M-CSA Mechanism and Catalytic Site Atlas

Geranyltranstransferase (M-CSA:253)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences homologous to 1fps

Reference PDB chains/ identical chains	Homologous PDB chains	Asp121(102)A Asp257(238)A Asp258(239)A Lys214(195)A Phe112(93)A Phe253(234)A Lys71(52)A Asp117(98)A Arg126(107)A Asp188(169)A
1fps(A)	2ogd(B,A) 3dyf(B,A) 2ewg(B,A) 4rxe(B,A) 3efq(B,A) 4rxd(C,B,A) 4ryp(B,A) 3dyh(B,A) 3dyg(B,A) 4rxc(B,A) 2p1c(B,A) 2i19(B,A)	Asp130 Asp278 Asp279 Lys235 His121 Phe274 Lys70 Asp126 Arg135 Asp198
1fps(A)	3cp6(A)	Asp130 Asp266 Asp267 Lys223 Phe121 Phe262 Lys80 Asp126 Arg135 Asp197
1fps(A)	3egt(B,A)	Asp153 Asp301 Asp302 Lys258 His144 Phe297 Lys93 Asp149 Arg158 Asp221
1fps(A)	2opm(A) 1yv5(A) 1yq7(A) 2opn(A)	Asp128 Asp264 Asp265 Lys221 Phe119 Phe260 Lys78 Asp124 Arg133 Asp195
1fps(A)	4h5e(F) 4lfv(F) 4pvy(F) 4h5c(F) 4h5d(F) 4nfj(F) 5jv1(F) 4pvx(F) 5juz(F) 5jv0(F) 4jvj(F) 5ja0(F) 5ksx(F) 4lph(F) 4nfk(F) 4dem(F) 5jv2(F) 4xqr(F) 4l2x(F) 4xqs(F) 4qpf(A) 4xqt(F) 4lpg(F) 4qxs(F) 4nfi(F) 6n7y(F) 6n7z(F) 6n82(F) 6n83(F) 6oag(F) 6oah(F)	Asp129 Asp265 Asp266 Lys222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	5ahu(B,D)	Asp34 Asp182 Asp183 Lys139 His25 Phe178 not aligned Asp30 Arg39 Asp102
1fps(A)	4p0w(A) 4rxa(A) 4p0x(A) 4ga3(A) 4n1z(F) 5ygi(A)	Asp102 Asp238 Asp239 Lys195 Phe93 Phe234 Lys52 Asp98 Arg107 Asp169
1fps(A)	6b02(B,A) 6b07(C,B,A) 6b06(C,B,A) 6b04(C,B,A)	Asp95 Asp231 Asp232 Lys188 Phe86 Phe227 Lys45 Asp91 Arg100 Asp162
1fps(A)	2f7m(F) 5dgm(F) 3n46(F) 3n3l(F) 3n5h(F) 2f94(F) 5djv(F) 2f9k(F) 3n6k(F) 5djp(F) 3n1v(F) 3n5j(F) 5dgn(F) 2f92(F) 2f89(F) 5djr(F) 3n45(F) 2f8z(F) 3n49(F) 5diq(F) 2f8c(F) 5dgs(F) 3n1w(F)	Asp104 Asp240 Asp241 Lys197 Phe95 Phe236 Lys54 Asp100 Arg109 Asp171
1fps(A)	3mav(C,B,A,D)	Asp129 Asp286 Asp287 Lys242 Ala120 Phe282 Lys80 Asp125 Arg134 Asp197
1fps(A)	5ael(B,A) 5afx(B,A)	Asp107 Asp255 Asp256 Lys212 His98 Phe251 Lys47 Asp103 Arg112 Asp175
1fps(A)	4ogu(A) 4nke(A) 4nkf(A)	Asp129 Asp265 Asp266 Lys222 Phe120 Ala261 Lys79 Asp125 Arg134 Asp196
1fps(A)	3icn(A) 4dwg(A) 4dxj(C,B,A) 1yhk(A) 1yhm(C,B,A) 3iba(A) 3icz(A) 1yhl(A) 3ick(A) 4dwb(A) 3id0(A) 4dzw(A) 3icm(A)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	2rah(A) 2vf6(A)	Asp132 Asp268 Asp269 Lys225 Phe123 Phe264 Lys82 Asp128 Arg137 Asp199
1fps(A)	1wmw(C,B,A,D)	Asp83 Asp212 Asp213 Lys172 Trp74 Phe208 Lys40 Asp79 Arg88 Asp149
1fps(A)	5cg5(A) 5cg6(A)	Asp101 Asp237 Asp238 Lys194 Phe92 Phe233 Lys51 Asp97 Arg106 Asp168
1fps(A)	1fps(A)	x x x x x x x x x x
1fps(A)	3b7l(A)	Asp110 Asp246 Asp247 Lys203 Phe101 Phe242 Lys60 Asp106 Arg115 Asp177
1fps(A)	4kk2(B,A)	Asp121 Asp256 Asp257 Lys214 Tyr112 Phe252 Lys72 Asp117 Arg126 Asp188
1fps(A)	4kkm(B,A)	Asp114 Asp247 Asp248 Lys206 Tyr103 Phe243 Lys69 Asp108 Arg119 Asp184
1fps(A)	3lk5(A) 3qqv(A)	Asp112 Asp257 Asp258 Lys215 Cys103 Phe253 Lys63 Asp108 Arg117 Asp194
1fps(A)	4q23(A) 4kfa(A)	Asp129 Asp265 Asp266 Lys222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	1ubx(A)	Asp121 Asp257 Asp258 Lys214 Ala112 Phe253 Lys71 Asp117 Arg126 Asp188
1fps(A)	4nua(A)	Asp129 Asp265 Asp266 Lys222 Phe120 Ala261 Lys79 Asp125 Arg134 Asp196
1fps(A)	1zw5(A)	Asp109 Asp245 Asp246 Lys202 Phe100 Phe241 Lys59 Asp105 Arg114 Asp176
1fps(A)	2o1o(B,A) 2q58(B,A)	Asp119 Asn254 Asp255 Lys210 Leu110 Tyr250 Lys72 Asp115 Arg124 Asp187
1fps(A)	2qis(A)	Asp128 Asp264 Asp265 Lys221 Phe119 Phe260 Lys78 Asp124 Arg133 Asp195
1fps(A)	4kpd(A)	Asp129 Asp265 Asp266 Lys222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	4e1e(A)	Asp101 Asp249 Asp250 Lys206 His92 Phe245 Lys47 Asp97 Arg106 Asp169
1fps(A)	4ng6(A)	Asp129 Asp265 Asp266 Leu222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	4k10(C,B,A,D) 4jzx(B,A) 4jzb(B,A)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	3ez3(C,B,A,D) 3ldw(C,B,A,D) 3rbm(C,B,A,D) 3cc9(C,B,A,D) 3ph7(C,B,A,D) 3ryw(C,B,A,D)	Asp130 Asp287 Asp288 Lys243 Ala121 Phe283 Lys81 Asp126 Arg135 Asp198
1fps(A)	5hn9(C,B,A,D) 5hn7(E,C,G,F,D,A,H,B) 5hn8(C,B,A,D) 5hna(C,B,A,D)	Asp109 Asp266 Asp267 Lys222 Ala100 Phe262 Lys60 Asp105 Arg114 Asp177
1fps(A)	1uby(A) 1ubv(A) 1ubw(A)	Asp121 Asp257 Asp258 Lys214 Ala112 Phe253 Lys71 Asp117 Arg126 Asp188
1fps(A)	3rye(A) 3s4j(A)	Asp103 Asp239 Asp240 Lys196 Phe94 Phe235 Lys53 Asp99 Arg108 Asp170
1fps(A)	4kqs(A) 4kpj(A) 4kq5(A) 4kqu(A)	Asp129 Asp265 Asp266 Lys222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	4n9u(A)	Asp129 Asp265 Asp266 Gly222 Phe120 Phe261 Lys79 Asp125 Arg134 Asp196
1fps(A)	4p0v(A)	Asp101 Asp237 Asp238 Lys194 Phe92 Phe233 Lys51 Asp97 Arg106 Asp168
1fps(A)	6kd7(A)	Asp83 Asp209 Asp210 Lys168 Phe74 Phe205 Lys40 Asp79 Arg88 Asp147
1fps(A)	5qpd(A) 5qpe(A) 5qpf(A) 5qpg(A) 5qph(A) 5qpi(A) 5qpj(A) 5qpk(A) 5qpl(A) 5qpm(A) 5qpn(A) 5qpo(A) 5qpp(A) 5qpq(A) 5qpr(A) 5qps(A) 5qpt(A) 5qpu(A) 5qpv(A) 5qpw(A) 5qpx(A) 5qpy(A) 5qpz(A) 5qq0(A) 5qq1(A) 5qq2(A) 5qq3(A) 5qq4(A) 5qq5(A) 5qq6(A) 5qq7(A) 5qq8(A) 5qq9(A) 5qqa(A) 5qqb(A) 5qqc(A) 6r04(A) 6r05(A) 6r06(A) 6r07(A) 6r08(A) 6r09(A) 6r0a(A) 6r0b(A) 6shv(A) 6si5(A)	Asp104 Asp252 Asp253 Lys209 His95 Phe248 Lys50 Asp100 Arg109 Asp172
1fps(A)	5qt4(A) 5qt5(A) 5qt6(A) 5qt7(A) 5qt8(A) 5qt9(A) 5qta(A) 5qtb(A) 5qtc(A) 5qtd(A) 5qte(A) 5qtf(A) 5qtg(A) 5qth(A) 5qti(A) 5qtj(A) 5qtk(A) 6r36(A) 6r37(A) 6r38(A) 6r39(A) 6sii(A)	Asp109 Asp257 Asp258 Lys214 His100 Phe253 Lys49 Asp105 Arg114 Asp177
1fps(A)	6sdn(A) 6sdo(A) 6sdp(A) 6sdq(A) 6se2(A) 6sf8(A) 6sf9(A) 6sfa(A) 6t7n(AAAA)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	6vjc(B,A)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	6w7i(B,A)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	6ww1(B,A)	Asp102 Asp250 Asp251 Lys207 His93 Phe246 Lys48 Asp98 Arg107 Asp170
1fps(A)	7buu(B,A) 7buv(C,E,G,F,D,A,B)	Asp119 Asp254 Asp255 Lys212 Cys110 Phe250 Lys63 Asp115 Arg124 Asp186
1fps(A)	7buw(B,A)	Asp117 Asp252 Asp253 Lys210 Tyr108 Phe248 Lys63 Asp113 Arg122 Asp184
1fps(A)	7bux(B,A)	Asp113 Asp248 Asp249 Lys206 Tyr104 Phe244 Lys63 Asp109 Arg118 Asp180