M-CSA Mechanism and Catalytic Site Atlas

E1 ubiquitin-activating enzyme (M-CSA:307)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P22515

Reference Sequence	Homologue	Asn781 (main-N) Asp782 (main-N) Arg481 Thr601 Arg603 Asp544 Cys600 Arg21
P22515	P22515	Asn781 Asp782 Arg481 Thr601 Arg603 Asp544 Cys600 Arg21
P22515	P20973	His809 Glu810 Arg509 Thr627 His629 Asp570 Cys626 Arg50
P22515	Q5U300	Ser810 Asp811 Arg515 Thr633 Lys635 Asp576 Cys632 Arg57
P22515	Q9UBE0	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg21
P22515	Q9R1T2	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg25
P22515	Q7SXG4	not aligned His329 not aligned Thr175 Arg177 not aligned Cys174 not aligned
P22515	A3KMV5	Ser810 Asp811 Arg515 Thr633 Lys635 Asp576 Cys632 Arg57
P22515	Q6IQS6	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg22
P22515	Q5NVN7	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg21
P22515	Q9ZV69	not aligned not aligned not aligned Lys373 Ala375 Lys350 Cys372 Arg10
P22515	Q9UBT2	not aligned Lys324 not aligned Thr174 Arg176 not aligned Cys173 not aligned
P22515	Q9SJT1	not aligned Glu318 not aligned Thr169 Thr171 not aligned Cys168 not aligned
P22515	Q18217	not aligned not aligned not aligned Lys379 Ala381 Arg357 Cys378 Arg12
P22515	O94609	Asn770 Glu771 Arg474 Thr594 Lys596 Asp537 Cys593 Arg22
P22515	Q06624	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg18
P22515	Q99MI7	not aligned Asp266 not aligned Thr238 Ala240 not aligned Cys237 Arg37
P22515	O65041	not aligned not aligned not aligned Thr216 Ala218 not aligned Cys215 Lys14
P22515	P92974	Asp835 Glu836 Arg536 Thr654 His656 Asp597 Cys653 Arg77
P22515	P79064	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg16
P22515	Q8TBC4	not aligned Glu266 not aligned Thr238 Ala240 not aligned Cys237 Arg37
P22515	Q5R4A0	not aligned Glu266 not aligned Thr238 Ala240 not aligned Cys237 Arg37
P22515	Q54QG9	not aligned not aligned not aligned Thr219 Ala221 not aligned Cys218 Arg13
P22515	P52488	not aligned Asn312 not aligned Thr178 Arg180 not aligned Cys177 not aligned
P22515	Q5ZIE6	not aligned not aligned not aligned Ser386 Ser388 Ala363 Cys385 Arg16
P22515	P31254	Ser809 Glu810 Arg514 Thr632 Lys634 Asp575 Cys631 Arg56
P22515	O42939	not aligned Asp318 not aligned Thr182 Arg184 not aligned Cys181 not aligned
P22515	Q8VY78	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg16
P22515	Q9V6U8	not aligned not aligned not aligned Thr218 Ala220 not aligned Cys217 Arg16
P22515	P0DI12	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg16
P22515	A2VE14	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg21
P22515	P31252	Asp811 Glu812 Arg512 Thr630 His632 Asp573 Cys629 Arg53
P22515	Q19360	not aligned not aligned not aligned Thr212 Ala214 not aligned Cys211 Arg11
P22515	Q9NAN1	not aligned Thr315 not aligned Thr171 Arg173 not aligned Cys170 not aligned
P22515	Q55C16	Ser768 Glu769 Arg475 Thr593 His595 Asp536 Cys592 Arg20
P22515	Q54L40	not aligned Asp321 not aligned Thr179 Arg181 not aligned Cys178 not aligned
P22515	Q28GH3	not aligned Lys322 not aligned Thr174 Arg176 not aligned Cys173 not aligned
P22515	Q6AXQ0	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg24
P22515	P22314	Ser810 Asp811 Arg515 Thr633 Lys635 Asp576 Cys632 Arg57
P22515	P93028	Asp838 Glu839 Arg539 Thr657 His659 Asp600 Cys656 Arg80
P22515	P41226	Ser771 Asn772 Arg479 Thr600 Arg602 Asp540 Cys599 Arg17
P22515	Q7ZVX6	not aligned Asp265 not aligned Thr237 Ala239 not aligned Cys236 Arg36
P22515	Q9Z1F9	not aligned Lys322 not aligned Thr174 Arg176 not aligned Cys173 not aligned
P22515	Q99344	not aligned not aligned not aligned Thr169 Ala171 not aligned Cys168 not aligned
P22515	Q8C878	not aligned Asp266 not aligned Thr238 Ala240 not aligned Cys237 Arg37
P22515	P30138	not aligned not aligned not aligned Gly244 Ser246 Arg235 Cys243 Arg11
P22515	Q09765	not aligned Asp248 not aligned Thr206 Ala208 not aligned Cys205 Arg13
P22515	P31251	Asp809 Glu810 Arg509 Thr627 His629 Asp570 Cys626 Arg50
P22515	Q54WI4	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg29
P22515	Q02053	Ser810 Asp811 Arg515 Thr633 Lys635 Asp576 Cys632 Arg57
P22515	A0AVT1	Asp805 Glu806 Arg508 Thr626 Lys628 Asp569 Cys625 Arg46
P22515	Q8C7R4	Asp805 Glu806 Arg508 Thr626 Lys628 Asp569 Cys625 Arg46
P22515	P42744	not aligned not aligned not aligned Lys390 Ala392 Lys367 Cys389 Arg26
P22515	Q29504	Ser810 Asp811 Arg515 Thr633 Lys635 Asp576 Cys632 Arg57
P22515	Q28DS0	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg19
P22515	Q17820	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg13
P22515	Q13564	not aligned not aligned not aligned Ser385 Ser387 Ala362 Cys384 Arg15
P22515	O59954	not aligned Asn362 not aligned Ser319 Glu321 Arg309 Cys318 Arg71
P22515	Q9Z1A5	not aligned not aligned not aligned Ser385 Ser387 Ala362 Cys384 Arg15
P22515	Q54JM3	not aligned not aligned not aligned Lys373 Thr375 Asp352 Cys372 Arg13
P22515	B4N7R4	not aligned Asp355 not aligned Ser313 Gln315 Arg303 Cys312 Arg75
P22515	Q2TWN3	not aligned Thr330 not aligned Ser287 Glu289 Arg277 Cys286 His41
P22515	Q7SXP2	not aligned not aligned not aligned Lys384 Ala386 Glu361 Cys383 Arg14
P22515	A1CAZ7	not aligned Lys364 not aligned Ser321 Glu323 Arg311 Cys320 Arg72
P22515	D4GSF3	not aligned not aligned not aligned Gly249 Glu250 Arg240 Cys248 Arg15
P22515	Q8VBW6	not aligned not aligned not aligned Ser385 Ser387 Ala362 Cys384 Arg15
P22515	Q8JGT5	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg19
P22515	P52495	Thr775 Asp776 Arg479 Thr599 Arg601 Asp542 Cys598 Arg22
P22515	A2R3H4	not aligned Thr356 not aligned Ser313 Glu315 Arg303 Cys312 Arg66
P22515	P31255	not aligned not aligned not aligned Thr52 Lys54 not aligned Cys51 not aligned
P22515	Q642Q1	not aligned Lys322 not aligned Thr174 Arg176 not aligned Cys173 not aligned
P22515	Q7ZY60	not aligned Lys322 not aligned Thr174 Arg176 not aligned Cys173 not aligned
P22515	P0DI13	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg16