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PDBsum entry 5wdp
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Oncoprotein, hydrolase
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PDB id
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5wdp
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PDB id:
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| Name: |
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Oncoprotein, hydrolase
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Title:
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H-ras mutant l120a bound to gmp-pnp at 277k
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Structure:
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Gtpase hras. Chain: a. Synonym: h-ras-1, ha-ras, transforming protein p21, c-h-ras, p21ras. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hras, hras1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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1.35Å
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R-factor:
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0.146
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R-free:
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0.154
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Authors:
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J.C.Cofsky,P.Bandaru,C.L.Gee,J.Kuriyan
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Key ref:
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P.Bandaru
et al.
(2017).
Deconstruction of the ras switching cycle through sat mutagenesis..
Elife,
6,
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PubMed id:
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Date:
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05-Jul-17
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Release date:
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19-Jul-17
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PROCHECK
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Headers
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References
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P01112
(RASH_HUMAN) -
GTPase HRas from Homo sapiens
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Seq:
Struc:
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189 a.a.
166 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.6.5.2
- small monomeric GTPase.
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Reaction:
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GTP + H2O = GDP + phosphate + H+
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GTP
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+
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H2O
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=
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GDP
Bound ligand (Het Group name = )
matches with 81.82% similarity
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
