M-CSA Mechanism and Catalytic Site Atlas

Thermolysin (M-CSA:176)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1kei

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1kjo(A), 1kjp(A), 1kkk(A), 1kl6(A), 1kr6(A), 1kro(A), 1ks7(A), 1kto(A), 1y3g(E), 2whz(A), 2wi0(A), 3dnz(A), 3do0(A), 3do1(A), 3do2(A), 3fb0(A), 3fbo(A), 3fgd(A), 3flf(A), 3fv4(A), 3fvp(A), 3fxp(A), 3fxs(A), 3ls7(A), 3ms3(A), 3msa(A), 3msf(A), 3msn(A), 3n21(A), 3nn7(A), 3qgo(A), 3qh1(A), 3qh5(A), 3ssb(A, B), 3t73(A), 3t74(A), 3t87(A), 3t8c(A), 3t8d(A), 3t8f(A), 3t8g(A), 3t8h(A), 4d91(A), 4d9w(A), 4h57(A), 4mtw(E), 4mwp(E), 4mxj(E), 4mzn(E), 4n4e(E), 4n5p(E), 4n66(E), 4oi5(E), 4ow3(A), 4tnl(A), 5dlh(A), 5dpe(E), 5dpf(E), 5fsj(A), 5fsp(A), 5fss(A), 5js3(E), 5jss(E), 5jt9(E), 5jvi(E), 5jxn(E), 5k7t(A), 5l3u(E), 5l41(E), 5l8p(E), 5lif(E), 5lvd(E), 5lwd(E), 5m5f(E), 5m69(E), 5m9w(A), 5ma7(E), 5mnr(E), 5n2t(E), 5n2x(E), 5n2z(E), 5n31(E), 5n34(E), 5n3v(E), 5n3y(E), 5o8n(A), 5onp(A), 5onq(A), 5onr(A), 5t9i(A), 5t9k(A), 5t9q(A), 5tac(A), 5tad(A), 5tae(A), 5tai(A), 5taj(A), 5tak(A), 5un3(A), 5uu7(A), 5uu8(A), 5uu9(A), 5uua(A), 5uub(A), 5uuc(A), 5uud(A), 5uue(A), 5wr2(A), 5wr3(A), 5wr4(A), 5wr5(A), 5wr6(A), 6d5n(A), 6d5o(A), 6d5p(A), 6d5q(A), 6d5r(A), 6d5s(A), 6d5t(A), 6d5u(A), 6fj2(A), 6ghx(A), 6ig7(A), 6lzn(A), 6lzo(A), 6n4w(A), 6n4z(A), 6qar(A), 6qf2(A), 6qf3(A), 6sb9(E), 6sbk(E), 6sc0(E), 6sc1(E), 6sc3(E), 6sck(E), 6scu(E), 6sel(A), 6y4i(E), 6yi6(E), 6ymr(E), 6yms(E), 6zhj(A), 7akn(A)

PDB sequences homologous to 1kei

Reference PDB chains/ identical chains	Homologous PDB chains	His146A Tyr157A His142A Asp226A His231A Glu143A Glu166A
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	3nqx(A)	His145 Tyr156 His141 Asp222 His224 Glu142 Glu165
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	4m65(A)	His146 Tyr157 His142 Asp226 His231 Glu143 Glu166
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	4k89(A)	His144 Tyr155 His140 Asp221 His223 Glu141 Glu164
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1trl(B,A) 6fhp(C,D)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	3nqz(B)	His145 Tyr156 His141 Asp222 His224 Glu142 Ala165
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1fjq(A) 3p7s(E) 1fjv(A) 3eim(A) 3zi6(A) 5tln(A) 1tlp(E) 5tli(A) 1tmn(E) 1qf2(A) 3p7r(E) 3p7q(E) 3tli(A) 3p7t(E) 8tli(A) 1tlx(A) 1hyt(A) 1lnc(E) 1fjt(A) 1qf0(A) 3f2p(A) 1lnf(E) 3p7v(E) 1l3f(E) 1gxw(A) 3f28(A) 8tln(E) 5tmn(E) 1os0(A) 3t2i(E) 2tlx(A) 1fjo(A) 7tln(A) 2g4z(A) 1pe5(A) 3t2h(E) 1fj3(A) 1lne(E) 6tli(A) 3p7w(E) 1fjw(A) 2a7g(E) 6tmn(E) 7tli(A) 1lnb(E) 3for(A) 5hqd(A) 1zdp(E) 2tmn(E) 3p7p(E) 1lna(E) 2tli(A) 1fju(A) 3fcq(A) 1thl(A) 1lnd(E) 1z9g(E) 4tli(A) 3p7u(E) 3t2j(E) 1tli(A) 4tmn(E) 1pe8(A) 1pe7(A) 4tln(A) 1qf1(A) 3tmn(E) 6fsm(A)	His146 Tyr157 His142 Asp226 His231 Glu143 Glu166
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	3nqy(B)	His145 Tyr156 His141 Asp222 His224 Ala142 Glu165
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	5fxn(A)	His145 Tyr156 His141 Asp225 His230 Glu142 Glu165
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1esp(A)	His147 Tyr158 His143 Asp227 His232 Ser144 Glu167
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1npc(A)	His147 Tyr158 His143 Asp227 His232 Glu144 Glu167
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1bqb(A)	His148 Tyr159 His144 Asp223 His228 Glu145 Glu168
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	His146 Tyr157 His142 Asp226 His231 Glu143 Glu166
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	2vqx(A)	His166 Tyr177 His162 Asp259 His264 Ala163 Glu186
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	4ger(B,A) 4b52(B,A)	His139 Tyr150 His135 Asp214 His219 Glu136 Glu159
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	1u4g(A) 3dbk(A) 1ezm(A) 6f8b(A) 6fzx(A) 7ajr(AAA)	His144 Tyr155 His140 Asp221 His223 Glu141 Glu164
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	5a3y(A)	His378 Tyr389 His374 Asp458 His463 Glu375 Glu398
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	6ya1(A) 6yze(A)	His174 Tyr185 His170 Asp254 His256 Glu171 Glu194
1kei(A) 4mwp(E) 3t74(A) 1kr6(A) 3fb0(A) 3qh5(A) 3n21(A) 3t87(A) 3ls7(A) 5uub(A) 3qh1(A) 5fss(A) 1kjp(A) 5n34(E) 5uu9(A) 5lwd(E) 4mxj(E) 1kl6(A) 5uu8(A) 4mzn(E) 2whz(A) 3fvp(A) 5l41(E) 5dpf(E) 5jxn(E) 5jt9(E) 3fgd(A) 5jss(E) 5lif(E) 5dpe(E) 3fxp(A) 1kkk(A) 5uud(A) 3do1(A) 4n5p(E) 2wi0(A) 4ow3(A) 5uue(A) 5n2t(E) 3nn7(A) 3fv4(A) 3msa(A) 4d9w(A) 3t8g(A) 3t8h(A) 3ssb(B,A) 1y3g(E) 3fbo(A) 5fsp(A) 4d91(A) 4n4e(E) 5jvi(E) 1kto(A) 3do2(A) 1kjo(A) 5t9k(A) 5js3(E) 5uuc(A) 3t8d(A) 3t8f(A) 3t73(A) 3t8c(A) 5o8n(A) 5n3y(E) 4tnl(A) 5uua(A) 5fsj(A) 5k7t(A) 5n31(E) 3msn(A) 3fxs(A) 5l3u(E) 3qgo(A) 3do0(A) 1ks7(A) 4h57(A) 5un3(A) 5l8p(E) 3ms3(A) 5n2x(E) 4mtw(E) 5dlh(A) 5n2z(E) 5n3v(E) 5mnr(E) 3dnz(A) 1kro(A) 4oi5(E) 3msf(A) 4n66(E) 5uu7(A) 3flf(A) 5t9i(A) 5wr2(A) 5t9q(A) 5m5f(E) 5tad(A) 5m9w(A) 5taj(A) 5tac(A) 5tak(A) 5tai(A) 5m69(E) 5wr5(A) 5ma7(E) 5wr4(A) 5lvd(E) 5wr3(A) 5wr6(A) 5tae(A) 6fj2(A) 5onp(A) 5onq(A) 5onr(A) 6d5n(A) 6d5o(A) 6d5p(A) 6d5q(A) 6d5r(A) 6d5s(A) 6d5t(A) 6d5u(A) 6ghx(A) 6ig7(A) 6n4w(A) 6n4z(A) 6qf2(A) 6qf3(A) 6sel(A) 6lzn(A) 6lzo(A) 6qar(A) 6sb9(E) 6sbk(E) 6sc0(E) 6sc1(E) 6sc3(E) 6sck(E) 6scu(E) 6y4i(E) 6yi6(E) 6ymr(E) 6yms(E) 6zhj(A) 7akn(A)	7ecc(A)	His145 Tyr156 His141 Asp222 His224 Glu142 Glu165