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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(6)
Electron Microscopy
(3)
Authors
(56)
Alfieri C
(2)
Bajaj R
(2)
Barford D
(2)
Blundell TL
(2)
Bolanos-Garcia VM
(2)
Bollen M
(2)
Page R
(2)
Peti W
(2)
Wang X
(2)
Brown NG
(1)
Chang L
(1)
Chirgadze DY
(1)
Cota E
(1)
D'Arcy S
(1)
Davies OR
(1)
Dube P
(1)
Haselbach D
(1)
Kops GJ
(1)
Lee SH
(1)
Li B
(1)
Li X
(1)
Lischetti T
(1)
Luo X
(1)
Maslen S
(1)
Matak-Vinkovic D
(1)
Matak-Vinković D
(1)
Nilsson J
(1)
Peters JM
(1)
Qiao R
(1)
Rao Z
(1)
Robinson CV
(1)
Schulman B
(1)
Schulman BA
(1)
Sidhu SS
(1)
Simpson PJ
(1)
Skehel M
(1)
Spring DR
(1)
Stark H
(1)
Tian W
(1)
Tischer T
(1)
Tomchick DR
(1)
VanderLinden R
(1)
Virshup DM
(1)
Wang J
(1)
Wang Z
(1)
Warrington R
(1)
Weissmann F
(1)
Xu W
(1)
Yamaguchi M
(1)
Yang H
(1)
Yang J
(1)
Yu H
(1)
Yu T
(1)
Zhang W
(1)
Zhang Z
(1)
Zhou W
(1)
Homo / hetero assembly
(2)
hetero
(8)
homo
(1)
Assembly composition
(2)
protein/protein complex
(8)
protein structure
(1)
Assembly polymer count
(3)
dimer
(5)
23-mer
(3)
monomer
(1)
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(3)
2.5 - 3
(2)
3.5 - 4
(1)
4.0 - 4.5
(1)
4.5 - 5
(1)
Release year distribution
2005 - 2010
(1)
2010 - 2015
(3)
2015 - 2020
(6)
2020 - 2025
(1)
Journal
(7)
Structure
(3)
EMBO Rep
(1)
J Biol Chem
(1)
Mol Cell
(1)
Nature
(1)
Proc Natl Acad Sci U S A
(1)
Protein Cell
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(9)
Organism name
(1)
Homo sapiens
(9)
Molecule name
(5)
MAD3/BUB1-related protein kinase
(9)
Mitotic checkpoint kinase MAD3L
(9)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(9)
Protein SSK1
(9)
hBUBR1
(9)
Molecule type
(1)
Protein
(9)
Gene names
(4)
BUB1B
(9)
BUBR1
(9)
MAD3L
(9)
SSK1
(9)
Interacting Molecules
(19)
Cell division cycle protein 20 homolog
(4)
Anaphase-promoting complex subunit 1
(3)
Anaphase-promoting complex subunit 10
(3)
Anaphase-promoting complex subunit 11
(3)
Anaphase-promoting complex subunit 13
(3)
Anaphase-promoting complex subunit 16
(3)
Anaphase-promoting complex subunit 2
(3)
Anaphase-promoting complex subunit 4
(3)
Anaphase-promoting complex subunit 5
(3)
Anaphase-promoting complex subunit 7
(3)
Anaphase-promoting complex subunit CDC26
(3)
Cell division cycle protein 16 homolog
(3)
Cell division cycle protein 23 homolog
(3)
Cell division cycle protein 27 homolog
(3)
Mitotic spindle assembly checkpoint protein MAD2A
(3)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
(3)
Anaphase-promoting complex subunit 15
(2)
Outer kinetochore KNL1 complex subunit KNL1
(1)
unknown
(1)
Interacting ligands
(3)
ACT : ACETATE ION
(1)
EDO : 1,2-ETHANEDIOL
(1)
PR : PRASEODYMIUM ION
(1)
Function and Biology
EC number / name
(1)
2.7.11.1 : Non-specific serine/threonine protein kinase
(9)
Biological function
(8)
ATP binding
(2)
kinase activity
(2)
nucleotide binding
(2)
protein binding
(2)
protein kinase activity
(2)
protein serine kinase activity
(2)
protein serine/threonine kinase activity
(2)
transferase activity
(2)
Biological process
(6)
mitotic spindle assembly checkpoint signaling
(5)
apoptotic process
(2)
cell division
(2)
meiotic sister chromatid cohesion, centromeric
(2)
metaphase/anaphase transition of mitotic cell cycle
(2)
protein localization to chromosome, centromeric region
(2)
Biological cell component
(14)
anaphase-promoting complex
(2)
centrosome
(2)
chromosome
(2)
chromosome, centromeric region
(2)
ciliary basal body
(2)
cytoplasm
(2)
cytoskeleton
(2)
cytosol
(2)
kinetochore
(2)
mitotic checkpoint complex
(2)
nucleus
(2)
outer kinetochore
(2)
perinuclear region of cytoplasm
(2)
spindle
(2)
Sequence and Structure classification
CATH class
(1)
Mainly Alpha
(2)
CATH topology
(1)
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
(2)
Pfam accession / name
(1)
PF08311 : Mad3_BUB1_I
(5)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(6)
Diffraction radiation source type
(2)
Synchrotron
(5)
Rotating anode
(1)
Diffraction source
(5)
SSRL BEAMLINE BL12-2
(2)
APS BEAMLINE 19-ID
(1)
BRUKER AXS MICROSTAR-H
(1)
DIAMOND BEAMLINE I03
(1)
SSRF BEAMLINE BL17U
(1)
Synchrotron site
(4)
SSRL
(2)
APS
(1)
Diamond
(1)
SSRF
(1)
Diffraction detector type
(2)
CCD
(4)
Pixel
(2)
Refinement software
(2)
PHENIX
(4)
REFMAC
(4)
EM microscope model
(2)
FEI POLARA 300
(2)
FEI TITAN KRIOS
(1)
EM detector name
(2)
FEI FALCON II (4k x 4k)
(2)
FEI FALCON III (4k x 4k)
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 9 of 9
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Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution
Yamaguchi M, VanderLinden R, Dube P, Stark H, Schulman B
Mol Cell
(2016)
[PMID: 27522463 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-130029 (Preferred)
search this ID
Crystal structure of a PP2A B56gamma/BubR1 complex
Wang Z, Wang J, Rao Z, Xu W
Protein Cell
(2016)
[PMID: 27350047 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform and Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130031 (Preferred)
search this ID
The structure of the PP2A B56 subunit double phosphorylated BubR1 complex
Page R, Wang X, Bajaj R, Peti W
Structure
(2016)
[PMID: 27998540 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform and Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130031 (Preferred)
search this ID
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 4.2 angstrom resolution
Alfieri C, Chang L, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature
(2016)
[PMID: 27509861 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-130028 (Preferred)
search this ID
The structure of the PP2A B56 subunit BubR1 complex
Page R, Wang X, Bajaj R, Peti W
Structure
(2016)
[PMID: 27998540 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform and Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130031 (Preferred)
search this ID
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution
Alfieri C, Barford D
EMBO Rep
(2020)
[PMID: 32307883 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-130028 (Preferred)
search this ID
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Luo X, Tian W, Tomchick DR
Proc Natl Acad Sci U S A
(2012)
[PMID: 23091007 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Cell division cycle protein 20 homolog and Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130030 (Preferred)
search this ID
Kinetochore-BUBR1 kinase complex
Blundell TL, Chirgadze DY, Bolanos-Garcia VM
Structure
(2011)
[PMID: 22000412 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Outer kinetochore KNL1 complex subunit KNL1 and Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130032 (Preferred)
search this ID
Crystal Structure of the N-terminal Domain of BubR1
D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM
J Biol Chem
(2010)
[PMID: 20220147 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130027 (Preferred)
search this ID

Entries 1 to 9 of 9