M-CSA Mechanism and Catalytic Site Atlas

Squalene-hopene cyclase (M-CSA:254)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1h3b

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1gsz(A, B, C), 1h35(A, B, C), 1h36(A, B, C), 1h37(A, B, C), 1h39(A, B, C), 1h3a(A, B, C), 1h3c(A, B, C), 1o6h(A, B, C), 1o6q(A, B, C), 1o6r(A, B, C), 1o79(A, B, C), 1sqc(A), 1ump(A, B, C)

PDB sequences homologous to 1h3b

Reference PDB chains/ identical chains	Homologous PDB chains	Asp374A Phe365A Asp376A His451A Trp489A Tyr495A Phe601A Phe605A Tyr609A Trp169A Glu45A Tyr420A Glu93A Arg127A Gln262A Trp312A Asp377A
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	2sqc(B,A)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6k(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	3sqc(B,A,C)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6j(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	Asp374 Phe365 Asp376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	2sqc(B,A)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6k(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	3sqc(B,A,C)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6j(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	Asp374 Phe365 Asp376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	2sqc(B,A)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6k(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	3sqc(B,A,C)	Asp374 Phe365 Cys376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1w6j(A)	Asp455 Phe444 Thr457 Ala536 Trp581 Tyr587 Phe696 Cys700 Tyr704 His232 Gly107 Tyr503 Leu156 Pro190 Ser339 Trp387 Ala458
1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	1h3b(B,A,C) 1ump(B,A,C) 1sqc(A) 1o6q(B,A,C) 1h36(B,A,C) 1o79(B,A,C) 1h3a(B,A,C) 1h39(B,A,C) 1o6h(B,A,C) 1h35(B,A,C) 1o6r(B,A,C) 1h3c(B,A,C) 1h37(B,A,C) 1gsz(B,A,C)	Asp374 Phe365 Asp376 His451 Trp489 Tyr495 Phe601 Phe605 Tyr609 Trp169 Glu45 Tyr420 Glu93 Arg127 Gln262 Trp312 Asp377