PDBsum entry 8qwz

Transferase

PDB id: 8qwz

Contents

Protein chains

330 a.a.

Ligands

SO4 ×11

X5E ×2

Waters ×44

PDB id:

8qwz

Name:

Transferase

Title:

Crystal structure of human casein kinase ii subunit alpha (ck2a1) in complex with 4-(6-(6-isopropoxy-1h-indol-1-yl)pyrazin-2-yl)benzoic acid

Structure:

Casein kinase ii subunit alpha. Chain: a, b. Synonym: ck ii alpha. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1, ck2a1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.60Å R-factor: 0.208 R-free: 0.245

Authors:

A.Kraemer,K.Galal,T.Willson,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

A.Kraemer et al. Crystal structure of human casein kinase ii subunit a (ck2a1) in complex with 4-(6-(6-Isopropoxy-1h-Indol-1-Yl)pyrazin-2-Yl)benzoic. To be published, .

Date:

20-Oct-23 Release date: 17-Jan-24

Protein chains

P68400  (CSK21_HUMAN) -  Casein kinase II subunit alpha from Homo sapiens

Seq: 391 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site