M-CSA Mechanism and Catalytic Site Atlas

Succinate dehydrogenase (ubiquinone) (M-CSA:294)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1yq4

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1yq3(A, B, C, D), 2fbw(A, B, D, N, O, Q), 2h88(A, B, D, N, O, Q), 2h89(A, B, D), 2wqy(A, B, D, N, O, Q), 6myo(A, B, D), 6myp(A, B, D), 6myq(A, B, D), 6myr(A, B, D), 6mys(A, B, D), 6myt(A, B, D), 6myu(A, B, D)

PDB sequences homologous to 1yq4

Reference PDB chains/ identical chains	Homologous PDB chains	Gln251A His253A His364A Arg408A Leu263A Glu266A Arg297A Phe130A
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2wu5(I,A,E) 1nek(A) 2ws3(E,A,I) 2wdv(I,A,E) 2wp9(E,A,I) 2acz(A) 2wu2(I,A,E) 2wdq(I,A,E) 1nen(A) 2wdr(E,A,I) 6c12(B,A) 6wu6(E,A,I) 7jz2(E,A,I)	Gln240 His242 His354 Arg399 Leu252 Glu255 Arg286 Phe119
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	5glg(A) 5zyn(B)	Gln249 His251 His405 Arg447 Leu268 Glu271 Arg296 Leu116
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1lj1(B,A)	Phe363 His365 His504 Arg544 Met375 Glu378 Ala402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1q9i(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1qlb(A,D)	Gln255 His257 His369 Arg404 Leu267 Glu270 Arg301 Phe141
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1e7p(G,A,D,J) 2bs3(A,D) 2bs4(A,D)	Gln255 His257 His369 Arg404 Leu267 Glu270 Arg301 Phe141
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1kfy(M,A) 1l0v(M,A) 1kf6(M,A) 6awf(E,A)	Gln231 His233 His356 Arg391 Leu243 Glu246 Arg288 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1zp0(A) 3ae9(A) 3aeg(A) 3sfd(A) 3ae3(A) 3aeb(A) 3aef(A) 3ae1(A) 3ae2(A) 3aed(A) 3abv(A) 3ae5(A) 3ae7(A) 3ae4(A) 1zoy(A) 3aee(A) 3ae6(A) 3sfe(A) 3ae8(A) 3aec(A) 3aea(A)	Gln252 His254 His365 Arg409 Leu264 Glu267 Arg298 Phe131
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1qjd(A) 1y0p(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1p2e(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2b7s(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	3cir(M,A)	Gln231 His233 His356 Arg391 Leu243 Glu246 Arg288 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1knr(A) 1knp(A)	Gln242 His244 His351 Leu386 Leu257 Glu260 Arg290 Glu121
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1d4c(C,B,A,D)	Gln363 His365 His504 Arg545 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1chu(A)	Gln242 His244 His351 Arg386 Leu257 Glu260 Arg290 Glu121
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1jrz(B,A)	Gln363 His365 His504 Arg544 Met375 Glu378 Tyr402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	5kxj(A)	Gln242 His244 His351 Arg386 Leu257 Glu260 Arg290 Glu121
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2b76(M,A)	Gln231 His233 His356 Arg391 Leu243 Glu246 Arg288 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2b7r(A)	Gln363 His365 His504 Arg544 Met375 Asp378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	4yxd(A) 4ytp(A)	Gln294 His296 His407 Arg451 Leu306 Glu309 Arg340 Phe173
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2bs2(A,D)	Gln255 His257 His369 Arg404 Leu267 Glu270 Arg301 Phe141
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	5c3j(E,A) 4ytn(E,A) 4ysy(E,A) 4yt0(E,A) 4ysx(E,A) 5c2t(E,A) 4ytm(E,A) 4ysz(E,A)	Gln274 His276 His387 Arg432 Leu286 Glu289 Arg320 Phe153
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	3vr9(E,A) 3vra(E,A) 3vrb(E,A) 3vr8(E,A)	Gln274 His276 His387 Arg432 Leu286 Glu289 Arg320 Phe153
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1jrx(B,A)	Gln363 His365 His504 Arg544 Met375 Glu378 Ala402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1jry(B,A)	Gln363 His365 His504 Arg544 Met375 Glu378 Lys402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1m64(B,A)	Phe363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	Gln251 His253 His364 Arg408 Leu263 Glu266 Arg297 Phe130
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	5vpn(E,A)	Gln231 His233 His356 Arg391 Leu243 Gln246 Arg288 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1kss(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	3p4r(M,A) 3p4s(M,A) 3p4p(M,A) 4kx6(M,A) 3p4q(M,A) 6b58(C,A)	Gln231 His233 His356 Arg391 Leu243 Glu246 Arg288 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1ksu(B,A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	2e5v(B,A)	Gln210 His212 His313 Arg348 Leu224 Glu227 Arg257 Glu102
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1qo8(A,D)	Gln358 His360 His499 Arg539 Leu370 Glu373 Arg397 Ser231
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1e39(A)	Gln363 Ala365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1d4d(A) 1d4e(A)	Gln363 His365 His504 Arg545 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	1p2h(A)	Gln363 His365 His504 Arg544 Met375 Glu378 Arg402 Met236
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	5xmj(E,M,A,I)	Gln255 His257 His369 Arg405 Leu267 Glu270 Arg301 Phe141
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	6n56(A)	Gln263 His265 His404 Arg439 Leu275 Glu278 Arg309 Phe149
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	6ku6(B,H)	Gln249 His251 His405 Arg447 Leu268 Glu271 Ala296 Leu116
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	6lum(P,A,J)	Gln241 His243 His354 Arg395 Leu253 Glu256 Arg287 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	6t85(A) 6t86(A) 6t87(A) 6t88(A)	Gln243 Tyr245 His392 Arg432 Ala256 Ala259 Arg283 Phe117
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	6vax(C,A)	Gln262 His264 His375 Arg419 Leu274 Glu277 Arg308 Phe141
1yq4(A) 2h88(N,A) 2h89(A) 1yq3(A) 2wqy(N,A) 2fbw(N,A) 6myo(A) 6myp(A) 6myq(A) 6myr(A) 6mys(A) 6myt(A) 6myu(A)	7d6v(A) 7d6x(A)	Gln247 His249 His388 Arg423 Leu263 Glu266 Arg322 Phe121