M-CSA Mechanism and Catalytic Site Atlas

Peptidyl-dipeptidase A (M-CSA:170)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1o8a

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1o86(A), 1uze(A), 1uzf(A), 4aph(A), 4apj(A), 4bzr(A), 4ca5(A)

PDB sequences homologous to 1o8a

Reference PDB chains/ identical chains	Homologous PDB chains	His387(351)A Ala354(318)A (main-C) Glu411(375)A His353(317)A His513(477)A Tyr523(487)A Glu384(348)A His383(347)A
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	5amc(A)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2xy9(A)	His348 Ala315 Glu372 His314 His474 Tyr484 Glu345 His344
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4c2n(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2ydm(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2iul(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4c2r(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4ca6(A,B) 2xyd(A,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2iux(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2x92(A) 2x93(A) 2x94(A) 2x95(A)	His355 Ala322 Glu379 His321 His481 Tyr491 Glu352 His351
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3scj(A,B) 3sci(A,B) 6acg(D) 6acj(D) 6ack(D) 6m0j(A)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3d0g(A,B) 3d0h(A,B) 3d0i(A,B)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3bkk(A) 3bkl(A) 3l3n(A) 6f9t(A) 6f9u(A) 6h5w(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	1r4l(A) 1r42(A)	His378 Pro346 Glu402 His345 His505 Tyr515 Glu375 His374
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	1j38(A,B) 1j37(A,B) 1j36(A,B)	His358 Ala325 Glu382 His324 His484 Tyr494 Glu355 His354
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3zqz(A) 2x91(A) 2x8y(A) 4asq(A) 4ca8(A) 2x8z(A) 4asr(A) 2x97(A) 2x96(A) 2xhm(A) 2x90(A) 4aa2(A) 4ca7(A) 4aa1(A)	His355 Ala322 Glu379 His321 His481 Tyr491 Glu352 His351
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4c2o(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3kbh(D,A,C,B) 2ajf(A,B) 6vw1(A,B) 7ddo(A) 7ddp(A) 7dx4(A) 7kmb(F) 7kms(F,E,D) 7kmz(D,E) 7knb(D) 7kne(D) 7knh(D,E) 7kni(F,E,D) 7l0n(F,E)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	5ama(C,A,D,B) 5am9(D,A,C,B) 4ufa(A,B) 4ufb(D,A,C,B) 4bxk(A,B) 3nxq(A,B) 5amc(B) 5amb(A,B) 6en5(C,A,D,B) 6en6(C,A,D,B) 6qs1(A,B) 6zpq(D,A,C,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	5a2r(A)	His354 Ala321 Glu378 His320 His480 Tyr490 Glu351 His350
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2c6n(A,B) 2c6f(A,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	5am8(D,A,C,B) 6f9v(A,B) 6f9r(A,B) 6h5x(A,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	2oc2(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4c2q(A) 4c2p(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	4bzs(A,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	3sck(A,B) 3scl(A,B)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6cs2(D)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6s1y(A) 6s1z(A)	His361 Ala328 Glu385 His327 His487 Tyr497 Glu358 His357
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6lzg(A) 7lo4(A)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6m17(D,B) 6m18(D,B) 6m1d(D,B)	His387 Pro355 Glu411 His354 His514 Tyr524 Glu384 His383
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6tt1(A,B) 6tt3(A,B) 6tt4(A,B) 6zpt(D,A,C,B)	His365 Ala332 Glu389 His331 His491 Tyr501 Glu362 His361
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	6zpu(A)	His351 Ala318 Glu375 His317 His477 Tyr487 Glu348 His347
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7a91(D) 7a92(D) 7a94(D) 7a95(D) 7a96(D) 7a97(E,D) 7a98(F,E,D)	His380 Pro348 Glu404 His347 His507 Tyr517 Glu377 His376
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7bh9(A)	His362 Pro330 Glu386 His329 His489 Tyr499 Glu359 His358
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7c8d(A)	His362 Pro330 Glu386 His329 His489 Tyr499 Glu359 His358
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7c8j(A)	His359 Pro327 Glu383 His326 His486 Tyr496 Glu356 His355
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7c8k(A)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7ct5(F,E,D)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7df4(A)	His379 Pro347 Glu403 His346 His506 Tyr516 Glu376 His375
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7dmu(A,C)	His361 Pro329 Glu385 His328 His488 Tyr498 Glu358 His357
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7dwx(D,B) 7dx5(D) 7dx6(D) 7dx7(D) 7dx8(E,D) 7dx9(E,D)	His390 Pro358 Glu414 His357 His517 Tyr527 Glu387 His386
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7e3j(A)	His361 Pro329 Glu385 His328 His488 Tyr498 Glu358 His357
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7kj2(D) 7kj3(E,D) 7kj4(F,E,D)	His368 Pro336 Glu392 His335 His495 Tyr505 Glu365 His364
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7l7f(D,B)	His378 Pro346 Glu402 His345 His505 Tyr515 Glu375 His374
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7mjm(E,D) 7mjn(E)	His361 Pro329 Glu385 His328 His488 Tyr498 Glu358 His357
1o8a(A) 4aph(A) 1uze(A) 4bzr(A) 1o86(A) 4ca5(A) 4apj(A) 1uzf(A)	7nxc(A)	His360 Pro328 Glu384 His327 His487 Tyr497 Glu357 His356