M-CSA Mechanism and Catalytic Site Atlas

Ornithine carbamoyltransferase (M-CSA:12)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1oth

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1c9y(A), 1ep9(A), 1fvo(A, B)

PDB sequences homologous to 1oth

Reference PDB chains/ identical chains	Homologous PDB chains	His168(135)A Gln171(138)A Arg141(108)A Asp263(230)A Cys303(270)A Arg330(297)A
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3grf(A)	His134 Gln137 Arg107 Asp241 Cys282 Arg310
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4f2g(A)	His134 Gln137 Arg107 Asp223 Cys263 Arg291
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2atc(A)	His134 Gln137 Arg105 Thr220 Pro261 Gly287
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2ef0(A)	His134 Gln137 Arg107 Asp220 Cys260 Arg288
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1vlv(A)	His147 Gln150 Arg120 Asp243 Cys284 Arg312
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4e2f(C,E,G,I,A,K)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4a8p(E,C,F,D,A,B) 4a8h(B,A)	His130 Gln133 Arg103 Asp227 Cys269 Arg297
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3kzk(A) 3m4j(A) 3kzo(A) 3kzm(A) 3kzn(A) 3kzc(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4jhx(C,B,A) 4jfr(C,B,A) 4h31(C,B,A) 4kwt(C,B,A) 4jqo(C,B,A) 3upd(A)	His159 Gln162 Arg132 Asp257 Cys299 Arg344
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1gq3(C,B,A) 1i5o(C,A) 5vmq(C,B,A)	His134 Gln137 Ala105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2otc(C,E,G,F,D,I,A,H,B)	His133 Gln136 Arg106 Asp231 Cys273 Arg319
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3q98(A)	His168 Gln171 Arg125 Lys273 Cys333 Lys367
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4wto(C,A) 1f1b(C,A) 1ezz(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1sku(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3e2p(C,E,N,F,D,L,I,A,J,M,B,K) 2rgw(C,E,F,D,A,B) 4ekn(B)	His131 Gln134 Arg103 Thr225 Pro262 Gly288
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3txx(C,E,G,F,D,L,I,A,H,J,B,K)	His150 Gln153 Arg123 Asp247 Cys289 Arg317
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3tpf(E,C,F,D,A,B)	His125 Gln128 Arg98 Asp221 Cys261 Arg289
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2at2(C,B,A)	His127 Gln130 Arg99 Leu210 Pro249 Gly277
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4anf(C,B,A,D) 4amu(C,B,A,D)	His160 Gln163 Arg133 Asp258 Cys299 Arg351
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	8at1(C,A) 6at1(C,A) 5at1(C,A) 4at1(C,A) 1nbe(C,A) 3at1(C,A) 2at1(C,A) 1at1(C,A) 8atc(C,A) 7at1(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4nf2(C,B,A)	His159 Gln162 Arg132 Asp254 Cys293 Arg321
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3r7d(C,B,A) 3r7l(E,C,F,D,A,B) 3r7f(C,B,A)	His127 Gln130 Arg99 Leu210 Pro249 Gly277
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	His135 Gln138 Arg108 Asp230 Cys270 Arg297
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	5g1o(E,C,F,D,A,B) 5g1n(E,C,F,D,A,B) 5g1p(E,C,F,D,A,B)	His141 Gln144 Arg113 Thr234 Pro273 Gly299
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4iv5(C,E,F,D,A,B)	His149 Gln152 Arg121 Thr249 Pro295 Gly321
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4ep1(B,A)	His159 Gln162 Arg132 Asp254 Cys293 Arg321
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3lxm(C,B,A)	His159 Gln162 Arg130 Thr253 Pro291 Gly317
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1ort(E,C,G,F,D,L,I,A,H,J,B,K)	His134 Gln137 Arg107 Asp231 Cys273 Arg320
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	5iln(C,B,A)	His187 Gln190 Arg159 Thr294 Pro333 Gly359
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2hse(C,A) 2a0f(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2p2g(C,E,F,D,A,B) 2i6u(C,B,A)	His128 Gln131 Arg101 Asp224 Cys264 Arg292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3gd5(C,E,F,D,A,B)	His137 Gln140 Arg110 Asp232 Cys272 Arg300
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1js1(X,Y,Z)	His147 Gln150 Arg110 Lys236 Cys274 Arg302
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1acm(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1d09(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3mpu(E,A,C) 3npm(A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2be9(A)	His130 Gln133 Arg102 Thr221 Pro260 Gly286
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2g7m(C,E,Y,Z,X,D)	His167 Gln170 Arg130 Lys256 Cys294 Arg322
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1pvv(A)	His135 Gln138 Arg108 Asp230 Cys270 Arg298
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2w37(C,B,A)	His156 Gln159 Arg129 Asp252 Cys294 Arg339
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3m5c(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1fb5(A)	His134 Gln137 Arg107 Asp229 Cys269 Arg296
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3l04(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3sds(C,B,A)	His155 Gln158 Arg128 Asp265 Cys307 Arg334
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3l05(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1a1s(A)	His134 Gln137 Arg107 Asp229 Cys269 Arg297
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1dxh(A)	His134 Gln137 Arg107 Asp231 Cys273 Arg320
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1pg5(A)	His129 Gln132 Arg101 Thr220 Pro259 Gly285
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1ml4(A)	His135 Gln138 Arg107 Thr228 Pro267 Gly293
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4a8t(A)	His152 Gln155 Arg125 Asp249 Cys291 Arg319
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	5ilq(C,B,A) 6fba(C,B,A)	His151 Gln154 Arg123 Thr258 Pro297 Gly323
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3l06(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2be7(C,B,A)	His150 Gln153 Arg122 Thr244 Pro282 Gly308
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1xjw(C,A)	His134 Ala137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3l02(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2fzk(C,A) 1rac(C,A) 3csu(C,B,A) 1q95(E,C,F,D,A,B) 4fyy(C,A) 1r0b(C,E,F,D,A,B) 2air(A,G) 1raf(C,A) 1rag(C,A) 1rae(C,A) 2qg9(C,A) 1raa(C,A) 4fyx(C,A) 2ipo(C,A) 1rai(C,A) 3d7s(C,A) 1za1(C,A) 2fzg(C,A) 2h3e(C,A) 4kgz(C,A) 4kh1(C,A) 2qgf(C,A) 4kgv(C,A) 4kgx(C,A) 4fyv(C,A) 1rah(C,A) 2fzc(C,A) 4fyw(C,A) 1rab(C,A) 1za2(C,A) 1rad(C,A) 1r0c(A,G) 4f04(C,A) 4kh0(C,A) 6kjb(A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4am8(C,E,F,D,A,B)	His130 Gln133 Arg103 Asp227 Cys269 Arg297
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	4oh7(B,A)	His143 Gln146 Arg116 Asp234 Cys273 Arg301
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	2fg7(C,E,Y,Z,X,D) 2fg6(C,E,Y,Z,X,D)	His167 Gln170 Arg130 Lys256 Cys294 Arg322
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	5nnq(A) 5nnn(A)	His143 Gln146 Arg115 Thr237 Pro276 Gly302
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1tu0(C,A) 1tug(C,A) 1tth(C,A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1duv(I,G,H) 1akm(C,B,A)	His133 Gln136 Arg106 Asp231 Cys273 Arg319
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	9atc(A)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	1ekx(C,B,A)	His135 Gln138 Arg106 Thr229 Pro267 Gly293
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3m5d(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	3m4n(A)	His168 Gln171 Arg132 Lys272 Cys314 Arg342
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6hl7(C,B,A)	His151 Gln154 Arg123 Thr258 Pro297 Gly323
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6ovw(A)	His134 Gln137 Arg107 Asp232 Cys274 Arg320
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6jkq(C,E,F,D,A,B) 6jl4(C,E,F,D,A,B) 6jl6(C,E,F,D,A,B)	His142 Gln145 Arg114 Thr242 Pro288 Gly314
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6jkr(C,E,F,D,A,B) 6jks(C,E,F,D,A,B) 6jkt(C,E,F,D,A,B)	His143 Gln146 Arg115 Thr243 Pro289 Gly315
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6jl5(C,E,F,D,A,B)	His145 Gln148 Arg117 Thr245 Pro291 Gly317
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6kj7(A) 6kj8(C,A,E)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6kj9(C,E,F,D,A,B) 6kja(C,A,E)	His134 Gln137 Arg105 Thr228 Pro266 Gly292
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6ypo(B,A) 6ys6(C,B,A) 6ysp(C,B,A) 6yvb(C,E,F,D,A,B) 6yy1(C,E,F,D,A,B)	His157 Gln160 Arg129 Thr251 Pro291 Gly317
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	6yw9(C,B,A) 6ywj(B,A)	His157 Gln160 Arg129 Thr251 Pro291 Gly317
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	7k46(A)	His141 Gln144 Arg113 Thr241 Pro288 Gly314
1oth(A) 1fvo(B,A) 1c9y(A) 1ep9(A)	7nnf(C,E,F,D,A,B) 7nnv(C,E,F,D,A,B) 7nnw(C,E,F,D,A,B) 7nny(C,E,F,D,A,B) 7nnz(C,E,F,D,A,B) 7nor(C,E,F,D,A,B) 7nos(C,E,F,D,A,B) 7nou(C,E,F,D,A,B) 7nov(C,E,F,D,A,B) 7np0(C,E,F,D,A,B)	His130 Gln133 Arg103 Asp226 Cys266 Arg294