M-CSA Mechanism and Catalytic Site Atlas

Pyrogallol hydroxytransferase (M-CSA:146)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 4v4e

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1ati(Q1), 1cdu(q1), 1gbz(Q1), 1hi9(Bn), 1hl9(Q1), 1i9z(q1), 1ixx(q1), 1n06(Q1), 1pcq(q1), 1syr(81), 1t88(SA), 1un4(DP), 2eh4(Q1), 2iu7(Q1), 2j28(q1), 2j3w(81), 2o8h(Q1), 2ozt(Q1), 2qlc(Q1), 2tmk(q1), 2xni(h), 2yc4(q1), 2yq5(n), 2zkg(h), 2zvf(Q1), 3a3f(Q1), 3bdg(Bn), 3e0v(q1), 3fbt(q1), 3fxw(q1), 3hup(91), 3j3y(q1), 3j4f(91), 3j6x(81), 3j6y(81), 3j77(91), 3j78(91), 3j80(h), 3j81(h), 3jam(h), 3jan(q1), 3jap(h), 3jaq(h), 3js9(Q1), 3k5e(q1), 3m44(DP), 3tgo(q1), 3ttx(Q1), 3u9f(p), 3unf(q1), 3vhu(Q1), 3wai(Bq), 3we7(nn), 3zjf(Q1), 4ac8(q1), 4agt(q1), 4c5o(Q1), 4chk(SA), 4ffu(q1), 4g7o(q1), 4gml(Q1), 4hnz(Q1), 4ij2(q1), 4itj(Q1), 4j8e(q1), 4jdx(Q1), 4jin(q1), 4l16(SA), 4lo4(q1), 4lqc(Q1), 4qlv(Q1), 4qqp(Bn), 4u3m(q1, Q1), 4u3n(q1, Q1), 4u3u(q1, Q1), 4u4n(q1, Q1), 4u4o(q1, Q1), 4u4q(q1, Q1), 4u4r(q1, Q1), 4u4u(q1, Q1), 4u4y(q1, Q1), 4u4z(q1, Q1), 4u50(q1, Q1), 4u51(q1, Q1), 4u52(q1, Q1), 4u53(q1, Q1), 4u55(q1, Q1), 4u56(q1, Q1), 4u6f(q1, Q1), 4uh0(q1), 4v02(Q1), 4v4c(A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X), 4v4d(A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X), 4v52(q1), 4v6i(Bq), 4v72(n5), 4v88(Bn, Dn), 4v8i(q1), 4v8t(n), 4v8y(Bn), 4v8z(Bn), 4v91(n), 4wzo(Q1), 4zt2(h), 5dat(q1, Q1), 5dc3(q1, Q1), 5dge(q1, Q1), 5dgf(q1, Q1), 5dgv(q1, Q1), 5fci(q1, Q1), 5fcj(q1, Q1), 5gak(p), 5i4l(q1, Q1), 5if9(Q1), 5imq(Q1), 5it7(AO, nn), 5juo(SA), 5jup(SA), 5jus(SA), 5jut(SA), 5juu(SA), 5l8s(AS), 5lhn(h), 5lt3(SA), 5lyb(q1, Q1), 5m1j(n5), 5mc6(AS), 5mei(AO, DP), 5mvz(Q1), 5ndg(q1, Q1), 5ndv(q1, Q1), 5ndw(q1, Q1), 5ntp(n), 5o3l(SA), 5obm(q1, Q1), 5on6(AO, DP), 5sy1(Q1), 5tbw(AO, DP), 5tga(q1, Q1), 5tgm(q1, Q1), 5ti1(AO), 5upe(Dn), 5vy4(q1), 5xyi(n), 6fyx(h), 6fyy(h), 6gq1(n), 6gqb(n), 6gqv(n), 6gsm(h), 6gsn(h), 6hd7(p), 6hhq(AO, DP), 6i7o(AS, XS), 6q8y(AS), 6s47(Ap), 6snt(ac), 6sv4(AS, XS, zS), 6t4q(Ln), 6t7i(Ln), 6t7t(Ln), 6t83(nb, Y), 6tb3(AS), 6tnu(AS), 6xiq(n), 6xir(n), 6z6j(Ln), 6z6k(Ln), 7b7d(Lj), 7nrc(Lp), 7nrd(Lp)

PDB sequences homologous to 4v4e

Reference PDB chains/ identical chains	Homologous PDB chains	His144A Tyr404A Asp174A
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1fdo(A) 1aa6(A) 1fdi(A) 2iv2(X)	Arg110 Gln335 not aligned
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	2vpw(E,A) 2vpz(E,A) 2vpx(E,A) 2vpy(E,A)	not aligned Tyr364 Asp149
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5e7o(C,E,G,I,A,K)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1dms(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1eu1(A)	Trp116 Tyr360 Asp145
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	His144 Tyr404 Asp174
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	4dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	3dmr(A) 1h5n(C,A) 1dmr(A) 1e5v(C,A) 2dmr(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e60(C,A) 1e61(C,A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	5chc(E,A,C) 5ch7(C,A,E) 4ydd(E,A,C)	Pro140 Tyr457 Asp170
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1e18(A)	Trp158 Tyr402 Asp187
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	1tmo(A)	Trp149 Tyr397 Asp178
4v4e(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4d(E,C,W,G,O,S,I,A,Q,M,U,K) 4v4c(E,C,W,G,O,S,I,A,Q,M,U,K)	7l5i(A) 7l5s(A)	Trp144 Tyr388 Asp173