M-CSA Mechanism and Catalytic Site Atlas

Histidine ammonia-lyase (M-CSA:417)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1b8f

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1gkm(A)

PDB sequences homologous to 1b8f

Reference PDB chains/ identical chains	Homologous PDB chains	Phe329(327)A Asn195(193)A Glu414(412)A Tyr53A His83A Tyr280(278)A(AA) Arg283(281)A(AA)
1b8f(A) 1gkm(A)	1eb4(A)	Gly327 Leu193 Asn412 Tyr53 His83 Asp278 Ser281
1b8f(A) 1gkm(A)	1t6p(C,E,G,F,D,A,H,B) 1y2m(C,B,A,D) 1t6j(B,A)	Gly411 Leu268 Ala498 Tyr110 Gln138 Asp361 Pro364
1b8f(A) 1gkm(A)	3kdy(B,A)	Ala354 Leu203 Asp440 Tyr63 His93 Lys306 Ser309
1b8f(A) 1gkm(A)	3kdz(B,A)	Ala354 Leu203 Asp440 Phe63 His93 Lys306 Ser309
1b8f(A) 1gkm(A)	2nyn(C,B,A,D)	Gly361 Met221 Phe450 Tyr78 Leu108 Asp312 Ser315
1b8f(A) 1gkm(A)	3nz4(B,A)	Ala369 Leu229 His457 Tyr80 Leu108 Asp320 Ala323
1b8f(A) 1gkm(A)	1gk2(C,B,A,D)	Gly327 Leu193 Asn412 Tyr53 His83 Asp278 Ser281
1b8f(A) 1gkm(A)	2qve(B,A)	Ala343 Leu192 Asp429 Tyr52 His82 Lys295 Ser298
1b8f(A) 1gkm(A)	2ohy(B,A)	Ala356 Leu205 Asp442 Tyr65 His95 Lys308 Ser311
1b8f(A) 1gkm(A)	5ltm(B,A)	Gly337 Met197 Phe426 Phe54 Leu84 Asp288 Ser291
1b8f(A) 1gkm(A)	3unv(B,A)	Gly365 Leu216 Asp452 Tyr78 Val108 Asp316 Ser319
1b8f(A) 1gkm(A)	1gk3(A)	Gly327 Leu193 Asn412 Tyr53 His83 Asp278 Ser281
1b8f(A) 1gkm(A)	1w27(B,A)	Gly398 Leu258 His486 Tyr110 Leu138 Asp349 Ala352
1b8f(A) 1gkm(A)	6at7(B,A)	x x x x x x x
1b8f(A) 1gkm(A)	4v2q(B,A)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	4c5s(C,B,A,D) 4cq5(C,B,A,D)	Ala389 Leu249 His477 Ala100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	4baa(C,B,A,D)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	2o78(C,E,G,F,D,A,H,B) 2o7e(E,C,G,F,D,A,H,B) 2o7f(C,E,G,F,D,A,H,B)	Gly348 Leu201 Ala434 Tyr60 Leu90 Asp298 Ser301
1b8f(A) 1gkm(A)	4c6g(C,B,A,D)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	2rjr(B,A) 2rjs(B,A)	Ala354 Leu203 Asp440 Tyr63 His93 Lys306 Ser309
1b8f(A) 1gkm(A)	3czo(C,B,A,D)	Gly337 Met197 Phe426 Tyr54 Leu84 Asp288 Ser291
1b8f(A) 1gkm(A)	4c5r(C,B,A,D) 2yii(C,B,A,D) 4bab(C,B,A,D)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	2o7d(C,E,G,F,D,A,H,B) 2o7b(E,C,G,F,D,A,H,B) 2o6y(E,C,G,F,D,A,H,B)	Gly348 Leu201 Ala434 Tyr60 Leu90 Asp298 Ser301
1b8f(A) 1gkm(A)	4v2r(B,A)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	1b8f(A) 1gkm(A)	Phe327 Asn193 Glu412 Tyr53 His83 Tyr278 Arg281
1b8f(A) 1gkm(A)	4c5u(C,B,A,D)	Ala389 Leu249 His477 Tyr100 Leu128 Asp340 Ala343
1b8f(A) 1gkm(A)	1gkj(A)	Gly327 Leu193 Asn412 Tyr53 His83 Asp278 Ser281
1b8f(A) 1gkm(A)	2nyf(A)	Gly361 Met221 Phe450 Tyr78 Leu108 Asp312 Ser315
1b8f(A) 1gkm(A)	6f6t(B,A) 6h2o(B,A) 6hqf(B,A)	x x x x x x x
1b8f(A) 1gkm(A)	6rgs(B,A)	x x x x x x x
1b8f(A) 1gkm(A)	6s7j(C,E,G,F,D,A,H,B) 6s7q(C,E,G,F,D,A,H,B)	x x x x x x x
1b8f(A) 1gkm(A)	6v6h(C,B,A,D)	x x x x x x x