M-CSA Mechanism and Catalytic Site Atlas

E1 ubiquitin-activating enzyme (M-CSA:307)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 3cmm

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1otr(B), 1q0w(B), 1wr1(A), 2g3q(B), 2jt4(B), 2l00(B), 5l6h(B, D, E), 5l6i(B, D, E), 5l6j(B, D), 5tr4(B, D), 5u4p(C), 6oa9(H, J, K), 6oaa(H), 6zqh(B, D)

PDB sequences homologous to 3cmm

Reference PDB chains/ identical chains	Homologous PDB chains	Asn781(772)A (main-N) Asp782(773)A (main-N) Arg481(472)A Thr601(592)A Arg603(594)A Asp544(535)A Cys600(591)A Arg21(12)A
3cmm(A,C)	3kyd(B)	not aligned not aligned not aligned Thr176 Arg178 Asp119 Cys175 Leu2
3cmm(A,C)	5um6(A)	Asn758 Glu759 Arg462 Thr582 Lys584 Asp525 Ala581 Arg10
3cmm(A,C)	3cmm(A,C)	Asn772 Asp773 Arg472 Thr592 Arg594 Asp535 Cys591 Arg12
3cmm(A,C)	1z7l(B,A,C)	Ser195 Asp196 not aligned Thr18 Lys20 not aligned Cys17 not aligned
3cmm(A,C)	3dbr(E,A,G,C) 3dbl(E,A,G,C) 1tt5(A,C) 3dbh(E,A,G,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg17
3cmm(A,C)	1r4n(E,A,G,C) 1r4m(E,A,G,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg15
3cmm(A,C)	1zud(1,3)	not aligned not aligned not aligned not aligned not aligned Asp127 not aligned Arg11
3cmm(A,C)	2nvu(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg17
3cmm(A,C)	1jw9(B) 1jwa(B) 1jwb(B)	not aligned not aligned not aligned not aligned not aligned Asp130 not aligned Arg14
3cmm(A,C)	1zkm(B,A,D,C) 1zfn(C,B,A,D)	not aligned not aligned not aligned not aligned not aligned Asp129 not aligned Arg13
3cmm(A,C)	3dbh(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	5tr4(A,C)	Asn774 Asp775 Arg474 Thr594 Arg596 Asp537 Cys593 Arg14
3cmm(A,C)	2v31(A) 2lzj(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned not aligned
3cmm(A,C)	3dbl(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	1yov(A,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg18
3cmm(A,C)	4nnj(A,C)	Asn797 Asp798 Arg497 Thr617 Arg619 Asp560 Cys616 Arg37
3cmm(A,C)	5l6i(A,C) 5l6j(A,C) 5l6h(A,C) 6zqh(A,C)	Asn781 Asp782 Arg481 Thr601 Arg603 Asp544 Cys600 Arg21
3cmm(A,C)	5knl(A,D) 4ii3(A,C) 4ii2(A) 6o82(A,C) 6o83(A,C)	Asn759 Glu760 Arg463 Thr583 Lys585 Asp526 Cys582 Arg11
3cmm(A,C)	3kyc(A) 1y8r(D,A) 1y8q(A,C) 3kyd(A) 6cwy(C) 6cwz(C) 6xog(A) 6xoh(A) 6xoi(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg21
3cmm(A,C)	3gzn(A,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg15
3cmm(A,C)	1yov(B,D)	not aligned not aligned not aligned Thr219 Ala221 Asp148 Cys218 Lys23
3cmm(A,C)	1y8q(B,D) 1y8r(E,B)	not aligned not aligned not aligned Thr174 Arg176 Asp117 Ala173 not aligned
3cmm(A,C)	2nvu(B)	not aligned not aligned not aligned Thr580 Ala582 Asp509 Cys579 Lys384
3cmm(A,C)	1r4n(F,B,D,H) 1r4m(F,B,D,H)	not aligned not aligned not aligned Thr206 Ala208 Asp135 Ala205 Lys10
3cmm(A,C)	3gzn(B,D)	not aligned not aligned not aligned Thr238 Ala240 Asp167 Cys237 Lys42
3cmm(A,C)	3dbr(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	3kyc(B)	not aligned not aligned not aligned Thr194 Arg196 Asp137 Cys193 His20
3cmm(A,C)	4p22(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg64
3cmm(A,C)	1tt5(B,D)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Cys208 Lys13
3cmm(A,C)	6cwy(D) 6cwz(D)	not aligned not aligned not aligned Thr194 Arg196 Asp137 Cys193 His20
3cmm(A,C)	6dc6(A,C)	Ser767 Asp768 Arg472 Thr590 Lys592 Asp533 Ala589 Arg14
3cmm(A,C)	6nya(A,D) 7k5j(U,I,K,G,S,D,A,C)	Asn774 Asp775 Arg474 Thr594 Arg596 Asp537 Cys593 Arg14
3cmm(A,C)	6xog(B) 6xoh(B) 6xoi(B)	not aligned not aligned not aligned Thr174 Arg176 Asp117 Cys173 not aligned
3cmm(A,C)	3kyd(B)	not aligned not aligned not aligned Thr176 Arg178 Asp119 Cys175 Leu2
3cmm(A,C)	5um6(A)	Asn758 Glu759 Arg462 Thr582 Lys584 Asp525 Ala581 Arg10
3cmm(A,C)	3cmm(A,C)	Asn772 Asp773 Arg472 Thr592 Arg594 Asp535 Cys591 Arg12
3cmm(A,C)	1z7l(B,A,C)	Ser195 Asp196 not aligned Thr18 Lys20 not aligned Cys17 not aligned
3cmm(A,C)	3dbr(E,A,G,C) 3dbl(E,A,G,C) 1tt5(A,C) 3dbh(E,A,G,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg17
3cmm(A,C)	1r4n(E,A,G,C) 1r4m(E,A,G,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg15
3cmm(A,C)	1zud(1,3)	not aligned not aligned not aligned not aligned not aligned Asp127 not aligned Arg11
3cmm(A,C)	2nvu(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg17
3cmm(A,C)	1jw9(B) 1jwa(B) 1jwb(B)	not aligned not aligned not aligned not aligned not aligned Asp130 not aligned Arg14
3cmm(A,C)	1zkm(B,A,D,C) 1zfn(C,B,A,D)	not aligned not aligned not aligned not aligned not aligned Asp129 not aligned Arg13
3cmm(A,C)	3dbh(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	5tr4(A,C)	Asn774 Asp775 Arg474 Thr594 Arg596 Asp537 Cys593 Arg14
3cmm(A,C)	2v31(A) 2lzj(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned not aligned
3cmm(A,C)	3dbl(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	1yov(A,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg18
3cmm(A,C)	4nnj(A,C)	Asn797 Asp798 Arg497 Thr617 Arg619 Asp560 Cys616 Arg37
3cmm(A,C)	5l6i(A,C) 5l6j(A,C) 5l6h(A,C) 6zqh(A,C)	Asn781 Asp782 Arg481 Thr601 Arg603 Asp544 Cys600 Arg21
3cmm(A,C)	5knl(A,D) 4ii3(A,C) 4ii2(A) 6o82(A,C) 6o83(A,C)	Asn759 Glu760 Arg463 Thr583 Lys585 Asp526 Cys582 Arg11
3cmm(A,C)	3kyc(A) 1y8r(D,A) 1y8q(A,C) 3kyd(A) 6cwy(C) 6cwz(C) 6xog(A) 6xoh(A) 6xoi(A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg21
3cmm(A,C)	3gzn(A,C)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg15
3cmm(A,C)	1yov(B,D)	not aligned not aligned not aligned Thr219 Ala221 Asp148 Cys218 Lys23
3cmm(A,C)	1y8q(B,D) 1y8r(E,B)	not aligned not aligned not aligned Thr174 Arg176 Asp117 Ala173 not aligned
3cmm(A,C)	2nvu(B)	not aligned not aligned not aligned Thr580 Ala582 Asp509 Cys579 Lys384
3cmm(A,C)	1r4n(F,B,D,H) 1r4m(F,B,D,H)	not aligned not aligned not aligned Thr206 Ala208 Asp135 Ala205 Lys10
3cmm(A,C)	3gzn(B,D)	not aligned not aligned not aligned Thr238 Ala240 Asp167 Cys237 Lys42
3cmm(A,C)	3dbr(F,B,D,H)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Ala208 Lys13
3cmm(A,C)	3kyc(B)	not aligned not aligned not aligned Thr194 Arg196 Asp137 Cys193 His20
3cmm(A,C)	4p22(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned not aligned Arg64
3cmm(A,C)	1tt5(B,D)	not aligned not aligned not aligned Thr209 Ala211 Asp138 Cys208 Lys13
3cmm(A,C)	6cwy(D) 6cwz(D)	not aligned not aligned not aligned Thr194 Arg196 Asp137 Cys193 His20
3cmm(A,C)	6dc6(A,C)	Ser767 Asp768 Arg472 Thr590 Lys592 Asp533 Ala589 Arg14
3cmm(A,C)	6nya(A,D) 7k5j(U,I,K,G,S,D,A,C)	Asn774 Asp775 Arg474 Thr594 Arg596 Asp537 Cys593 Arg14
3cmm(A,C)	6xog(B) 6xoh(B) 6xoi(B)	not aligned not aligned not aligned Thr174 Arg176 Asp117 Cys173 not aligned