PDBsum entry 4p5e

Hydrolase

PDB id: 4p5e

Contents

Protein chains

140 a.a.

Ligands

N6P ×2

Metals

_CA

Waters ×387

PDB id:

4p5e

Name:

Hydrolase

Title:

Crystal structure of human dnph1 (rcl) with 6-naphthyl-purine- riboside-monophosphate

Structure:

2'-deoxynucleoside 5'-phosphate n-hydrolase 1. Chain: a, b. Synonym: c-myc-responsive protein rcl. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dnph1, c6orf108, rcl. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.35Å R-factor: 0.156 R-free: 0.180

Authors:

A.Padilla,G.Labesse,P.A.Kaminski

Key ref:

C.Amiable et al. (2014). 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities. Eur J Med Chem, 85, 418-437. PubMed id: 25108359 DOI: 10.1016/j.ejmech.2014.07.110

Date:

16-Mar-14 Release date: 20-Aug-14

Protein chains

O43598  (DNPH1_HUMAN) -  2'-deoxynucleoside 5'-phosphate N-hydrolase 1 from Homo sapiens

Seq: 174 a.a.

Struc: 140 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.2.2.- - ?????

DOI no: 10.1016/j.ejmech.2014.07.110

Eur J Med Chem 85:418-437 (2014)

PubMed id: 25108359

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.

C.Amiable, J.Paoletti, A.Haouz, A.Padilla, G.Labesse, P.A.Kaminski, S.Pochet.

ABSTRACT

No abstract given.