M-CSA Mechanism and Catalytic Site Atlas

2,4-dienoyl-CoA reductase (NADPH) (M-CSA:108)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences homologous to 1ps9

Reference PDB chains/ identical chains	Homologous PDB chains	His252A Arg214A Gln339A Glu164A Tyr166A
1ps9(A)	3k30(B,A)	not aligned Arg230 Ile353 His179 Tyr181
1ps9(A)	3gka(B,A)	not aligned His233 not aligned Asn184 Tyr186
1ps9(A)	5epd(A)	not aligned Arg248 not aligned Asn199 Tyr201
1ps9(A)	1gwj(A)	not aligned Arg238 not aligned Asn189 Cys191
1ps9(A)	4tmc(C,B,A,D) 4tmb(C,B,A,D)	not aligned Arg243 not aligned Asn194 Tyr196
1ps9(A)	1gvq(A) 1vyr(A) 3f03(K) 1h60(A) 1h62(A) 1gvr(A) 2aba(A) 1h50(A) 1gvo(A) 3kft(B,A) 1h63(A) 1h51(A) 1h61(A) 1gvs(A)	not aligned Arg233 not aligned His184 Tyr186
1ps9(A)	3p84(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	4awt(A) 4aws(A)	not aligned Arg233 not aligned Asn184 Tyr186
1ps9(A)	3hgs(B,A) 2hsa(B,A) 2hs6(B,A)	not aligned Arg243 not aligned His194 Tyr196
1ps9(A)	5dy2(A) 5dy3(A) 5dxy(A)	not aligned Arg232 not aligned His183 Tyr185
1ps9(A)	5dxx(A)	not aligned Arg232 not aligned His183 Tyr185
1ps9(A)	5cpo(B,A) 5cpn(B,A) 5cpm(B,A) 5cpl(B,A)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	4gxm(A) 4gwe(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	4ge8(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3wjs(A)	not aligned Arg224 not aligned Asn175 Tyr177
1ps9(A)	4ab4(B,A) 4aeo(B,A)	not aligned His225 not aligned Asn176 Tyr178
1ps9(A)	3n14(A)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	3hf3(C,B,A,D) 3hgj(C,B,A,D)	not aligned Arg225 not aligned His175 Tyr177
1ps9(A)	3txz(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3hgo(B,A)	not aligned Arg243 not aligned His194 Tyr196
1ps9(A)	3l5a(A)	not aligned Arg248 Asp375 Gln193 Leu195
1ps9(A)	2gou(A) 2gq9(A) 2gq8(A) 2gqa(A)	not aligned Arg233 not aligned Asn184 Tyr186
1ps9(A)	4rnv(C,B,A,D) 4rnu(C,B,A,D)	not aligned Arg342 not aligned Asn293 Tyr295
1ps9(A)	3l67(A) 3l68(A)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	4utm(A) 4uti(A) 4uth(A) 4utj(A) 4utk(A) 4utl(A)	not aligned Arg233 not aligned His183 Phe185
1ps9(A)	1icq(B,A) 3hgr(B,A) 1icp(B,A) 1ics(B,A)	not aligned Arg239 not aligned His190 Tyr192
1ps9(A)	3gr8(B,A) 3gr7(B,A)	not aligned Arg215 not aligned His167 Tyr169
1ps9(A)	4e2d(C,B,A,D) 4e2b(A)	not aligned Arg252 not aligned Asn201 Tyr203
1ps9(A)	4qai(E,C,F,D,A,B)	not aligned Arg240 not aligned His191 Tyr193
1ps9(A)	1o94(B,A) 1djn(B,A) 1o95(B,A) 2tmd(B,A)	not aligned Arg222 Val350 His172 Tyr174
1ps9(A)	4rnx(B,A)	not aligned Arg92 not aligned Asn43 Tyr45
1ps9(A)	5n6g(A)	not aligned Arg230 not aligned Asn181 Tyr183
1ps9(A)	4m5p(A)	not aligned Arg240 not aligned His191 Tyr193
1ps9(A)	1oyc(A) 3tx9(A) 1oya(A) 1oyb(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3atz(C,B,A,D) 3aty(B,A)	not aligned Arg249 not aligned Asn198 Tyr200
1ps9(A)	3l5m(A) 3l5l(A) 3n19(B,D)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	2g5w(B,A) 2q3o(B,A) 1q45(B,A)	not aligned Arg238 not aligned His189 Tyr191
1ps9(A)	1z42(B,A) 1z41(B,A) 1z48(B,A) 1z44(B,A)	not aligned Arg215 not aligned His167 Tyr169
1ps9(A)	5ocs(C,B,A,D)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	4ync(A) 4yil(A)	not aligned Arg243 not aligned Asn194 Tyr196
1ps9(A)	1k02(A) 1k03(A)	not aligned Arg243 not aligned Asn194 Tyr196
1ps9(A)	1bwl(A)	not aligned Arg243 not aligned His194 Tyr196
1ps9(A)	3p62(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	3l66(A) 3l65(A)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	4ot7(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3p8i(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	4rnw(B,A)	not aligned Arg338 not aligned Asn289 Tyr291
1ps9(A)	2r14(A)	not aligned Arg238 not aligned Asn189 Cys191
1ps9(A)	4qnw(A)	not aligned Lys225 not aligned Asn176 Tyr178
1ps9(A)	2hs8(B,A)	not aligned Arg243 not aligned His194 Tyr196
1ps9(A)	3p7y(A) 3p80(A) 3p81(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	5lnj(A)	not aligned Arg230 not aligned His180 Phe182
1ps9(A)	2h90(A) 2h8z(A)	not aligned Arg230 not aligned His180 Tyr182
1ps9(A)	4awu(A)	not aligned Arg233 not aligned Asn184 Tyr186
1ps9(A)	4gbu(A) 4k7v(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3p74(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	5lni(A)	not aligned Arg230 not aligned His180 Phe182
1ps9(A)	5v4p(B,A) 5v4v(B,A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	4a3u(B,A)	not aligned Arg224 not aligned Asn175 Tyr177
1ps9(A)	1vji(A) 2q3r(A)	not aligned Arg235 not aligned Asn186 Tyr188
1ps9(A)	1djq(B,A)	not aligned Arg222 Val350 His172 Tyr174
1ps9(A)	1bwk(A)	not aligned Arg243 not aligned Asn194 Tyr196
1ps9(A)	4df2(A)	not aligned Arg240 not aligned His191 Tyr193
1ps9(A)	3p82(A)	not aligned Arg234 not aligned Asn185 Tyr187
1ps9(A)	1vyp(X)	not aligned Arg233 not aligned His184 Tyr186
1ps9(A)	3p67(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	3p8j(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	2abb(A)	not aligned Arg233 not aligned His184 Phe186
1ps9(A)	5k1q(A) 5k1w(A) 5k1u(A) 4b5n(A) 5k1m(A) 5k0r(A) 5k1k(A)	Asp275 Arg234 not aligned Asn185 Tyr187
1ps9(A)	3krz(C,B,A,D)	not aligned Arg216 not aligned His166 Tyr168
1ps9(A)	5lgx(A) 5lgz(A)	not aligned Arg232 not aligned His183 Tyr185
1ps9(A)	3kru(C,B,A,D)	not aligned Arg216 not aligned His166 Tyr168
1ps9(A)	3tjl(A) 3upw(A)	not aligned Arg240 not aligned His191 Tyr193
1ps9(A)	4k7y(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	6gi7(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	1ps9(A)	x x x x x
1ps9(A)	2h8x(A)	not aligned Arg229 not aligned His179 Tyr181
1ps9(A)	4jic(C,B,A) 4jip(A) 4jiq(A)	not aligned Arg230 not aligned Asn181 Tyr183
1ps9(A)	5n6q(B,A)	not aligned Arg231 not aligned His181 Tyr183
1ps9(A)	4k8h(A) 4k8e(A) 4h4i(A)	not aligned Arg244 not aligned Asn195 Tyr197
1ps9(A)	3gx9(A)	not aligned Arg238 not aligned Ala189 Cys191
1ps9(A)	1vys(X)	not aligned Arg233 not aligned His184 Tyr186
1ps9(A)	4h6k(A) 3rnd(A)	not aligned Arg243 not aligned Asn194 Tyr196
1ps9(A)	5nux(C,B,A,D)	not aligned Arg225 not aligned His175 Tyr177
1ps9(A)	5ogt(C,B,A,D)	not aligned Arg225 not aligned His175 Tyr177
1ps9(A)	6agz(B,A)	not aligned Arg239 not aligned His190 Tyr192
1ps9(A)	6de6(B,A)	not aligned Arg228 Ile352 His177 Phe179
1ps9(A)	6gi8(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	6gi9(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	6gia(A)	not aligned Arg234 not aligned His185 Tyr187
1ps9(A)	6myw(C,B,A,D)	not aligned Arg224 not aligned Asn175 Tyr177
1ps9(A)	6o08(A)	not aligned Arg224 not aligned Asn175 Tyr177
1ps9(A)	6qkg(B,A) 6qkr(B,A) 6qkx(A)	His284 Arg245 Gln372 Val195 Tyr197
1ps9(A)	6l6j(A)	not aligned Arg224 Ala349 His173 Leu175
1ps9(A)	6s0g(B) 6s23(B,A)	not aligned Arg246 not aligned Asn197 Tyr199
1ps9(A)	6s31(A)	not aligned Arg246 not aligned Asn197 Tyr199
1ps9(A)	6s32(C,B,A,D)	not aligned Arg250 not aligned Asn201 Tyr203
1ps9(A)	6uff(C,E,G,F,D,A,H,B)	not aligned Arg266 not aligned Asn217 Tyr219
1ps9(A)	7o0t(C,B,A,D)	not aligned Arg230 not aligned His180 Tyr182