M-CSA Mechanism and Catalytic Site Atlas

HIV-1 retropepsin (M-CSA:175)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P04585

Reference Sequence	Homologue	Gly515 (main-N) Asp513 Thr514 Thr514 Gly515 (main-N) Asp513
P04585	P03369	Gly517 Asp515 Thr516 Thr516 Gly517 Asp515
P04585	P04585	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P11283	Gly773 Asp771 Thr772 Thr772 Gly773 Asp771
P04585	Q1A250	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P23074	Gly26 Asp24 Ser25 Ser25 Gly26 Asp24
P04585	Q9QC07	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9QSR3	Gly509 Asp507 Thr508 Thr508 Gly509 Asp507
P04585	Q87040	Gly26 Asp24 Ser25 Ser25 Gly26 Asp24
P04585	Q9YNA8	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P04588	Gly520 Asp518 Thr519 Thr519 Gly520 Asp518
P04585	Q5R5R5	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	P63132	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P03348	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P87889	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P63145	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P10266	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P53996	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	P63126	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	Q0R5R2	Gly464 Asp462 Thr463 Thr463 Gly464 Asp462
P04585	P04589	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	Q1A268	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P62685	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P63136	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q8AII1	Gly542 Asp540 Thr541 Thr541 Gly542 Asp540
P04585	Q04095	Gly616 Asp614 Ser615 Ser615 Gly616 Asp614
P04585	P62683	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P05961	Gly521 Asp519 Thr520 Thr520 Gly521 Asp519
P04585	P18095	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05888	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P18096	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P03363	Gly480 Asp478 Thr479 Thr479 Gly480 Asp478
P04585	P04591	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O93209	Gln23 Asp21 Ser22 Ser22 Gln23 Asp21
P04585	P03366	Gly527 Asp525 Thr526 Thr526 Gly527 Asp525
P04585	P63133	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9WJR5	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	A1Z651	Gly566 Asp564 Thr565 Thr565 Gly566 Asp564
P04585	P63128	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	Q1A249	Gly524 Asp522 Thr523 Thr523 Gly524 Asp522
P04585	O92815	Gly625 Asp623 Thr624 Thr624 Gly625 Asp623
P04585	Q7LDI9	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P14078	Gly483 Asp481 Thr482 Thr482 Gly483 Asp481
P04585	Q9HDB9	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	P63135	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9QSR4	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04594	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P63130	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	Q9UQG0	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O42395	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	Q89703	Gly28 Asp26 Thr27 Thr27 Gly28 Asp26
P04585	P03367	Gly527 Asp525 Thr526 Thr526 Gly527 Asp525
P04585	Q3T0Q6	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	Q9BXR3	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P62633	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	Q8AII2	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04592	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P03355	Gly568 Asp566 Thr567 Thr567 Gly568 Asp566
P04585	P14350	Gly26 Asp24 Ser25 Ser25 Gly26 Asp24
P04585	P62634	not aligned not aligned Thr21 Thr21 not aligned not aligned
P04585	P62684	Gly53 Glu43 Glu51 Glu51 Gly53 Glu43
P04585	Q1A267	Gly514 Asp512 Thr513 Thr513 Gly514 Asp512
P04585	P03347	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O12158	Gly511 Asp509 Thr510 Thr510 Gly511 Asp509
P04585	O92956	Gly616 Asp614 Ser615 Ser615 Gly616 Asp614
P04585	P03349	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P03354	Gly616 Asp614 Ser615 Ser615 Gly616 Asp614
P04585	P03362	Gly483 Asp481 Thr482 Thr482 Gly483 Asp481
P04585	P03365	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04584	Gly540 Asp538 Thr539 Thr539 Gly540 Asp538
P04585	P04586	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04587	Gly527 Asp525 Thr526 Thr526 Gly527 Asp525
P04585	P04590	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05889	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05893	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05896	Gly524 Asp522 Thr523 Thr523 Gly524 Asp522
P04585	P05897	Gly524 Asp522 Thr523 Thr523 Gly524 Asp522
P04585	P05959	Gly516 Asp514 Thr515 Thr515 Gly516 Asp514
P04585	P07570	Gly190 Asp188 Thr189 Thr189 Gly190 Asp188
P04585	P0C6F2	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P11204	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12493	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12495	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12497	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P12499	Gly516 Asp514 Thr515 Thr515 Gly516 Asp514
P04585	P16087	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P16088	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P18041	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P18042	Gly540 Asp538 Thr539 Thr539 Gly540 Asp538
P04585	P19505	Gly525 Asp523 Thr524 Thr524 Gly525 Asp523
P04585	P19560	Gly499 Asp497 Thr498 Thr498 Gly499 Asp497
P04585	P20875	Gly519 Asp517 Thr518 Thr518 Gly519 Asp517
P04585	P24740	Gly508 Asp506 Thr507 Thr507 Gly508 Asp506
P04585	P32542	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P35956	Gly61 Asp59 Thr60 Thr60 Gly61 Asp59
P04585	P35962	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P35963	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P69732	not aligned Asp96 Ser100 Ser100 not aligned Asp96
P04585	Q02843	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q2F7J3	Gly566 Asp564 Thr565 Thr565 Gly566 Asp564
P04585	Q70622	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9WC62	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P03356	Gly567 Asp565 Thr566 Thr566 Gly567 Asp565
P04585	O12157	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q74230	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9WC63	Gly512 Asp510 Thr511 Thr511 Gly512 Asp510
P04585	P07572	Gly787 Asp785 Thr786 Thr786 Gly787 Asp785
P04585	O91080	Gly525 Asp523 Thr524 Thr524 Gly525 Asp523
P04585	Q7SVK7	Gly567 Asp565 Thr566 Thr566 Gly567 Asp565
P04585	P05894	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P20876	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P18802	Gly512 Asp510 Thr511 Thr511 Gly512 Asp510
P04585	O89291	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q74120	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	Q75001	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O93182	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P23427	Gly466 Asp464 Thr465 Thr465 Gly466 Asp464
P04585	P11227	Gly567 Asp565 Thr566 Thr566 Gly567 Asp565
P04585	P12494	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P35955	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12894	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P19504	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P03361	Gly454 Asp452 Thr453 Thr453 Gly454 Asp452
P04585	Q9QBZ1	Gly514 Asp512 Thr513 Thr513 Gly514 Asp512
P04585	P27978	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9WC54	Gly512 Asp510 Thr511 Thr511 Gly512 Asp510
P04585	P23425	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q74119	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P20892	Gly514 Asp512 Thr513 Thr513 Gly514 Asp512
P04585	Q9WC53	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P51517	Gly784 Asp782 Thr783 Thr783 Gly784 Asp782
P04585	P27980	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P12450	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q05313	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04025	Gly788 Asp786 Thr787 Thr787 Gly788 Asp786
P04585	P16900	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O91079	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O89290	Gly510 Asp508 Thr509 Thr509 Gly510 Asp508
P04585	P15833	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P03370	Gly466 Asp464 Thr465 Thr465 Gly466 Asp464
P04585	P26809	Gly568 Asp566 Thr567 Thr567 Gly568 Asp566
P04585	P03360	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q73368	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	O41798	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P05960	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P05892	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q2F7J0	Gly566 Asp564 Thr565 Thr565 Gly566 Asp564
P04585	O89939	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9Q721	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P17283	Gly464 Asp462 Thr463 Thr463 Gly464 Asp462
P04585	P03359	Gly551 Asp549 Thr550 Thr550 Gly551 Asp549
P04585	Q9IDV9	Gly525 Asp523 Thr524 Thr524 Gly525 Asp523
P04585	P17756	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05890	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9QBZ5	Gly510 Asp508 Thr509 Thr509 Gly510 Asp508
P04585	P22382	Gly520 Asp518 Thr519 Thr519 Gly520 Asp518
P04585	P31634	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P27401	Gly26 Asp24 Ser25 Ser25 Gly26 Asp24
P04585	P22381	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P26808	Gly568 Asp566 Thr567 Thr567 Gly568 Asp566
P04585	P20873	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P18800	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q76633	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q79665	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q82851	Gly459 Asp457 Thr458 Thr458 Gly459 Asp457
P04585	Q75002	Gly519 Asp517 Thr518 Thr518 Gly519 Asp517
P04585	Q9QBY4	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P24107	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P31822	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P21414	Gly550 Asp548 Thr549 Thr549 Gly550 Asp548
P04585	O89940	Gly513 Asp511 Thr512 Thr512 Gly513 Asp511
P04585	P03364	Gly870 Asp868 Thr869 Thr869 Gly870 Asp868
P04585	Q9QBY3	Gly510 Asp508 Thr509 Thr509 Gly510 Asp508
P04585	Q9QBZ9	Gly510 Asp508 Thr509 Thr509 Gly510 Asp508
P04585	P05887	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P23426	Gly466 Asp464 Thr465 Thr465 Gly466 Asp464
P04585	P11365	not aligned Lys24 not aligned not aligned not aligned Lys24
P04585	P12451	Gly538 Asp536 Thr537 Thr537 Gly538 Asp536
P04585	Q9QBZ2	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P08361	Gly566 Asp564 Thr565 Thr565 Gly566 Asp564
P04585	Q76634	Gly539 Asp537 Thr538 Thr538 Gly539 Asp537
P04585	P27973	Gly538 Asp536 Thr537 Thr537 Gly538 Asp536
P04585	P24736	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05891	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P26810	Gly569 Asp567 Thr568 Thr568 Gly569 Asp567
P04585	Q89928	Gly537 Asp535 Thr536 Thr536 Gly537 Asp535
P04585	P12501	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P10272	Gly567 Asp565 Thr566 Thr566 Gly567 Asp565
P04585	P03371	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P23424	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P20874	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P17282	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P05962	Arg537 Asp535 Thr536 Thr536 Arg537 Asp535
P04585	P11368	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P33458	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q77373	Gly514 Asp512 Thr513 Thr513 Gly514 Asp512
P04585	P19558	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P31792	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P16901	Gly46 Asp44 Thr45 Thr45 Gly46 Asp44
P04585	Q9IDV8	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12502	Gly525 Asp523 Thr524 Thr524 Gly525 Asp523
P04585	Q4U0X6	Gly464 Asp462 Thr463 Thr463 Gly464 Asp462
P04585	P31821	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q9QBZ6	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q77372	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	O93215	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	P27972	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P10273	Gly536 Asp534 Thr535 Thr535 Gly536 Asp534
P04585	P12498	Gly515 Asp513 Thr514 Thr514 Gly515 Asp513
P04585	Q9TTC1	Gly551 Asp549 Thr550 Thr550 Gly551 Asp549
P04585	P25059	Gly454 Asp452 Thr453 Thr453 Gly454 Asp452
P04585	P0C1K7	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P24106	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P33459	Gly70 Asp68 Thr69 Thr69 Gly70 Asp68
P04585	Q82850	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12500	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P15832	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P17757	Gly538 Asp536 Thr537 Thr537 Gly538 Asp536
P04585	Q7SQ98	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q79666	Gly516 Asp514 Thr515 Thr515 Gly516 Asp514
P04585	P20889	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P12496	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P19028	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P31623	Gly741 Asp739 Thr740 Thr740 Gly741 Asp739
P04585	P03352	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P0C211	Gly483 Asp481 Thr482 Thr482 Gly483 Asp481
P04585	P04593	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P69730	not aligned Asp96 Ser100 Ser100 not aligned Asp96
P04585	Q9Q720	Gly516 Asp514 Thr515 Thr515 Gly516 Asp514
P04585	Q9QC00	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P04026	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q73367	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	P19027	not aligned not aligned not aligned not aligned not aligned not aligned
P04585	Q02836	Gly531 Asp529 Thr530 Thr530 Gly531 Asp529
P04585	P05895	Gly542 Asp540 Thr541 Thr541 Gly542 Asp540
P04585	P04024	Gly788 Asp786 Thr787 Thr787 Gly788 Asp786
P04585	P31625	Gly741 Asp739 Thr740 Thr740 Gly741 Asp739
P04585	P69731	not aligned Asp96 Ser100 Ser100 not aligned Asp96
P04585	P51518	Gly784 Asp782 Thr783 Thr783 Gly784 Asp782