M-CSA Mechanism and Catalytic Site Atlas

NADPH dehydrogenase (M-CSA:319)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1oya

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1oyb(A), 1oyc(A), 3tx9(A)

PDB sequences homologous to 1oya

Reference PDB chains/ identical chains	Homologous PDB chains	Asn251(252)A His191(192)A Asn194(195)A Thr37(38)A Tyr196(197)A
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1gwj(A)	Phe246 His186 Asn189 Thr32 Cys191
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3k30(B,A)	Asp238 Tyr176 His179 Cys35 Tyr181
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3gka(B,A)	His241 His181 Asn184 Thr33 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5epd(A)	Asn256 His196 Asn199 Thr47 Tyr201
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4tmc(C,B,A,D) 4tmb(C,B,A,D)	Gly251 His191 Asn194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1gvq(A) 1vyr(A) 3f03(K) 1h60(A) 1h62(A) 1gvr(A) 2aba(A) 1h50(A) 1gvo(A) 3kft(B,A) 1h63(A) 1h51(A) 1h61(A) 1gvs(A)	Gln241 His181 His184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p84(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4awt(A) 4aws(A)	Asn241 His181 Asn184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3hgs(B,A) 2hsa(B,A) 2hs6(B,A)	Leu251 His191 His194 Thr39 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5dy2(A) 5dy3(A) 5dxy(A)	Thr240 His180 His183 Thr28 Tyr185
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5dxx(A)	Thr240 His180 His183 Thr28 Tyr185
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5cpo(B,A) 5cpn(B,A) 5cpm(B,A) 5cpl(B,A)	Arg240 His178 His181 Cys25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4gxm(A) 4gwe(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4ge8(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3wjs(A)	Gln232 His172 Asn175 Thr25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4ab4(B,A) 4aeo(B,A)	His233 His173 Asn176 Thr25 Tyr178
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3n14(A)	Arg240 His178 His181 Cys25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3hf3(C,B,A,D) 3hgj(C,B,A,D)	Glu233 His172 His175 Cys25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3txz(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3hgo(B,A)	Leu251 His191 His194 Thr39 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3l5a(A)	Asp258 Ser190 Gln193 Thr49 Leu195
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2gou(A) 2gq9(A) 2gq8(A) 2gqa(A)	Asn241 His181 Asn184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4rnv(C,B,A,D) 4rnu(C,B,A,D)	Asn350 His290 Asn293 Thr136 Tyr295
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3l67(A) 3l68(A)	Arg240 His178 His181 Ser25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4utm(A) 4uti(A) 4uth(A) 4utj(A) 4utk(A) 4utl(A)	Arg242 His180 His183 Cys27 Phe185
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1icq(B,A) 3hgr(B,A) 1icp(B,A) 1ics(B,A)	Asn247 His187 His190 Thr37 Tyr192
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3gr8(B,A) 3gr7(B,A)	Pro223 His164 His167 Cys26 Tyr169
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4e2d(C,B,A,D) 4e2b(A)	His260 His198 Asn201 Thr31 Tyr203
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4qai(E,C,F,D,A,B)	Gln248 His188 His191 Thr35 Tyr193
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1bwl(A)	Asn251 Asn191 His194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1o94(B,A) 1djn(B,A) 1o95(B,A) 2tmd(B,A)	Tyr229 Tyr169 His172 Cys30 Tyr174
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4rnx(B,A)	Asn100 His40 Asn43 not aligned Tyr45
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5n6g(A)	Asn238 His178 Asn181 Thr25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4m5p(A)	Gln248 His188 His191 Thr35 Tyr193
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3atz(C,B,A,D) 3aty(B,A)	His257 His195 Asn198 Thr28 Tyr200
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3l5m(A) 3l5l(A) 3n19(B,D)	Arg240 His178 His181 Cys25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2g5w(B,A) 2q3o(B,A) 1q45(B,A)	Leu246 His186 His189 Thr33 Tyr191
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1z42(B,A) 1z41(B,A) 1z48(B,A) 1z44(B,A)	Asp223 His164 His167 Cys26 Tyr169
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5ocs(C,B,A,D)	Pro239 His178 His181 Cys25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4ync(A) 4yil(A)	Asn251 His191 Asn194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1k02(A) 1k03(A)	Asn251 His191 Asn194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p62(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3l66(A) 3l65(A)	Arg240 His178 His181 Ala25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4ot7(A)	Ser255 His192 Asn195 Thr45 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p8i(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4rnw(B,A)	Asn346 His286 Asn289 Thr132 Tyr291
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2r14(A)	Phe246 His186 Asn189 Thr32 Cys191
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4qnw(A)	Leu233 His173 Asn176 Thr31 Tyr178
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2hs8(B,A)	Leu251 His191 His194 Thr39 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p7y(A) 3p80(A) 3p81(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5lnj(A)	Arg239 His177 His180 Cys24 Phe182
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2h90(A) 2h8z(A)	Arg239 His177 His180 Cys24 Tyr182
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4awu(A)	Asn241 His181 Asn184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4gbu(A) 4k7v(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p74(A)	Gln242 Asn182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5lni(A)	Arg239 His177 His180 Cys24 Phe182
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5v4p(B,A) 5v4v(B,A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4a3u(B,A)	Gln232 His172 Asn175 Thr25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1vji(A) 2q3r(A)	Met243 His183 Asn186 Thr33 Tyr188
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1djq(B,A)	Tyr229 Tyr169 His172 Ala30 Tyr174
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1bwk(A)	Asn251 Asn191 Asn194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4df2(A)	Gln248 His188 His191 Thr35 Tyr193
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p82(A)	Gln242 His182 Asn185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1vyp(X)	Gln241 His181 His184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p67(A)	Gln242 His182 His185 Ser27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3p8j(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2abb(A)	Gln241 His181 His184 Thr26 Phe186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5k1q(A) 5k1w(A) 5k1u(A) 4b5n(A) 5k1m(A) 5k0r(A) 5k1k(A)	Asn242 His182 Asn185 Thr35 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3krz(C,B,A,D)	Glu224 His163 His166 Cys25 Tyr168
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5lgx(A) 5lgz(A)	Gln240 His180 His183 Thr25 Tyr185
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3kru(C,B,A,D)	Glu224 His163 His166 Cys25 Tyr168
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3tjl(A) 3upw(A)	Gln248 His188 His191 Thr35 Tyr193
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4k7y(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1ps9(A)	Glu222 Met161 Glu164 His26 Tyr166
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	2h8x(A)	Arg238 His176 His179 Cys23 Tyr181
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4jic(C,B,A) 4jip(A) 4jiq(A)	Asn238 His178 Asn181 Thr25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5n6q(B,A)	Arg240 His178 His181 Cys25 Tyr183
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4k8h(A) 4k8e(A) 4h4i(A)	Asn252 His192 Asn195 Thr38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	3gx9(A)	Phe246 His186 Ala189 Thr32 Cys191
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	1vys(X)	Gln241 His181 His184 Thr26 Tyr186
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	4h6k(A) 3rnd(A)	Asn251 His191 Asn194 Thr37 Tyr196
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5nux(C,B,A,D)	Glu233 His172 His175 Asp25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	5ogt(C,B,A,D)	Glu233 His172 His175 Asp25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6agz(B,A)	Gln247 His187 His190 Thr35 Tyr192
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6de6(B,A)	Gly236 Tyr174 His177 Cys33 Phe179
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6gi7(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6gi8(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6gi9(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6gia(A)	Gln242 His182 His185 Thr27 Tyr187
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6myw(C,B,A,D)	Gln232 His172 Asn175 Thr25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6o08(A)	Gln232 His172 Asn175 Thr25 Tyr177
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6qkg(B,A) 6qkr(B,A) 6qkx(A)	Glu253 Cys192 Val195 Val38 Tyr197
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6s0g(B) 6s23(B,A)	Met254 His194 Asn197 Thr45 Tyr199
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6s31(A)	Met254 His194 Asn197 Thr45 Tyr199
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6s32(C,B,A,D)	Gly258 His198 Asn201 Thr48 Tyr203
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	6uff(C,E,G,F,D,A,H,B)	Asn274 His214 Asn217 Thr65 Tyr219
1oya(A) 1oyc(A) 3tx9(A) 1oyb(A)	7o0t(C,B,A,D)	Pro238 His177 His180 Cys26 Tyr182