More...

Homo / hetero assembly  (2)

homo

(23)

hetero

(7)

Assembly composition  (2)

protein structure

(23)

protein/protein complex

(7)

Assembly polymer count  (3)

dimer

(21)

monomer

(5)

tetramer

(4)

Resolution distribution

1.0 - 1.5

(4)

1.5 - 2

(20)

2.0 - 2.5

(3)

2.5 - 3

(3)

Release year distribution

2005 - 2010

(3)

2010 - 2015

(2)

2015 - 2020

(14)

2020 - 2025

(13)

2025 - 2030

(3)

Journal  (11)

J Med Chem

(8)

Bioorg Med Chem Lett

(5)

Proc Natl Acad Sci U S A

(4)

ACS Med Chem Lett

(2)

Bioorg Med Chem

(2)

Elife

(2)

PLoS One

(2)

To be published

(2)

J Struct Biol X

(1)

Nat Chem Biol

(1)

Nat Commun

(1)

Organism superkingdom  (1)

Eukaryota

(30)

Organism name  (1)

Homo sapiens

(30)

Molecule name  (7)

Euchromatic histone-lysine N-methyltransferase 2

(30)

H3-K9-HMTase 3

(30)

HLA-B-associated transcript 8

(30)

Histone H3-K9 methyltransferase 3

(30)

Histone-lysine N-methyltransferase EHMT2

(30)

Lysine N-methyltransferase 1C

(30)

Protein G9a

(30)

Molecule type  (1)

Protein

(30)

Gene names  (6)

BAT8

(30)

C6orf30

(30)

EHMT2

(30)

G9A

(30)

KMT1C

(30)

NG36

(30)

Interacting Molecules  (2)

Histone H3.1

(6)

Chromobox protein homolog 3

(1)

Interacting ligands  (30)

ZN : ZINC ION

(29)

SAM : S-ADENOSYLMETHIONINE

(16)

SFG : SINEFUNGIN

(8)

EDO : 1,2-ETHANEDIOL

(5)

SAH : S-ADENOSYL-L-HOMOCYSTEINE

(5)

CL : CHLORIDE ION

(4)

TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(4)

2OD : 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine

(1)

7KZ : N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine

(1)

7L6 : 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine

(1)

90P : N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine

(1)

9HG : N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine

(1)

9HJ : 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine

(1)

A1AEB : (2R)-1-(azetidin-1-yl)-3-(2-methoxy-5-{[4-methyl-6-(methylamino)pyrimidin-2-yl]amino}phenoxy)propan-2-ol

(1)

A1L07 : 3,6,6-trimethyl-~{N}-[(2~{S})-1-[[4-(1-methylpiperidin-4-yl)oxyphenyl]amino]-1-oxidanylidene-hexan-2-yl]-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

A1L08 : 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-[(phenylmethyl)amino]hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

A1L09 : ~{N}-[(2~{S})-1-[[4-[(dimethylamino)methyl]phenyl]methylamino]-1-oxidanylidene-hexan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

CIQ : 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

(1)

DXQ : 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

(1)

F80 : N2-[4-methoxy-3-(2,3,4,7-tetrahydro-1H-azepin-5-yl)phenyl]-N4,6-dimethyl-pyrimidine-2,4-diamine

(1)

G4R : N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide

(1)

G5U : N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide

(1)

GOL : GLYCEROL

(1)

H30 : 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine

(1)

I5X : ~{N}-[(1~{S})-1-(1~{H}-benzimidazol-2-yl)-3-methylsulfanyl-propyl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

I6L : ~{N}-[(1~{S})-1-(1~{H}-benzimidazol-2-yl)pentyl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

I6S : 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-phenylazanyl-hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

I6Z : ~{N}-[(2~{S})-4-cyclopropyl-1-oxidanylidene-1-phenylazanyl-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide

(1)

J26 : N-[(2S)-1-[(4-cyanophenyl)amino]-4-cyclopropyl-1-oxidanylidene-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1H-indole-2-carboxamide

(1)

N47 : N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine

(1)

EC number / name  (1)

2.1.1.367 : [Histone H3]-lysine(9) N-methyltransferase

(30)

Biological function  (4)

histone methyltransferase activity

(25)

p53 binding

(25)

protein-lysine N-methyltransferase activity

(25)

zinc ion binding

(25)

Biological cell component  (1)

nucleus

(24)

CATH class  (1)

Mainly Beta

(15)

Representative Structures

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95%

90%

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